ThermoTargetMiner as a proteome integral solubility alteration target database for prospective drugs against lung cancer
Hezheng Lyu,
Hassan Gharibi,
Bohdana Sokolova
et al.
Abstract:Knowledge of the targets of therapeutic compounds is vital for understanding their action mechanisms and side effects, but such valuable data is seldom available. The multiple complementary techniques needed for comprehensive target characterization must combine data reliability with sufficient analysis throughput. Here, we leveraged the Proteome Integral Solubility Alteration (PISA) assay to comprehensively characterize the targets of 67 approved drugs and candidate compounds against lung cancer. The analysis… Show more
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