Thermosensitive ZrP-PNIPAM Pickering Emulsifier and the Controlled-Release Behavior

Wang, Xuezhen; Zeng, Minxiang; Yu, Yi‐Hsien; Wang, Shuangfeng; Mannan, M. Sam; Cheng, Zhengdong

doi:10.1021/acsami.6b16690

Cited by 53 publications

(35 citation statements)

References 33 publications

(67 reference statements)

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“…There have been numerous examples of nanocarriers composed of thermoresponsive polymers that can be applied for releasing active substances using either temperature-triggered or other types of mechanisms [23][24][25][26][27]. One may observe also a growing interest concerning mechanized silica nanoparticles that utilize supramolecular nanovalves responding to external stimuli for controlled release of encapsulated substances [28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Polymer Gating System on Mesoporous Shells of Silica Particles Serving as Smart Nanocontainers

2020

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Spherical silica nanoparticles with solid cores and mesoporous shells (SCMS) were decorated with thermoresponsive polymer brushes that were shown to serve as macromolecular valves to control loading and unloading of a model dye within the mesopores. Thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) brushes were grafted from the surfaces of both solid core (SC) and SCMS particles of similar size using surface-initiated atom transfer radical polymerization. Both systems based on porous (SCMS-PNIPAM) and nonporous (SC-PNIPAM) particles were characterized using cryo-TEM, thermogravimetry and elemental analysis to determine the structure and composition of the decorated nanoparticles. The grafted PNIPAM brushes were found to be responsive to temperature changes enabling temperature-controlled gating of the pores. The processes of loading and unloading in the obtained systems were examined using a model fluorescent dye—rhodamine 6G. Polymer brushes in SCMS-PNIPAM systems were shown to serve as molecular valves enabling significant adsorption (loading) of the dye inside the pores with respect to the SC-PNIPAM (no pores) and SCMS (no valves) systems. The effective unloading of the fluorescent cargo molecules from the decorated nanoparticles was achieved in a water/methanol solution. The obtained SCMS-PNIPAM particles may be used as smart nanocontainers or nanoreactors offering also facile isolation from the suspension due to the presence of dense cores.

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Section: Introductionmentioning

confidence: 99%

Thermoresponsive Polymer Gating System on Mesoporous Shells of Silica Particles Serving as Smart Nanocontainers

2020

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“…[9] Recently,a na symmetrically modified two-dimensional (2D) nanoparticle system was developed by exfoliation of layered zirconium phosphate,e nabling at emperature-triggered release of liquid crystals. [10] Along with the one-way release,the imitation of the dynamic gating function of biological ion channels appears to be highly valuable, particularly for long-term applications such as controlled release of corrosion inhibitors in oil pipelines. [11] To achieve such switchable releasing feature,a ni deal NP surfactant should form ar obust multilayer film at the interfaces to prevent the escape of encapsulated substances,while becoming repulsive upon introducing the stimuli in aq uick and possibly adjustable manner.…”

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confidence: 99%

Electrostatic‐Driven Dynamic Jamming of 2D Nanoparticles at Interfaces for Controlled Molecular Diffusion

et al. 2018

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Dynamically engineering the interfacial interaction of nanoparticles has emerged as anew approach for bottom-up fabrication of smart systems to tailor molecular diffusion and controlled release.J anus zwitterionic nanoplates are reported that can be switched between al ocked and unlocked state at interfaces upon changing surface charge,a llowing manipulation of interfacial properties in af ast, flexible,a nd switchable manner.C ombining experimental and modeling studies,a n unambiguous correlation is established among the electrostatic energy,t he interface geometry,a nd the interfacial jamming states.A saproof-of-concept, the well-controlled interfacial jamming of nanoplates enabled the switchable molecular diffusion through liquid-liquid interfaces,c onfirming the feasibility of using nanoparticle-based surfactants for advanced controlled release.

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“…When utilised in Pickering emulsions, this change in geometry can cause destabilisation or increased permeability, causing cargo release. [84] Poly(N-isopropylacrylamide), pNIPAM, is one of the most extensively used thermoresponsive polymers for biomedical applications as its conformational transition temperature is close to biological temperatures (32 °C) and it can be easily modified. Within Pickering emulsion research, pNIPAM can be used independently as the emulsifier [85] or grafted onto other materials to achieve a responsive stabilising agent.…”

Section: Thermoresponsive Pickering Emulsionsmentioning

confidence: 99%

“…Within Pickering emulsion research, pNIPAM can be used independently as the emulsifier [85] or grafted onto other materials to achieve a responsive stabilising agent. [22,84,[86][87][88] Below the polymer transition temperature, in its hydrophilic state, Pickering emulsions remain stable, however when raised above this temperature, their hydrophobic transformation alters particle wettability and disintegrates the emulsion. This approach holds advantages due to its reversibility and the narrow temperature range and timeframe of transition.…”

Section: Thermoresponsive Pickering Emulsionsmentioning

confidence: 99%

Recent developments in Pickering emulsions for biomedical applications

Harman

Patel

Guldin

et al. 2019

Current Opinion in Colloid & Interface Science

122

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Pickering emulsions, stabilised by organic or inorganic particles, offer long-term dispersibility of liquid droplets and resistance to coalescence. The versatility of stabilising particles and their ability to encapsulate and release cargo with high internal payload capacity makes them attractive in a wide variety of applications, ranging from catalysis to the cosmetic and food industry. While these properties make them an equally promising material platform for pharmaceutical and clinical applications, the development of Pickering emulsions for healthcare is still in its infancy. Herein, we summarise and discuss recent progress in the development of Pickering emulsions for biomedical applications, probing their design for passive diffusion-based release as well as stimuli-responsive destabilisation. We further comment on challenges and future directions of this exciting and rapidly expanding area of research.Pickering emulsions have been applied in a number of areas of research and industrial importance, such as food manufacturing, cosmetics, agrochemicals and therapeutic delivery. Their popularity in biomedical applications (i.e. for use in healthcare, such as therapeutics, diagnostics or imaging), in particular, has increased dramatically in recent years, thanks to their high stability, capacity for superior cargo loading compared to conventional systems, and diverse range of stabilising particles, creating a broad library of available building blocks. For biomedical and pharmaceutical application, the choice of emulsifier is critical; it must be biocompatible, non-toxic, and be able to be excreted from the body (if necessary). In this article, we will review the latest developments in the design and application of Pickering emulsions for biomedicine, with a focus on stimuli-responsive Pickering emulsions as a route to the triggered release of a payload towards advanced therapeutic delivery strategies. Within this discussion, we will describe systems which have been applied in proof of concept and in vitro assessments and emphasise areas of potential future development.

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Thermosensitive ZrP-PNIPAM Pickering Emulsifier and the Controlled-Release Behavior

Cited by 53 publications

References 33 publications

Thermoresponsive Polymer Gating System on Mesoporous Shells of Silica Particles Serving as Smart Nanocontainers

Thermoresponsive Polymer Gating System on Mesoporous Shells of Silica Particles Serving as Smart Nanocontainers

Electrostatic‐Driven Dynamic Jamming of 2D Nanoparticles at Interfaces for Controlled Molecular Diffusion

Recent developments in Pickering emulsions for biomedical applications

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