Thermosensitive-polymer-coated magnetic nanoparticles: Adsorption and desorption of Bovine Serum Albumin

Shamim, Nabila; Hong, Liang; Hidajat, K.; Uddin, M.S.

doi:10.1016/j.jcis.2006.08.047

Cited by 120 publications

(65 citation statements)

References 32 publications

(33 reference statements)

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“…Also, electrostatic interactions can play an important role (Koutsoukos et al 1982;Liang et al 2008;Shamim et al 2006;Yoon et al 1999), and there is evidence that the size of the particle may be another factor influencing protein adsorption (Cedervall et al 2007a).…”

Section: Kinetics Of Protein Bindingmentioning

confidence: 99%

Toxico-/biokinetics of nanomaterials

et al. 2012

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Nanomaterials (NM) offer great technological advantages but their risks to human health are still under discussion. For toxicological testing and evaluation, information on the toxicokinetics of NM is essential as it is different from that of most other xenobiotics. This review provides an overview on the toxicokinetics of NM available to date. The toxicokinetics of NM depends on particle size and shape, protein binding, agglomeration, hydrophobicity, surface charge and protein binding. In most studies with topical skin application, unintentional permeation and systemic availability were not observed; permeation for some NM with distinct properties was observed in animals. Upon inhalation, low levels of primary model nanoparticles became systemically available, but many real-world engineered NM aggregate in aerosols, do not disintegrate in the lung, and do not become systemically available. NM are prone to lymphatic transport, and many NM are taken up by the mononuclear phagocyte system (MPS) acting as a depot. Their half-life in blood depends on their uptake by MPS rather than their elimination from the body. NM reaching the GI tract are excreted with the feces, but of some NM low levels are absorbed and become systemically available. Some quantum dots were not observably excreted in urine nor in feces. Some model quantum dots, however, were efficiently excreted by the kidneys below, but not above 5-6 nm hydrodynamic diameter, while nanotubes 20-30 nm thick and 500-2,000 nm long were abundant in urine. NM are typically not metabolized. Some NM cross the blood-brain barrier favored by a negative surface charge.

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Section: Kinetics Of Protein Bindingmentioning

confidence: 99%

Toxico-/biokinetics of nanomaterials

et al. 2012

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“…To measure the binding of SP-A onto the metal oxide nanoparticles, samples of both the supernatant and the pellet of the previously described adsorption experiment were each analyzed by SDS-PAGE under reducing conditions, protein adsorption has been reported to be pH-dependent, the maximum being near to the isoelectric point [26,27]. This, however, might be not transferable to the adsorption of SP-A onto BaSO 4 , as the pH of the BaSO 4 dispersion of 8.6 differs from the pI of SP-A of 4.4-5.6.…”

Section: Particle Propertiesmentioning

confidence: 99%

Interaction of metal oxide nanoparticles with lung surfactant protein A

Schulze

Schaefer

Ruge

et al. 2011

European Journal of Pharmaceutics and Biopharmaceutics

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“…It has been also speculated that hydrophobic surfaces can effectively adsorb proteins of the serum that may favor cell up-take. [120] These results show that thermally controlled "smart" nanocarriers can be easily designed by assembling gold nanoparticles and thermosensitive polymers. These systems can target those sites, namely solid tumors and inflamed tissues, where local temperatures can be higher compared to normal tissue.…”

Section: Thermosensitive Gold Nanoparticles For Tumor Targetingmentioning

confidence: 85%

Supramolecular Bioconjugates for Protein and Small Drug Delivery

Salmaso

Bersani

Scomparin

et al. 2010

Israel Journal of Chemistry

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Supramolecular conjugation techniques have been developed to produce novel nanosized systems by assembling materials with diverse physicochemical and biological features. These techniques have been adapted to obtain innovative bioconjugates to deliver drugs with poor biopharmaceutical properties and nano‐devices with potential “theranostic” activity. Supramolecular drug delivery systems include polymer therapeutics such as drug–polymer bioconjugates, and colloidal carriers such as micelles, liposomes, polyplexes, and organic and inorganic nanoparticles. By virtue of their wide array of chemical composition and properties, polymers represent key elements for the construction of novel supramoelcular formulations. Polymer bioconjugation is a fledged technique for fabrication of protein–polymer conjugates. PEGylation, in particular, produces derivatives with enhanced pharmacokinetic, immunological, and stability properties as compared to the parent protein. Over the years, new methods have been set up to obtain site‐directed polymer conjugation. In this review we report few grafting to and growing from PEGylation examples for the preparation of therapeutically effective protein bioconjugates. Supramolecular formulations with unique properties can be also obtained by assembling functional polymers, targeting agents, physicochemical modifiers, and biomodulators. These systems may be designed for disease tissue disposition and cell recognition/penetration. Cyclodextrins, for example, have been functionalized with polyethylene glycol and folic acid to produce tumor‐targeted drug carriers. Interesting results have been obtained with this novel class of drug delivery systems. In addition, responsive polymers have been conjugated to gold nanoparticles to endow a new colloidal platform with triggerable cell disposition properties, which can be exploited either in biomedicine or diagnosis.

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Thermosensitive-polymer-coated magnetic nanoparticles: Adsorption and desorption of Bovine Serum Albumin

Cited by 120 publications

References 32 publications

Toxico-/biokinetics of nanomaterials

Toxico-/biokinetics of nanomaterials

Interaction of metal oxide nanoparticles with lung surfactant protein A

Supramolecular Bioconjugates for Protein and Small Drug Delivery

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