Thermosensitive poly(N-isopropylacrylamide)-b-poly(ε-caprolactone) nanoparticles for efficient drug delivery system

Choi, Changyong; Chae, Su Young; Nah, Jae-Won

doi:10.1016/j.polymer.2006.05.011

Cited by 165 publications

(105 citation statements)

References 51 publications

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“…It is necessary to mention that the release rate of indomethacin in this work is lower than that reported by Park et al [13] and Choi et al [16] at 25°C. In the investigation of Park and Choi, drug was loaded into the beads by the sorption method, and most of the drug existed in the surface layer of the beads.…”

Section: Drug Release Studycontrasting

confidence: 64%

“…In the higher pH PBS, the carboxylic acid groups were ionized and became -COO -form. Thus, the weakened H-bonding interaction between polymer chains and electrostatic repulsion from -COO -groups resulted in the higher swelling ratio [16]. Additionally, no significant difference of the swelling ratios was observed among all the samples in pH = 7.4 PBS at 25°C.…”

Section: Swelling Studymentioning

confidence: 86%

“…The unique properties of a smart hydrogel imply that it can be used as a promising material in the biomedical and industrial applications. Some significant applications of hydrogels have been widely investigated including dialysis membranes [11], enzyme immobilization [12], tissue engineering [13], and drug controlled release systems [14][15][16][17] and so on. Among the smart materials, pH-and temperature-sensitive hydrogels have been paid more attentions because the two physiological factors are very important for the human body [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with core-shelled structure

Deng¹,

Zhong²,

Tian³

et al. 2010

Express Polym. Lett.

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Abstract. In this study, a novel pH/temperature sensitive hydrogel bead with core-shelled structure, composed of calcium alginate (Ca-alginate) and poly(N-acryloylglycine) (PAG), was prepared using as a drug delivery system. The equilibrium swelling has indicated the distinct sensitivities of the beads to pH value and temperature. In pH = 7.4 phosphate buffer solution (PBS), the cumulative release amount of indomethacin loaded in the core of the beads was about 83.5% within 650 min, whereas this value only reached 16.6% in pH = 2.1 PBS. In addition, the release rate of indomethacin was much faster at 37°C than that at 24°C. The experimental results have showed that the Ca-alginate/PAG beads have a potential application for the pH/temperature-controlled drug release carrier in the biomedical field.

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Section: Drug Release Studycontrasting

confidence: 64%

Section: Swelling Studymentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with core-shelled structure

Deng¹,

Zhong²,

Tian³

et al. 2010

Express Polym. Lett.

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show abstract

“…The self-assembled structures are composed of two basic compartments of hydrophobic core and hydrophilic corona, at which they have been used to solubilize poorly soluble drugs/compounds [8,9,10]. Owing to such supramolecular structure, the hydrophobic drugs can associate with the inner cores of polymers, while the hydrophilic shells of polymer interact with the external environment.…”

Section: Introductionmentioning

confidence: 99%

Novel thermosensitive poly (N-isopropylacrylamide-co-vinylpyrrolidone-co-methacrylic acid) nanosystems for delivery of natural products.

Mashinchian¹,

Salehi²,

Dehghan³

et al. 2010

Int J Drug delivery

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The purpose of this research was to synthesize polymer based smart nanosystems for delivery of important bioactive natural products such as sesquiterpene coumarin derivatives of ferula szowitsiana, farnesiferol C as a potent anticancer. To this aim, polymeric micelles were prepared using Nisopropylacrylamide (NIPAAM), vinyl pyrrolidone (VP) and methacrylate (MAA) as monomers which were cross-linked with N, N-methylene bisacrylamide (MBA). The molar ratio of the PNIPAAm: VP: MAA group was 75.7:9.5:14.8. These micelles were further characterized upon their physicochemical properties using particle size analyzer, FT-IR, H-/C-NMR, HPLC. Particle size analyzer resulted in ~500 nm micelles with ~95% drug entrapments. Drug release from the polymeric micelles after 300 hours at 37°C and 40°C were 60 and 98 %, respectively. Upon these findings, it is proposed that the P (N-isopropylacrylamide-co-Methacrylic acid-coVinylpyrrolidone) micelles may be considered as thermosensitive delivery nanosystem.

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“…4 Effect of surfactants (Twean 60 and Cremophor RH 40) and drug loading (nystatin) on the drug release rate from ethylene vinyl acetate copolymer was investigated. 5 Choi et al 6 synthesized thermosensitive poly(n-isopropylacrylamide)-b-poly(ε-caprolactone) nanoparticles by hydroxyl-terminated poly(Nisopropylacrylamide) initiated ring opening polymerization of ε-caprolactone. The polymer was found to be efficient for sustained drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Utilization of Acrylamide and Natural Polysaccharide Based Polymeric Networks in Ph Controlled Release of 5-Amino Salicylic Acid

Kumar

Kaith

Mittal

2010

J. Chil. Chem. Soc.

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In this paper, psyllium (Psy) and acrylamide (AAm) based superabsorbent, synthesized using potassium persulphate (KPS) as an initiator and hexamethylene tetramine (HTMA) as a crosslinker, has been investigated for its swelling behaviour in distilled water as a function of time, temperature and pH. The hydrogel has further been applied for controlled delivery of 5-amino salicylic acid (5-ASA) under different pH conditions at 37 ºC. It has been found to show Fickian type mechanism as the drug release showed diffusion coefficient less than 0.50 for all the pH conditions.The gel characteristic constant has been found to show 6.9 × 10 -2 , 20.61 × 10 -2 and 33.4 × 10 -2 values for pH 4.0, 7.0 and 9.2, respectively. The initial diffusion coefficient has been found to show greater values than late diffusion coefficient confirming greater release at the early stages of the drug release than that in the late stages.

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Thermosensitive poly(N-isopropylacrylamide)-b-poly(ε-caprolactone) nanoparticles for efficient drug delivery system

Cited by 165 publications

References 51 publications

Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with core-shelled structure

Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with core-shelled structure

Novel thermosensitive poly (N-isopropylacrylamide-co-vinylpyrrolidone-co-methacrylic acid) nanosystems for delivery of natural products.

Utilization of Acrylamide and Natural Polysaccharide Based Polymeric Networks in Ph Controlled Release of 5-Amino Salicylic Acid

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