Thermosensitive PNIPAM-b-HTPB block copolymer micelles: Molecular architectures and camptothecin drug release

Luo, Yan‐Ling; Yang, Xiaoli; Xu, Feng; Zhang, Bin

doi:10.1016/j.colsurfb.2013.09.043

Cited by 46 publications

(33 citation statements)

References 34 publications

(40 reference statements)

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“…The CPT-loaded hydrophobic cationic aminocellulose showed high encapsulation efficiency (approximately 86.4%, Table 1) compared with other CPT-loaded polymer micelles (e.g. 24.5%) (McCarron et al, 2008;Taki et al, 2012;Luo et al, 2014). The result suggested to the entrapped CPT is more effectively stabilised in the core of the micelle.…”

Section: Evaluation Of the Ee And In Vitro Cpt Release Profilesmentioning

confidence: 72%

Mucoadhesive drug carrier based on functional-modified cellulose as poorly water-soluble drug delivery system

Songsurang¹,

Siraleartmukul²,

Muangsin³

2015

Journal of Microencapsulation

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The purpose of this study was to design and characterise an oral mucoadhesive micellar drug carrier. In this regard, a mucoadhesive hydrophobic cationic aminocellulose was easily synthesised under mild homogeneous conditions with high yield. The cellulose derivative resulted in strongly improved mucoadhesive properties but was pH dependent. Furthermore, the hydrophobic anticancer drug camptothecin was successfully encapsulated into the mucoadhesive cellulose derivative micelles with spherical shape stability of 233 nm in diameter and low particle size distribution. The CPT-loaded nanocarriers provided high encapsulation efficiency about 86.4%. In vitro release, CPT-loaded cellulose derivative micelles showed a reduction in release rate compared with physically pure CPT solution. The release results also indicated that a sustained release of CPT to >80% over 4 d for pH 6.8 and 7.4. Therefore, mucoadhesive hydrophobic cationic aminocellulose micelles seem to be a promising carrier for various pharmaceutical applications especially for poorly water-soluble drug delivery system.

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Section: Evaluation Of the Ee And In Vitro Cpt Release Profilesmentioning

confidence: 72%

Mucoadhesive drug carrier based on functional-modified cellulose as poorly water-soluble drug delivery system

Songsurang¹,

Siraleartmukul²,

Muangsin³

2015

Journal of Microencapsulation

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“…Water insoluble CPT was loaded into the micelles as an anticancer drug which showed strong antitumor properties. 71,72 …”

Section: Different Stimuli-responsive Mnpsmentioning

confidence: 99%

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

et al. 2016

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New achievements in the realm of nanoscience and innovative techniques of nanomedicine have moved micro/nanoparticles (MNPs) to the point of becoming actually useful for practical applications in the near future. Various differences between the extracellular and intracellular environments of cancerous and normal cells and the particular characteristics of tumors such as physicochemical properties, neovasculature, elasticity, surface electrical charge, and pH have motivated the design and fabrication of inventive “smart” MNPs for stimulus-responsive controlled drug release. These novel MNPs can be tailored to be responsive to pH variations, redox potential, enzymatic activation, thermal gradients, magnetic fields, light, and ultrasound (US), or can even be responsive to dual or multi-combinations of different stimuli. This unparalleled capability has increased their importance as site-specific controlled drug delivery systems (DDSs) and has encouraged their rapid development in recent years. An in-depth understanding of the underlying mechanisms of these DDS approaches is expected to further contribute to this groundbreaking field of nanomedicine. Smart nanocarriers in the form of MNPs that can be triggered by internal or external stimulus are summarized and discussed in the present review, including pH-sensitive peptides and polymers, redox-responsive micelles and nanogels, thermo- or magnetic-responsive nanoparticles (NPs), mechanical- or electrical-responsive MNPs, light or ultrasound-sensitive particles, and multi-responsive MNPs including dual stimuli-sensitive nanosheets of graphene. This review highlights the recent advances of smart MNPs categorized according to their activation stimulus (physical, chemical, or biological) and looks forward to future pharmaceutical applications.

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“…The DMP nanoparticles in the hydrogel could clearly extend the drug residence time and increase drug concentrationi nt he bladder.T he outer hydrogel still maintained its gel property with flowing liquid state under 25 8Ca nd gelation at highert emperatures. The D/DMP-F system provided ap romising intravesical drug delivery for bladder cancer therapy.L uo et al [37] designedt wo kinds of thermo-sensitive poly(N-isoproplacrylamide) (PNIPAM) block copolymers with lower criticalm icelle concentrations and thermo-dependent size changes at 33-35 8C. The low critical solution temperature provided the micelles with temperatureinduced structural changes and thermo-responsive drugr elease behavior.W ang et al [38] synthesized at hermo-sensitive amphiphilic block copolymer with lower criticals olution temperature( LCST) at about 38 8C.…”

Section: Polymer-based Thermally Responsive Materialsmentioning

confidence: 99%

Thermally Responsive Materials for Bioimaging

Zuo

Gou

Zhang

et al. 2018

Chemistry An Asian Journal

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The last decade has witnessed multiple thermally responsive materials emerge as as ignificant class of stimuliresponsive materials. These materials are elaborately designed and exert interesting properties. Herein, an overview of thermally responsive materials with respectt od esign strategies, fabrication procedures,a nd their applicationsi s presented. Recently reported thermally responsive materials are highlighted.T hen, applications of thermally responsive materialsi nb ioimaging are summarized.[a] Dr.

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Thermosensitive PNIPAM-b-HTPB block copolymer micelles: Molecular architectures and camptothecin drug release

Cited by 46 publications

References 34 publications

Mucoadhesive drug carrier based on functional-modified cellulose as poorly water-soluble drug delivery system

Mucoadhesive drug carrier based on functional-modified cellulose as poorly water-soluble drug delivery system

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

Thermally Responsive Materials for Bioimaging

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