Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment

Gomes, Isabela Pereira; Duarte, Jaqueline Aparecida; Maia, Ana Luiza Chaves; Rubello, Domenico; Townsend, Danyelle M.; Barros, André Luís Branco de; Leite, Elaine Amaral

doi:10.3390/ph12040171

Cited by 31 publications

(26 citation statements)

References 101 publications

(179 reference statements)

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“…The impact of a pH shift is tested with elution conditions of PBS buffer at pH 5. Magnetic hyperthermia is a method in which the temperature can be increased up to 40-45 • C by the application of an alternating magnetic field to BIONs [62][63][64], though it is important to note that the agglomeration behavior of the BIONs can have a negative effect on its hyperthermia properties [65]. The desorption is analyzed under possible hyperthermia conditions at a temperature of 40 • C. The temperature sensitivity of the binding is also tested under extreme conditions of 60 • C. Figure 7a shows the effect of the different elution conditions after one hour of incubation.…”

Section: Desorption Of the Bound Peptides From Bionsmentioning

confidence: 99%

Bare Iron Oxide Nanoparticles as Drug Delivery Carrier for the Short Cationic Peptide Lasioglossin

2021

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New drug delivery systems are a potential solution for administering drugs to reduce common side effects of traditional methods, such as in cancer therapy. Iron oxide nanoparticles (IONs) can increase the drugs’ biological activity through high binding efficiency and magnetically targeted drug delivery. Understanding the adsorption and release process of a drug to the carrier material plays a significant role in research to generate an applicable and controlled drug delivery system. This contribution focuses on the binding patterns of the peptide lasioglossin III from bee venom on bare IONs. Lasioglossin has a high antimicrobial behavior and due to its cationic properties, it has high binding potential. Considering the influence of pH, the buffer type, the particle concentration, and time, the highest drug loading of 22.7% is achieved in phosphate-buffered saline. Analysis of the desorption conditions revealed temperature and salt concentration sensitivity. The nanoparticles and peptide-ION complexes are analyzed with dynamic light scattering, zeta potential, and infrared spectroscopy. Additionally, cytotoxicity experiments performed on Escherichia coli show higher antimicrobial activity of bound lasioglossin than of the free peptide. Therefore, bare IONs are an interesting platform material for the development of drug-delivery carriers for cationic peptides.

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Section: Desorption Of the Bound Peptides From Bionsmentioning

confidence: 99%

Bare Iron Oxide Nanoparticles as Drug Delivery Carrier for the Short Cationic Peptide Lasioglossin

2021

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“…Similarly to CLS, mild thermal treatment via NIR laser light is mainly suitable for superficial tumors [ 107 ]. On one hand, the laser system is more advanced than CLS.…”

Section: Hyperthermia Devicesmentioning

confidence: 99%

“…Therefore, it is essential to optimize the experimental settings, taking wavelength, beam size, and laser intensity into consideration. Similarly to CLS, mild thermal treatment via NIR laser light is mainly suitable for superficial tumors [107]. On one hand, the laser system is more advanced than CLS.…”

Section: Near-infrared (Nir) Laser Lightmentioning

confidence: 99%

External Basic Hyperthermia Devices for Preclinical Studies in Small Animals

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Rhoon

et al. 2021

Cancers

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Preclinical studies have shown that application of mild hyperthermia (40–43 °C) is a promising adjuvant to solid tumor treatment. To improve preclinical testing, enhance reproducibility, and allow comparison of the obtained results, it is crucial to have standardization of the available methods. Reproducibility of methods in and between research groups on the same techniques is crucial to have a better prediction of the clinical outcome and to improve new treatment strategies (for instance with heat-sensitive nanoparticles). Here we provide a preclinically oriented review on the use and applicability of basic hyperthermia systems available for solid tumor thermal treatment in small animals. The complexity of these techniques ranges from a simple, low-cost water bath approach, irradiation with light or lasers, to advanced ultrasound and capacitive heating devices.

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“…A photothermic agent acts transforming the absorbed energy by the photons into heat [83]. Considering that temperature is one of the most important parameters when determining cell dynamics and viability, PTT induced hyperthermia (over physiological conditions at 37 • C) can disturb tumor mass growth [97]. For this reason, PTT has become one of the preferential options to design nanotherapies for cancer research in the last decades.…”

Section: Swcnh In Photothermal and Photodynamic Cancer Therapymentioning

confidence: 99%

Single-Walled Carbon Nanohorns as Promising Nanotube-Derived Delivery Systems to Treat Cancer

2020

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Cancer has become one of the most prevalent diseases worldwide, with increasing incidence in recent years. Current pharmacological strategies are not tissue-specific therapies, which hampers their efficacy and results in toxicity in healthy organs. Carbon-based nanomaterials have emerged as promising nanoplatforms for the development of targeted delivery systems to treat diseased cells. Single-walled carbon nanohorns (SWCNH) are graphene-based horn-shaped nanostructure aggregates with a multitude of versatile features to be considered as suitable nanosystems for targeted drug delivery. They can be easily synthetized and functionalized to acquire the desired physicochemical characteristics, and no toxicological effects have been reported in vivo followed by their administration. This review focuses on the use of SWCNH as drug delivery systems for cancer therapy. Their main applications include their capacity to act as anticancer agents, their use as drug delivery systems for chemotherapeutics, photothermal and photodynamic therapy, gene therapy, and immunosensing. The structure, synthesis, and covalent and non-covalent functionalization of these nanoparticles is also discussed. Although SWCNH are in early preclinical research yet, these nanotube-derived nanostructures demonstrate an interesting versatility pointing them out as promising forthcoming drug delivery systems to target and treat cancer cells.

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Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment

Cited by 31 publications

References 101 publications

Bare Iron Oxide Nanoparticles as Drug Delivery Carrier for the Short Cationic Peptide Lasioglossin

Bare Iron Oxide Nanoparticles as Drug Delivery Carrier for the Short Cationic Peptide Lasioglossin

External Basic Hyperthermia Devices for Preclinical Studies in Small Animals

Single-Walled Carbon Nanohorns as Promising Nanotube-Derived Delivery Systems to Treat Cancer

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