Thermosensitive liposomes encapsulating hypericin: Characterization and photodynamic efficiency

Dayyih, Alice Abu; Alawak, Mohamad; Ayoub, Abdallah Mohamed; Amin, Muhammad; Dayyih, Wael Abu; Engelhardt, Konrad; Duse, Lili; Preis, Eduard; Brüßler, Jana; Bakowsky, Udo

doi:10.1016/j.ijpharm.2021.121195

Cited by 19 publications

(19 citation statements)

References 77 publications

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“…To investigate the in vitro antineoplastic activity of void TSL, p -SC4, ND-TSL, p -SC4-ND-TSL, P-TSL, and free ND, MDA-MB-231 cells were exposed to varying concentrations of loaded liposomal systems, free drug solutions, void liposomes, and p -SC4 solutions in triplicate. The viability of MDA-MB-231 cells was evaluated via MTT assay at 37 and 40 °C using our previously reported method …”

Section: Methodsmentioning

confidence: 99%

“…Thermosensitive polymers are water-soluble at body temperature, and upon application of the triggering temperature, they are converted into a hydrophobic state. Consequently, disruption of the liposomal membranes occurs, leading to cargo release. − Radiolabeled liposomes also show considerable potential for cancer therapy and diagnosis. The incorporation of α- or β-emitting radionuclides into liposomal lipid bilayers or their entrapment in liposomal inner aqueous cavities has been previously reported for their potential use in cancer therapy .…”

Section: Introductionmentioning

confidence: 99%

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Thermosensitive Liposomes Encapsulating Nedaplatin and Picoplatin Demonstrate Enhanced Cytotoxicity against Breast Cancer Cells

et al. 2022

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Thermosensitive liposomes (TSL) have been used for localized temperature-responsive release of chemotherapeutics into solid cancers, with a minimum of one invention currently in clinical trials (phase III). In this study, TSL was designed using a lipid blend comprising 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] (DSPE-PEG-2000) (molar ratio of 88:9:2.8:0.2). Either nedaplatin (ND) or p-sulfonatocalix[4]arene-nedaplatin was encapsulated in the aqueous inner layer of TSL to form (ND-TSL) or p-SC4-ND-TSL, respectively. The hydrophobic platinum-based drug picoplatin (P) was loaded into the external lipid bilayer of the TSL to develop P-TSL. The three nanosystems were studied in terms of size, PDI, surface charge, and on-shelf stability. Moreover, the entrapment efficiency (EE%) and release % at 37 and 40 °C were evaluated. In a 30 min in vitro release study, the maximum release of ND, p-SC4-ND, and picoplatin at 40 °C reached 74, 79, and 75%, respectively, compared to approximately 10% at 37 °C. This demonstrated temperature-triggered drug release from the TSL in all three developed systems. The designed TSL exhibited significant in vitro anticancer activity at 40 °C when tested on human mammary gland/breast adenocarcinoma cells (MDA-MB-231). The cytotoxicity of ND-TSL, p-SC4-ND-TSL, and P-TSL at 40 °C was approximately twice those observed at 37 °C. This study suggests that TSL is a promising nanoplatform for the temperaturetriggered release of platinum-based drugs into cancer cells.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thermosensitive Liposomes Encapsulating Nedaplatin and Picoplatin Demonstrate Enhanced Cytotoxicity against Breast Cancer Cells

et al. 2022

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“…The device can emit light at wavelengths of 457 nm and 652 nm for blue and red regions, respectively. The actual light dose (J/cm 2 ) = Irradiance (W/cm 2 ) × irradiation time (in sec) [33].…”

Section: Light Sourcementioning

confidence: 99%

Parietin Cyclodextrin-Inclusion Complex as an Effective Formulation for Bacterial Photoinactivation

et al. 2022

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Multidrug resistance in pathogenic bacteria has become a significant public health concern. As an alternative therapeutic option, antimicrobial photodynamic therapy (aPDT) can successfully eradicate antibiotic-resistant bacteria with a lower probability of developing resistance or systemic toxicity commonly associated with the standard antibiotic treatment. Parietin (PTN), also termed physcion, a natural anthraquinone, is a promising photosensitizer somewhat underrepresented in aPDT because of its poor water solubility and potential to aggregate in the biological environment. This study investigated whether the complexation of PTN with (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD) could increase its solubility, enhance its photophysical properties, and improve its phototoxicity against bacteria. At first, the solubilization behavior and complexation constant of the PTN/HP-β-CD inclusion complexes were evaluated by the phase solubility method. Then, the formation and physicochemical properties of PTN/HP-β-CD complexes were analyzed and confirmed in various ways. At the same time, the photodynamic activity was assessed by the uric acid method. The blue light-mediated photodegradation of PTN in its free and complexed forms were compared. Complexation of PTN increased the aqueous solubility 28-fold and the photostability compared to free PTN. PTN/HP-β-CD complexes reduce the bacterial viability of Staphylococcus saprophyticus and Escherichia coli by > 4.8 log and > 1.0 log after irradiation, respectively. Overall, the low solubility, aggregation potential, and photoinstability of PTN were overcome by its complexation in HP-β-CD, potentially opening up new opportunities for treating infections caused by multidrug-resistant bacteria.

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“…Photoresponsive liposomes have multiple advantages over other types of responsive liposomes. − For example, the central mechanism of temperature-responsive liposomes , is to alter the state transition of the membrane based on the critical phase transition temperature of a phospholipid or temperature-responsive polymer, resulting in increased permeability. There is some similarity in performance to photoresponsive liposomes partially dominated by photothermal effects.…”

Section: Comparison and Development Of Photoresponsive Liposomesmentioning

confidence: 99%

Recent Development of Photoresponsive Liposomes Based on Organic Photosensitizers, Au Nanoparticles, and Azobenzene Derivatives for Nanomedicine

Pan

et al. 2022

ACS Appl. Nano Mater.

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Photoresponsive liposomes are controlled-release liposomes modified by photoresponsive materials. They use light with high spatial and temporal precision as a means of regulation. After excitation by light at appropriate wavelengths, photoresponsive liposomes can influence the permeability of phospholipid bilayers through the photothermal or photoisomerization effect of photoresponsive materials. The photothermal effect causes the phospholipid layer to become dispersed by local heating, and the photoisomerization effect modulates the release behavior by establishing permeation channels on the phospholipid layer through changes in the dipole moments of azobenzene derivatives. Currently, photoresponsive liposomes are widely used as a cutting-edge strategy for nanomedicine. In this paper, three types of photoresponsive liposomes based on organic photosensitizers, Au nanoparticles, and azobenzene derivatives with abundant research reports were introduced based on the differences in the photoresponse principles and forms of different photoresponsive materials. This review aims to reflect the differences in the structures, properties, photoresponsive materials, and principles of action of different photoresponsive liposomes. Moreover, this work outlines the current status of their application in the field of nanomedicine.

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Thermosensitive liposomes encapsulating hypericin: Characterization and photodynamic efficiency

Cited by 19 publications

References 77 publications

Thermosensitive Liposomes Encapsulating Nedaplatin and Picoplatin Demonstrate Enhanced Cytotoxicity against Breast Cancer Cells

Thermosensitive Liposomes Encapsulating Nedaplatin and Picoplatin Demonstrate Enhanced Cytotoxicity against Breast Cancer Cells

Parietin Cyclodextrin-Inclusion Complex as an Effective Formulation for Bacterial Photoinactivation

Recent Development of Photoresponsive Liposomes Based on Organic Photosensitizers, Au Nanoparticles, and Azobenzene Derivatives for Nanomedicine

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