Thermosensitive hydrogels of poly(methyl vinyl ether-co-maleic anhydride) – Pluronic® F127 copolymers for controlled protein release

Moreno, Esther; Schwartz, Juana; Larrañeta, Eneko; Nguewa, Paul A.; Sanmartín, Carmen; Agüeros, Maite; Irache, Juan M.; Espuelas, Socorro

doi:10.1016/j.ijpharm.2013.11.030

Cited by 71 publications

(32 citation statements)

References 34 publications

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“…The capability to control the quantity, location and time of drug dosing is one of the main objectives in the design of drug delivery systems (37). For these purposes systems responsive to different stimulus, such as temperature, pH or light among others have been prepared (38)(39)(40)(41). A light triggered MN drug delivery system have been designed and successfully tested in vitro for the release of a clinical relevant model drug: ibuprofen.…”

Section: Discussionmentioning

confidence: 99%

Hydrogel-Forming Microneedle Arrays Made from Light-Responsive Materials for On-Demand Transdermal Drug Delivery

et al. 2016

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We describe, for the first time, stimulus-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 h). This makes the system appealing as a controlled release device for prolonged periods of time. We believe that this technology has potential for use in "on-demand" delivery of a wide range of drugs in a variety of applications relevant to enhanced patient care.

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Section: Discussionmentioning

confidence: 99%

Hydrogel-Forming Microneedle Arrays Made from Light-Responsive Materials for On-Demand Transdermal Drug Delivery

et al. 2016

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“…Due to their temperature-responsive behavior, these are also known as thermosensitive polymers. 175,[192][193][194][195] These polymers are inert in nature and are known to maintain the stability of incorporated therapeutic proteins and peptides with an increase in their survival period as compared to other sustained release drug delivery systems. 145,196,197 Other than having the efficient property to deliver therapeutic substances to the targets, these polymers have a diverse range of applications.…”

Section: Poly(lactic-co-glycolic Acid)mentioning

confidence: 99%

“…196,217,236 Pharmaceutical scientists have tried to evade this limitation of PF127 by making few physical and chemical modifications using other biodegradable polymers which may increase the residence time and mechanical properties that ultimately help prolong the sustained release of incorporated therapeutic proteins for a longer period of time compared to PF127 alone. 195,229,[237][238][239] Mechanical strength and the bioadhesive properties of PF127 have been also increased by conjugating PF127 with other mucoadhesive polymers. 44,226,240,241 2.2.5.…”

Section: Poly(lactic-co-glycolic Acid)mentioning

confidence: 99%

Natural and Synthetic Polymers as Drug Carriers for Delivery of Therapeutic Proteins

2015

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In order to cure and treat health-related disorders, therapeutic substance must reach its target site with a constant concentration over a long period of time. As oral administration is limited due to enzymatic degradation, most of the commercially available therapeutic proteins are usually being administered parenterally. However, because of their short biological half-life, daily multiple injections are required to maintain effective therapeutic levels of these drug candidates. To limit this drawback, a variety of polymers are being used to increase systemic bioavailability of therapeutic proteins and peptides. Development of protein-based therapeutic substances has tremendously increased the need for suitable polymeric-based carrier systems, guaranteeing safe and sustained delivery of therapeutic proteins to their target site. Here, we have briefly discussed two major types of polymers including natural and synthetic polymers that have been intensively studied for efficient delivery of various proteinous drugs. A wide variety of natural and/or synthetic polymers have been found to be useful and safe drug carrier systems for the delivery of therapeutic proteins which have been discussed over here in detail. To conclude, these polymers have been

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“…Numerous methods were successively developed for preparing TVPs to endow polymer solutions with thermothickening ability, besides graft modification in organic solvent, free radical copolymerization in bulk monomers, or different media such as aqueous solution, dodecane dispersion, micellar solution were also developed. In addition, the living radical polymerization was also employed to synthesize TVPs.…”

Section: Introductionmentioning

confidence: 99%

“…The materials with high content of macromonomer (>35%) were easily obtained. However, the existing free radical preparation methods still have their own disadvantages: first, the weight‐average molecular weight ( M w ) of TVPs reported to date is just up to 3.8 × 10 6 g·mol −1 , and the “thermothickening” effect could only be got at much high concentrations (1–5 wt %); second, the final solutions after polymerization always had high viscosity and even turned into gels, which induced a tough post processing; third, the strict condition of living radical polymerization is not suitable for industrial applications. These disadvantages not only impeded scaled‐up manufacturing of TVPs, but also limited their practical application.…”

Section: Introductionmentioning

confidence: 99%

Thermoviscosifying polymers based on polyether prepared from inverse emulsion polymerization

Wang

Sun

Han

et al. 2018

J of Applied Polymer Sci

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Thermoviscosifying polymers are attractive for enhancing oil recovery owing to their exceptional thickening power as temperature increases. However, the polymers reported to date show inadequacies including obligatory high polymer concentration to get the thermothickening ability because of their low molecular weight (MW), and inconvenient post-treatment due to the high viscosity after manufacturing. To overcome these drawbacks, inverse emulsion polymerization was used here for preparing polyether-based thermoviscosifying polymers (TVP-Ps) by grafting acrylic monomers onto triblock copolymers PEO-PPO-PEO. It was found the MW of final products could reach 8 million Daltons, making them thermoviscosifying at 0.2 wt %. The viscosity of polymerized inverse emulsions was as low as 175 mPaÁs, leading to direct dispersing. The TVP-Ps containing Pluronic F127, F108, F68 all exhibited significant thermothickening behaviors in both aqueous solutions and brines, and the critical thermoassociative temperature could be tuned by changing the nature or amount of Pluronics. After aging at 45 8C for 60 days with equal initial viscosity, TVP-Ps shows 21% higher viscosity retention than the reference polymer without Pluronic, PAMA, and preliminary core flooding test demonstrated TVP-Ps can get 2.1% higher incremental oil recovery than PAMA. This work paves a new avenue for scaled-up preparation and potential use of TVP-Ps. potential use of TVP-Ps.

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Thermosensitive hydrogels of poly(methyl vinyl ether-co-maleic anhydride) – Pluronic® F127 copolymers for controlled protein release

Cited by 71 publications

References 34 publications

Hydrogel-Forming Microneedle Arrays Made from Light-Responsive Materials for On-Demand Transdermal Drug Delivery

Hydrogel-Forming Microneedle Arrays Made from Light-Responsive Materials for On-Demand Transdermal Drug Delivery

Natural and Synthetic Polymers as Drug Carriers for Delivery of Therapeutic Proteins

Thermoviscosifying polymers based on polyether prepared from inverse emulsion polymerization

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