Thermosensitive folic acid-targeted poly (ethylene-co-vinyl alcohol) hemisuccinate polymeric nanoparticles for delivery of epirubicin to breast cancer cells

Hassanzadeh, Farshid; Maaleki, Sahar; Varshosaz, Jaleh; Khodarahmi, Ghadam Ali; Farzan, Maryam; Rostami, Mahboubeh

doi:10.1007/s13726-016-0483-z

Cited by 10 publications

(3 citation statements)

References 43 publications

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“…Nevertheless, a considerable amount of drug (71.7 ± 8.1%, 59.1 ± 16.4% and 42.1 ± 5.0% for EVOH32, EVOH38 and EVOH44, respectively) was released from the fibers at 25 °C when compared to the study of Hassanzadeh et al where most of the drug remained within the nanoparticles at low temperatures. 28 Such a difference between the release profiles could be explained by the fabrication process of the fibers leading to the aforementioned migration of IBU to the surface of the NFs. Two competing mechanisms can explain this temperature sensitivity.…”

Section: Resultsmentioning

confidence: 99%

“…[25][26][27] Particularly, Hassanzadeh et al have reported the fabrication of folic acid-targeted succinylated EVOH nanoparticles and demonstrated a higher release of epirubicin as a function of temperature. 28 The release kinetics were explained by the structural degradation of EVOH at higher temperatures, leading to the release of epirubicin, thus revealing the critical impact of nanoscale structural changes for drug release application of this material. Furthermore, by adjusting the ratio of vinyl alcohol to ethylene segments, the thermal and mechanical properties of the copolymer can be finely tuned for the desired purpose.…”

Section: Introductionmentioning

confidence: 98%

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Ibuprofen-loaded electrospun poly(ethylene-co-vinyl alcohol) nanofibers for wound dressing applications

et al. 2023

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Ibuprofen-loaded electrospun poly(ethylene-co-vinyl alcohol) nanofibers for wound dressing applications

et al. 2023

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“…Bauer et. al [92] compared the cubic and spherical MNPs, with similar magnetic volumes. They showed that the MNP with cubic shape has higher SAR value (362 W/g) compared to that of the MNP with spherical shape (189.6 W/g).…”

Section: Magnetothermally Responsive Nanomaterials For Therapy Applicmentioning

confidence: 99%

Photo‐ and Magnetothermally Responsive Nanomaterials for Therapy, Controlled Drug Delivery and Imaging Applications

et al. 2020

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Hyperthermia generates heat as a cure for illness and it is not a chemical treatment. Nanomaterials are supposed to provide novel mechanisms to tackle photothermal and magnetothermal problems, with the potential also to deal with specific approaches to care. The present review outlines recent developments in the field of photothermal and magnetothermal responsive nanomaterials and the photothermal approach mechanism over the last years. These photo/magnetothermal nanomaterials are classified into gold nanostructures (various shapes), carbon nanomaterials (CNTs, fullerene, carbon quantum dots, and graphene), inorganic nanomaterials (Fe, Pt, Pd, Bi, MOF, MoSe2, inorganic quantum dots, etc.) and organic nanoparticles (PLGA (Poly Lactic‐co‐Glycolic Acid) and other nanopolymers). Different groups may be placed together to improve the potential of the photothermal/magnetothermal effects, treatments, drug delivery, and imaging. The review also describes synthesis strategies for photothermal/magnetothermal nanomaterials, physicochemical characterization, the role of size, size distribution, shape, and surface coating of nanomaterials, challenges, and future scopes of photothermal/magnetothermal responsive nanomaterials for therapy, controlled drug delivery, and imaging applications. The recent development in nanomaterial has shown great potential for tumor diagnostic and therapeutic applications in hyperthermia. Magnetic hyperthermia (also called thermal therapy or thermotherapy) is a type of cancer treatment in which body tissue is exposed to high temperatures (up to 41 °C) in presence of a magnetic field. Research has shown that high temperatures can damage and kill cancer cells, usually with minimal injury to normal tissues. By killing cancer cells and damaging proteins and structures within cells, hyperthermia can necrotize tumor cells. This treatment can be local, regional, or whole‐body hyperthermia, depending on the extent of the area being treated. Hyperthermia can be combined with anticancer drugs or chemotherapy to enhance cancer treatment. In this article, we have discussed recent nanomaterials utilized for this treatment, mechanism, and synthesis methods.

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Development of a novel thermo-responsive hydrogel-coated gold nanorods as a drug delivery system

2018

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Thermosensitive folic acid-targeted poly (ethylene-co-vinyl alcohol) hemisuccinate polymeric nanoparticles for delivery of epirubicin to breast cancer cells

Cited by 10 publications

References 43 publications

Ibuprofen-loaded electrospun poly(ethylene-co-vinyl alcohol) nanofibers for wound dressing applications

Ibuprofen-loaded electrospun poly(ethylene-co-vinyl alcohol) nanofibers for wound dressing applications

Photo‐ and Magnetothermally Responsive Nanomaterials for Therapy, Controlled Drug Delivery and Imaging Applications

Development of a novel thermo-responsive hydrogel-coated gold nanorods as a drug delivery system

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