Thermoreversible hydrogels. IV. Effect of some factors on the swelling behavior ofN-tetrahydrofurfurylacrylamide

Abstract

A thermoreversible hydrogel, poly(N-tetrahydrofurfurylacrylamide) [poly-(NTHFAAm) gel], was prepared from N-tetrahydrofurfurylacrylamide, which was synthesized from N-tetrahydrofurfurylamine and acryloyl chloride (through acylation), with N,N-methylenebisacrylamide, a crosslinker, in various aqueous solutions. The influences of temperature, gel thickness, and polymerization media on the swelling behaviors in water were investigated. The effect of the gel thickness on the swelling ratio for NTHFAAm gel indicated that the equilibrium swelling time and diffusion coefficient for the thinner gel were faster than those for the thicker gels. The effects of different polymerization media on the gel swelling ratio showed that the larger the solvent molecular size and the poorer the miscibility of the monomer and solvent, the higher the swelling ratio and diffusion coefficient. The drug release profiles in the various gels were also investigated.

Preparation and characterization of water-swellable natural rubbers

“…Increase in the amount of surfactants of SPAN 60 and EC reduced the mean particle diameters from 212 to 76 m, because more micelles were stabilized in their dispersion. [15][16][17][18][19] Thus the increase in the NaCl concentration in the solution phase reduced ionic contribution to swelling pressure, resulting in less water absorption. Figure 5 shows the thermogravimetric analysis of sodium polyacrylates.…”

Modulation in Sorption Dynamics of a pH‐Sensitive Interpenetrating Polymer Network (IPN)

“…[27] The penetration velocity was calculated from the slope of the initial portion of the water uptake curve by the following: The solvent sorption rate indicates the solvent uptake per unit time and is directly related to the equilibrium swelling.…”

“…[49] When the concentration of crosslinker (MBA) increases in the feed mixture, the value of n decrease below the Fickian value, thus suggesting a decreasing Fickian process. The observed non-Fickian swelling could be attributed to the greater water sorption by the IPN because of increasing chain relaxation due to existing repulsive forces.…”

Thermoreversible hydrogels XIV. Synthesis and swelling behavior of the (n-isopropylacrylamide-co-2-hydroxyethyl methacrylate) copolymeric hydrogels

“…34 A series of acrylamide-derivative gels prepared in various polymerization media were investigated in our previous report, such as N,Ndimethyl acrylamide/n-butoxymethyl acrylamide, (DMA/nBMA) and N-tetrahydrofurfuryl acrylamide (NTHF AAm). 37,38 Hence, a series of NIPAAm/HEMA copolymeric gels were prepared in acetone aqueous solution and ethanol aqueous solution in an attempt to investigate the swelling behaviors for these copolymeric gels in various aqueous solutions, and the gels were prepared in various polymerization media and applied in drug release.…”