Thermoresponsive β-glucan-based polymers for bimodal immunoradiotherapy – Are they able to promote the immune system?

Fluorine polymer probes for magnetic resonance imaging: quo vadis?

“…As the components become less mobile, the relaxation times are shortened. These aggregation properties can be implemented in the creation of solid implants without the need for surgical intervention [40, 95].…”

“…Fluorinated thermoresponsive polymers can also be implemented for sustained release of drugs from implants, which are created upon injection into the body [105]. Typically, the polymers are injected in an aqueous solution, and after heating to body temperature, which is above the CPT, they form a depot [95, 106]. Above the LCST, the polymers precipitate, and after phase separation, they create a solid depot without surgery [95].…”

“…Typically, the polymers are injected in an aqueous solution, and after heating to body temperature, which is above the CPT, they form a depot [95, 106]. Above the LCST, the polymers precipitate, and after phase separation, they create a solid depot without surgery [95]. Moreover, if the polymers contain 19 F atoms, the localization, size and biodegradation of the implants can be monitored by 19 F MRI with high sensitivity due to the high local 19 F concentration at the injection site.…”

Copolymer chain formation of 2-oxazolines by in situ1H-NMR spectroscopy: dependence of sequential composition on substituent structure and monomer ratios

“…Polyoxazolines can be easily synthesized by living cationic ring-opening polymerization (CROP) of 2-substituted-2-oxazolines, usually initiated by tosylates or other electrophilic compounds. 8,19,30,31 Well-defined POx with relatively narrow dispersity index ( Đ ) ∼1.2 or even less 27 are obtained. Variation of the Ox-substituent controls hydrophilicity 32,33 of the final polymer or allows for post-polymerization modification of the POx backbone.…”

19F Magnetic Resonance Imaging of Injectable Polymeric Implants with Multiresponsive Behavior

“…Upon heating to body temperature, the polymer rapidly loses its hydration layer and precipitates, forming a solid implant without need of surgical intervention. 7,8 The in situ aggregated polymer is in equilibrium with a low amount of dissolved polymer, which is subsequently excreted by the lymphatic system into urine (renal route) or feces (hepatobiliary route), causing gradual dissolution of the implant. 9 Recently, these implants have been used as depot formulations for sustained release of hydrophobic drugs, which are entrapped in the depot by noncovalent interactions and are gradually released upon the depot degradation.…”