Thermoresponsive poly(N-isopropylacrylamide) copolymer networks for galantamine hydrobromide delivery

Georgieva, Dilyana; Ivanova-Mileva, Krasimira; Ivanova, Sijka; Kostova, Bistra; Rachev, Dimitar; Christova, Darinka

doi:10.1007/s00396-020-04621-8

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…In vitro, GLT release studies showed a considerable amount of GLT released from the different networks in the first hour. The highest release rate was found for the network obtained by redox polymerization with lower cross linker content, which was attributed to the network structure and high GLT content [ 266 ].…”

Section: Therapymentioning

confidence: 99%

Amyloid β, Lipid Metabolism, Basal Cholinergic System, and Therapeutics in Alzheimer’s Disease

Campos-Peña

Pichardo-Rojas

Sánchez-Barbosa

et al. 2022

IJMS

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The presence of insoluble aggregates of amyloid β (Aβ) in the form of neuritic plaques (NPs) is one of the main features that define Alzheimer’s disease. Studies have suggested that the accumulation of these peptides in the brain significantly contributes to extensive neuronal loss. Furthermore, the content and distribution of cholesterol in the membrane have been shown to have an important effect on the production and subsequent accumulation of Aβ peptides in the plasma membrane, contributing to dysfunction and neuronal death. The monomeric forms of these membrane-bound peptides undergo several conformational changes, ranging from oligomeric forms to beta-sheet structures, each presenting different levels of toxicity. Aβ peptides can be internalized by particular receptors and trigger changes from Tau phosphorylation to alterations in cognitive function, through dysfunction of the cholinergic system. The goal of this review is to summarize the current knowledge on the role of lipids in Alzheimer’s disease and their relationship with the basal cholinergic system, as well as potential disease-modifying therapies.

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Section: Therapymentioning

confidence: 99%

Amyloid β, Lipid Metabolism, Basal Cholinergic System, and Therapeutics in Alzheimer’s Disease

Campos-Peña

Pichardo-Rojas

Sánchez-Barbosa

et al. 2022

IJMS

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“…Stimuli-responsive hydrogels can undergo changes in their physical, mechanical, or chemical properties when exposed to stimuli such as light, or changes in temperature or pH. , For example, hydrogels incorporating thermo-responsive poly( N -isopropylacrylamide) (PNIPAM) undergo a volume phase transition near the lower critical solution temperature, resulting in reversible shrinking and swelling of the hydrogel . This property has enabled the use of PNIPAM-based hydrogels in applications such as controlled drug delivery, , sensors, and microfluidic channels. , Hydrogels with pH-sensitive ionizable pendent groups have also been extensively explored . Ionization of the pendent ionic groups promotes swelling of the hydrogel, while in the uncharged state, the hydrogel network contracts.…”

Section: Introductionmentioning

confidence: 99%

Self-Immolative Hydrogels with Stimulus-Mediated On–Off Degradation

2023

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Hydrogels are of interest for a wide range of applications from sensors to drug delivery and tissue engineering. Self-immolative polymers, which depolymerize from end-to-end following a single backbone or end-cap cleavage, offer advantages such as amplification of the stimulus-mediated cleavage event through a cascade degradation process. It is also possible to change the active stimulus by changing only a single end-cap or linker unit. However, there are very few examples of self-immolative polymer hydrogels, and the reported examples exhibited relatively poor stability in their nontriggered state or slow degradation after triggering. Described here is the preparation of hydrogels composed of self-immolative poly(ethyl glyoxylate) (PEtG) and poly(ethylene glycol) (PEG). Hydrogels formed from 2 kg/mol 4-arm PEG and 1.2 kg/mol PEtG with a light-responsive linker end-cap had high gel content (90%), an equilibrium water content of 89%, and a compressive modulus of 26 kPa. The hydrogel degradation could be turned on and off repeatedly through alternating cycles of irradiation and dark storage. Similar cycles could also be used to control the release of the anti-inflammatory drug celecoxib. These results demonstrate the potential for self-immolative hydrogels to afford a high degree of control over responses to stimuli in the context of smart materials for a variety of applications.

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“…Hydrogels are advantageous delivery systems for hydrophilic drugs because dissolved drugs could be included in the swollen cross-linked polymer matrix [ 29 , 30 , 31 ]. A variety of network structures could be used for the development of hydrogels suitable for dermal drug delivery applications, including copolymer architectures [ 38 , 39 , 40 ] and interpenetrating (IPN) and semi-interpenetrating networks [ 41 , 42 , 43 ]. A high swelling capacity in water and in body liquids of the networks, which reduces the irritancy of the carrier, is of prime importance, along with the general requirements for biocompatibility and non-toxicity.…”

Section: Introductionmentioning

confidence: 99%

Conceptualization and Investigation of Multicomponent Polymer Networks as Prospective Corticosteroid Carriers

Georgieva

Alexandrova

Ivanova

et al. 2023

Gels

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Dexamethasone (DXM) is a highly potent and long-acting synthetic glucocorticoid with anti-inflammatory, anti-allergic, and immunosuppressive effects. However, the systemic application of DXM can cause undesirable side effects: sleep disorders, nervousness, heart rhythm disorders, heart attack, and others. In the present study, multicomponent polymer networks were developed as potential new platforms for the dermal application of dexamethasone sodium phosphate (DSP). First, a copolymer network (CPN) comprising hydrophilic segments of different chemical structures was synthesized by applying redox polymerization of dimethyl acrylamide onto poly(ethylene glycol) in the presence of poly(ethylene glycol) diacrylate (PEGDA) as a crosslinker. On this basis, an interpenetrating polymer network structure (IPN) was obtained by introducing a second network of PEGDA-crosslinked poly(N-isopropylacrylamide). Multicomponent networks obtained were characterized by FTIR, TGA, and swelling kinetics in different solvents. Both CPN and IPN showed a high swelling degree in aqueous media (up to 1800 and 1200%, respectively), reaching the equilibrium swelling within 24 h. Additionally, IPN showed temperature-responsive swelling in an aqueous solution as the equilibrium swelling degree decreased considerably with an increase in the temperature. In order to evaluate the networks’ potential as drug carriers, swelling in DSP aqueous solutions of varied concentration was investigated. It was established that the amount of encapsulated DSP could be easily controlled by the concentration of drug aqueous solution. In vitro DSP release was studied in buffer solution (BS) with pH 7.4 at 37 °C. The results obtained during DSP loading and release experiments proved the feasibility of the developed multicomponent hydrophilic polymer networks as effective platforms for potential dermal application.

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Thermoresponsive poly(N-isopropylacrylamide) copolymer networks for galantamine hydrobromide delivery

Cited by 7 publications

References 31 publications

Amyloid β, Lipid Metabolism, Basal Cholinergic System, and Therapeutics in Alzheimer’s Disease

Amyloid β, Lipid Metabolism, Basal Cholinergic System, and Therapeutics in Alzheimer’s Disease

Self-Immolative Hydrogels with Stimulus-Mediated On–Off Degradation

Conceptualization and Investigation of Multicomponent Polymer Networks as Prospective Corticosteroid Carriers

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