Thermoresponsive Poly (<i>N</i>‐Isopropylacrylamide)/Polycaprolacton Nanofibrous Scaffolds for Controlled Release of Antibiotics

Arroub, Karim; Gessner, Isabel; Fischer, Thomas; Mathur, Sanjay

doi:10.1002/adem.202100221

Cited by 13 publications

(7 citation statements)

References 34 publications

(47 reference statements)

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“…Various hydrogel-based dosage forms based on TSHs have been developed to better target and control the current systems. [111] In the ophthalmic field, the low bioavailability of eye drops due to rapid clearance action induced by tear dilution and the lacrimal drainage system represents a limitation. Luo et al [112] demonstrated effective topical treatment of dry eye disease (DED) through a mucoadhesive drug delivery system based on TSHs.…”

Section: Thermosensitive Hydrogels In Drug Delivery Systems (Dds) App...mentioning

confidence: 99%

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Recent Advances in Poly(N‐isopropylacrylamide) Hydrogels and Derivatives as Promising Materials for Biomedical and Engineering Emerging Applications

et al. 2023

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Temperature‐sensitive (thermosensitive) hydrogels, which are part of the family of stimulus‐sensitive hydrogels, consist of water‐filled polymer networks that display a temperature‐dependent degree of swelling. Thermosensitive hydrogels, which can undergo phase transition or swell/de‐swell as temperature changes, have great potential in various technological and biomedical purposes for a number of reasons: their temperature response is reversible, hydrogels are stable and easy to prepare, they can be biocompatible and also be suitably combined with other organic and inorganic materials, resulting in new materials with outstanding properties. Among thermosensitive hydrogels poly(N‐isopropylacrylamide) (PNIPAAm) is the most extensively studied because it brings together the best properties of these materials. Consequently, in the past few years, a wide number of applications and new chemical processes to prepare PNIPAAm and their derivatives are being proposed. The objective of this review is to summarize the fundamentals of thermosensitive hydrogels and recent advances in preparation and both technological and biomedical applications of thermosensitive hydrogel, with a special focus on PNIPAAm and their derivatives. Special attention has been given to the discussion of challenges and future research perspectives based on new horizons not yet considered.

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Section: Thermosensitive Hydrogels In Drug Delivery Systems (Dds) App...mentioning

confidence: 99%

“…Various hydrogel‐based dosage forms based on TSHs have been developed to better target and control the current systems. [ 111 ]…”

Section: Biomedical Emerging Applications Of Poly(n‐isopropylacrylami...mentioning

confidence: 99%

Recent Advances in Poly(N‐isopropylacrylamide) Hydrogels and Derivatives as Promising Materials for Biomedical and Engineering Emerging Applications

et al. 2023

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“…[ 120 ] In another research, a PCL nanofibrous surface was functionalized by coating the fibrous matrix with thermo‐responsive PNIPAAm crosslinked in situ under UV light. [ 121 ]…”

Section: Thermoresponsive Electrospun Fibersmentioning

confidence: 99%

Thermoactive Smart Electrospun Nanofibers

Liguori

Pandini²,

Rinoldi

et al. 2022

Macromol. Rapid Commun.

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The recent burst of research on smart materials is a clear evidence of the growing interest of the scientific community, industry, and society in the field.The exploitation of the great potential of stimuli-responsive materials for sensing, actuation, logic, and control applications is favored and supported by new manufacturing technologies, such as electrospinning, that allows to endow smart materials with micro-and nanostructuration, thus opening up additional and unprecedented prospects. In this wide and lively scenario, this article systematically reviews the current advances in the development of thermoactive electrospun fibers and textiles, sorting them, according to their response to the thermal stimulus. Hence, several platforms including thermoresponsive systems, shape memory polymers, thermo-optically responsive systems, phase change materials, thermoelectric materials, and pyroelectric materials, are described and critically discussed. The difference in active species and outputs of the aforementioned categories is highlighted, evidencing the transversal nature of temperature stimulus. Moreover, the potential of novel thermoactive materials are pointed out, revealing how their development could take to utmost interesting achievements.

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“…Wound dressings made of nanofiber polymers with antibacterial effects and skin regeneration capabilities are good choices for preventing wound infection and speeding wound healing. [183][184][185][186][187][188][189][190][191][192] Antimicrobial agents have been applied to nanofibers to boost their antimicrobial activity. Antimicrobial substances, both inorganic and organic, have been used to achieve this aim.…”

Section: Polymer Advantages and Limitationsmentioning

confidence: 99%

Antimicrobial Synthetic and Natural Polymeric Nanofibers as Wound Dressing: A Review

et al. 2022

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Since ancient times, wound dressings have experienced many significant improvements. Evolution began using natural materials to merely cover wounds and advanced to used innovative techniques that can be customized to perform different impressive functions. Recent wound dressings, which are made of electrospun polymers, contain different active compounds, such as antimicrobial agents, that aid in wound healing and prevent dehydration and infection. The mentioned issues may influence the healing process, leading even to serious health risks for the patients. As a result, scientists are now working on novel wound bandages with improved antimicrobial properties. Electrospun polymeric nanofibers, because of their structural similarities to normal skin's extracellular matrix (ECM), bactericidal activity, and appropriateness to distribute bioactive molecules to the wound location, are regarded as good resources for enhancing skin regeneration and controlling wound infection. Herein, the latest findings on approaches for producing antimicrobial polymeric nanofibers using electrospinning and related processes are discussed. Recent advances in antibacterial biopolymeric nanofibers incorporating antimicrobial nanoparticles (silver, zinc oxide, copper oxide, etc.) are discussed. This review paper may raise significant issues, encourage additional research, and offer important insight into the potential area of antibacterial polymeric fibers.

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Thermoresponsive Poly (N‐Isopropylacrylamide)/Polycaprolacton Nanofibrous Scaffolds for Controlled Release of Antibiotics

Cited by 13 publications

References 34 publications

Recent Advances in Poly(N‐isopropylacrylamide) Hydrogels and Derivatives as Promising Materials for Biomedical and Engineering Emerging Applications

Recent Advances in Poly(N‐isopropylacrylamide) Hydrogels and Derivatives as Promising Materials for Biomedical and Engineering Emerging Applications

Thermoactive Smart Electrospun Nanofibers

Antimicrobial Synthetic and Natural Polymeric Nanofibers as Wound Dressing: A Review

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