Thermoresponsive P(HEMA-<i>co</i>-OEGMA) copolymers: synthesis, characteristics and solution behavior

Kasprów, Maciej; Machnik, Justyna; Otulakowski, Łukasz; Dworak, Andrzej; Trzebicka, Barbara

doi:10.1039/c9ra09668j

Cited by 19 publications

(26 citation statements)

References 62 publications

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“…The T CP values determined for the polymers in water are given in Table 1 . As can be expected, the obtained T CP values are in good agreement with those previously reported [ 39 , 40 , 52 ].…”

Section: Resultssupporting

confidence: 92%

“…In separate experiments, the PBS solutions of the studied polymers were heated only to temperatures slightly (1–2 °C) below the minimum value observed on the transmittance curves. This was similar to that observed previously for poly[2-hydroxyethyl methacrylate- co -oligo(ethylene glycol) methacrylate] by Kasprów et al [ 39 ]. All of the (co)polymers studied using this procedure showed reversible cloudy-to-transparent phase behaviour with no signs of precipitation.…”

Section: Resultssupporting

confidence: 92%

“…Thermoresponsive P(HEMA- co -OEGMA) has been synthesised by our group and characterised with special attention paid to its behaviour in water and PBS solutions. The control of the HEMA content in the copolymer allowed us to tune the T CP [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

“…P(IPO- co -NPO) (M n = 51,000 g/mol and M w /M n = 1.3) was synthesised via cationic ring-opening polymerisation initiated by methyl 4-nitrobenzenesulfonate at the Centre of Polymer and Carbon Materials, Polish Academy of Sciences, as previously shown in [ 40 ]. P(HEMA- co -OEGMA 300 ) with 79.7% mol of HEMA and 20.3% mol of OEGMA 300 and M n = 33,000 g/mol (M w /M n = 1.2) was synthesised at the Centre of Polymer and Carbon Materials at the Polish Academy of Sciences via atom transfer radical polymerisation as described in [ 39 ]. The molar mass of polymers was determined using gel permeation chromatography with a multiangle light scattering detector, which was considered to deliver their absolute values.…”

Section: Methodsmentioning

confidence: 99%

“…In our previous work [ 39 ], the synthesis and thermal behaviour of a set of poly[(2-hydroxyetyl)methacrylate- co -oligo(ethylene glycol) methacrylate] (P(HEMA- co -OEGMA 300 )) copolymers weredescribed. In PBS, the copolymers showed thermal transitions followed by a significant transmittance increase above T CP .…”

Section: Introductionmentioning

confidence: 99%

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Thermal Behaviour of Common Thermoresponsive Polymers in Phosphate Buffer and in Its Salt Solutions

et al. 2020

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Thermoresponsive polymers are a promising material for drug nanocarrier preparation, which makes the study of their aggregation in physiological conditions very important. In this paper, the thermal behaviour of the thermoresponsive polymers poly(N-isopropylacrylamide), poly(2-isopropyl-2-oxazoline-co-2-n-propyl-2-oxazoline) and poly[(2-hydroxyethyl methacrylate)-co-oligo(ethylene glycol) methyl ether methacrylate] were studied in phosphate buffer (PBS) and solutions of its salts in concentration as in PBS. The thermal response of the polymers was measured using UV-Vis and dynamic light scattering (DLS). The salts shifted the cloud point temperature (TCP) of the (co)polymers to higher values compared to the TCP of aqueous polymer solutions. In PBS and NaCl solutions, all polymers exhibited an unexpected and previously unreported transmittance profile. During heating, an additional aggregation of polymers appeared above the TCP accompanied by the formation of a precipitate. In monosodium phosphate solutions and pure water, the studied polymers showed lower critical solution temperature (LCST-type) behaviour. DLS measurements showed that a salt influenced the size of the resulting polymer particles. The sizes and stability of particles depended on the heating rate. In PBS and NaCl solutions, the size of particles in the dispersion decreased above 60 °C, and the precipitate appeared on the bottom of the cuvette. The additional aggregation of polymer and its falling out of solution may hinder the removal of carriers from the body and has to be taken into account when preparing nanocarriers.

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Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thermal Behaviour of Common Thermoresponsive Polymers in Phosphate Buffer and in Its Salt Solutions

et al. 2020

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Synthesis of doxorubicin‐loaded PBMA‐b‐POEGMA micelles and assessment of its anticancer activity against breast cancer cells (4T1)

Gharnas-ghamesh

Masoumi

Erfani‐Moghadam

2022

J of Applied Polymer Sci

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Doxorubicin (DOX) is a chemotherapy drug that possesses many side effects. This study aimed to synthesize PBMA‐b‐POEGMA [poly (butyl methacrylate)‐b‐poly (oligo ethylene glycol methacrylate)] diblock copolymer as a nanocarrier for loading of DOX, promoting anticancer efficacy of the drug, and decreasing its side effects. Hence, PBMA‐b‐POEGMA diblock copolymer was first synthesized by the RAFT method and then DOX encapsulated into the micellar nanocarrier. Self‐assembly behavior of copolymers and physicochemical/biological properties of nanocarriers were assessed. DLS and TEM images showed nanocarriers possessed spherical‐uniform structure with the mean size and polydispersity of 27 ± 1.34 nm and 0.13 ± 0.21 for blank‐micelles as well as, 45 ± 2.32 nm and 0.18 ± 0.18 for DOX‐loaded micelles, respectively. Synthesized micelles also provided high drug encapsulation efficiency (>80%) with a drug loading content of 4.53%. Moreover, the maximum released amount of drug was reported at 69%, with the Korsmeyer‐Peppas model, as a more suitable model to describe the release behavior of DOX from nanocarriers. Biologically, block copolymers were biocompatible against COS‐7 and 4T1 cell lines, in addition, free‐DOX showed higher cytotoxicity than DOX‐loaded micelles. Furthermore, 0.5 μg/mL concentration of drug‐loaded micelle led to growth inhibition of more than 60% of cancerous cells, during 48 h, so that higher level of cellular uptake of drug and apoptosis in 4T1 cells was induced by drug‐loaded micelles.

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Hydroxypropyl methacrylate stars as versatile carriers of therapeutic agents

Sentoukas,

Forys,

Otulakowski

et al. 2024

J of Applied Polymer Sci

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Three star‐like carriers with poly(hydroxy propyl methacrylate) (PHPMA) cores and poly(oligoethylene glycol methacrylate) (POEGMA) arms as nanocarriers were utilized for the encapsulation of rhodamine B, resveratrol, and curcumin. These drugs differ in hydrophobicity and therapeutic effects. The carriers had high encapsulation and loading efficiency (>95% and 10 wt%, respectively) and formed hydrogen bonds with the drugs. They were spherical in phosphate buffer saline and formed aggregates of various sizes (11–116 nm) depending on the star composition and the drug type. The carriers were stable for 2 months, but released different amounts of drugs afterwards, except for curcumin, which stayed entrapped. The curcumin‐loaded carriers also generated reactive oxygen species. These findings demonstrate the versatility of PHPMA/POEGMA stars as nanocarriers for diverse applications in nanomedicine.

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Thermoresponsive P(HEMA-co-OEGMA) copolymers: synthesis, characteristics and solution behavior

Abstract: Random, thermoresponsive copolymers of 2-hydroxyethyl methacrylate (HEMA) and oligo(ethylene glycol) methyl ether methacrylate Mn = 300 (OEGMA) were synthesized via ATRP and theirs behavior was studied in water and in buffer solution.

Cited by 19 publications

References 62 publications

Thermal Behaviour of Common Thermoresponsive Polymers in Phosphate Buffer and in Its Salt Solutions

Thermal Behaviour of Common Thermoresponsive Polymers in Phosphate Buffer and in Its Salt Solutions

Synthesis of doxorubicin‐loaded PBMA‐b‐POEGMA micelles and assessment of its anticancer activity against breast cancer cells (4T1)

Hydroxypropyl methacrylate stars as versatile carriers of therapeutic agents

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