Thermoresponsive nanofibers loaded with antimicrobial α-aminophosphonate-o/w emulsion supported by cellulose nanocrystals for smart wound care patches

Elsherbiny, Dalia A.; Abdelgawad, Abdelrahman M.; Shaheen, Tharwat I.; Abdelwahed, Nayera A. M.; Jockenhoevel, Stefan; Ghazanfari, Samaneh

doi:10.1016/j.ijbiomac.2023.123655

Cited by 13 publications

(9 citation statements)

References 63 publications

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“…However, a majority of them are toxic, expensive, and have to be used in stoichiometric amounts. Moreover, reported methods suffer from some drawbacks, such In the last decade, α-aminophosphonates were intensively studied as a significant group of compounds because of their high biological activity [19][20][21], which broadens their applicability in agricultural and medicinal chemistry. Organophosphorus compounds are known for their antimicrobial activity (alafosfalin); for example, dialkyl αaminophosphonates exhibit activity against pathogenic E. coli, S. aureus, Bacillus, or K. pneumonia strains (Figure 1) [22][23][24][25].…”

Section: Chemistrymentioning

confidence: 99%

Enzymatic Synthesis of a Novel Coumarin Aminophosphonates: Antibacterial Effects and Oxidative Stress Modulation on Selected E. coli Strains

Koszelewski

Kowalczyk

Brodzka

et al. 2023

IJMS

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The objective of the present study was to evaluate the synergistic effect of two important pharmacophores, coumarin and α-amino dimethyl phosphonate moieties, on antimicrobial activity toward selected LPS-varied E. coli strains. Studied antimicrobial agents were prepared via a Kabachnik–Fields reaction promoted by lipases. The products were provided with an excellent yield (up to 92%) under mild, solvent- and metal-free conditions. A preliminary exploration of coumarin α-amino dimethyl phosphonate analogs as novel antimicrobial agents was carried out to determine the basic features of the structure responsible for the observed biological activity. The structure–activity relationship revealed that an inhibitory activity of the synthesized compounds is strongly related to the type of the substituents located in the phenyl ring. The collected data demonstrated that coumarin-based α-aminophosphonates can be potential antimicrobial drug candidates, which is particularly crucial due to the constantly increasing resistance of bacteria to commonly used antibiotics.

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Section: Chemistrymentioning

confidence: 99%

Enzymatic Synthesis of a Novel Coumarin Aminophosphonates: Antibacterial Effects and Oxidative Stress Modulation on Selected E. coli Strains

Koszelewski

Kowalczyk

Brodzka

et al. 2023

IJMS

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“…44 Four different aldehydes were utilized in the synthesis process, along with the following amine; 4-(4-chlorophenyl)thiazol-2-amine (Scheme 1). Some techniques (IR, 1 H-NMR, 13 C-NMR, 31 P-NMR and Mass spectrometry) were used to interpret and investigate the chemical structures of the prepared a-aminophosphonate molecules (5)(6)(7)(8).…”

Section: Chemistry Of the Synthesized A-aminophosphonate Compundsmentioning

confidence: 99%

“…3,4 Amongst many others, a-aminophosphonate compounds were marked as potent pharmacophores from a drug-design perspective and showed promising biological activity against microbes and exhibited negligible toxicity toward mammalian cells. [5][6][7][8] The dressing materials should have characteristic features such as being biocompatible, biodegradable, easily produced and able to successfully restore their activity until reaching the target sites. Moreover, they should maintain a moist environment around the wound to enhance healing, 9 enable continuous wound site monitoring, allow the exchange of gases, and prevent subsequent infection of the wound and they should have a wide range spectrum of antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

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Self-crosslinked polyvinyl alcohol/cellulose nanofibril cryogels loaded with synthesized aminophosphonates as antimicrobial wound dressings

Elsherbiny¹,

Abdelgawad²,

Hemdan³

et al. 2023

J. Mater. Chem. B

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“…Other WD materials were developed based on cellulose acetate [ 85 , 86 , 87 , 88 ], hydroxyethyl cellulose [ 89 ], ethyl cellulose [ 90 ], hydroxypropyl methylcellulose [ 91 ], or cellulose micro/nanocrystals [ 78 , 92 ] (references are of this year). An interesting approach in developing vegetable patches was reported by Buonvino et al, who used the Lupinus albus L. hull, a vegetal waste, as raw material for the development of a novel active bioplastic, to be used as WD material or a cellular scaffold, benefiting from both cellulosic and phytochemical content of the hulls [ 93 ].…”

Section: Natural Products From Plants Used In Medical Devicesmentioning

confidence: 99%

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Isopencu,

Covaliu-Mierlă,

Deleanu

2023

Plants

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Transdermal delivery devices and wound dressing materials are constantly improved and upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, and cost effectiveness. Therefore, researchers in the field have shown an increasing interest in using natural compounds as constituents for such systems. Plants, as an important source of so-called “natural products” with an enormous variety and structural diversity that still exceeds the capacity of present-day sciences to define or even discover them, have been part of medicine since ancient times. However, their benefits are just at the beginning of being fully exploited in modern dermal and transdermal delivery systems. Thus, plant-based primary compounds, with or without biological activity, contained in gums and mucilages, traditionally used as gelling and texturing agents in the food industry, are now being explored as valuable and cost-effective natural components in the biomedical field. Their biodegradability, biocompatibility, and non-toxicity compensate for local availability and compositional variations. Also, secondary metabolites, classified based on their chemical structure, are being intensively investigated for their wide pharmacological and toxicological effects. Their impact on medicine is highlighted in detail through the most recent reported studies. Innovative isolation and purification techniques, new drug delivery devices and systems, and advanced evaluation procedures are presented.

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Thermoresponsive nanofibers loaded with antimicrobial α-aminophosphonate-o/w emulsion supported by cellulose nanocrystals for smart wound care patches

Cited by 13 publications

References 63 publications

Enzymatic Synthesis of a Novel Coumarin Aminophosphonates: Antibacterial Effects and Oxidative Stress Modulation on Selected E. coli Strains

Enzymatic Synthesis of a Novel Coumarin Aminophosphonates: Antibacterial Effects and Oxidative Stress Modulation on Selected E. coli Strains

Self-crosslinked polyvinyl alcohol/cellulose nanofibril cryogels loaded with synthesized aminophosphonates as antimicrobial wound dressings

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

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