Thermoresponsive mesoporous silica nanoparticles as a carrier for skin delivery of quercetin

Ugazio, Elena; Gastaldi, Lucia; Brunella, Valentina Giovanna; Scalarone, Dominique Maria; Jadhav, Sushilkumar A.; Oliaro‐Bosso, Simonetta; Zonari, Daniele; Berlier, Gloria; Miletto, Ivana; Sapino, Simona

doi:10.1016/j.ijpharm.2016.07.024

Cited by 87 publications

(53 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Target molecules allow the MSNs to reach the tumor tissue only through a molecular recognition mechanism. Then, once in the internal tissue, the stimuliresponsive capping agent [5,34] permits the release of the drug as a response to internal (change of pH [42][43][44][45], temperature [46][47][48], redox reactions [40,[49][50][51][52]) or external (irradiation with light [53][54][55], magnetic field [55][56][57]) stimuli.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

Nairi¹,

Magnolia²,

Piludu³

et al. 2018

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Mesoporous silica nanoparticles (MSNs) were functionalized with amino groups (MSN-NH) and then with hyaluronic acid, a biocompatible biopolymer which can be recognized by CD44 receptors in tumor cells, to obtain a targeting drug delivery system. To this purpose, three hyaluronic acid samples differing for the molecular weight, namely HA (8-15 kDa), HA (30-50 kDa) and HA (90-130 kDa), were used. The MSN-HA, MSN-HA, and MSN-HA materials were characterized through zeta potential and dynamic light scattering measurements at pH = 7.4 and T = 37 °C to simulate physiological conditions. While zeta potential showed an increasing negative value with the increase of the HA chain length, an anomalous value of the hydrodynamic diameter was observed for MSN-HA, which was smaller than that of MSN-HA and MSN-HA samples. The cellular uptake of MSN-HA samples on HeLa cells at 37 °C was studied by optical and electron microscopy. HA chain length affected significantly the cellular uptake that occurred at a higher extent for MSN-NH and MSN-HA than for MSN-HA and MSN-HA samples. Cellular uptake experiments carried out at 4 °C showed that the internalization process was inhibited for MSN-HA samples but not for MSN-NH. This suggests the occurrence of two different mechanisms of internalization. For MSN-NH the uptake is mainly driven by the attractive electrostatic interaction with membrane phospholipids, while MSN-HA internalization involves CD44 receptors overexpressed in HeLa cells.

show abstract

Section: Introductionmentioning

confidence: 99%

Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

Nairi¹,

Magnolia²,

Piludu³

et al. 2018

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

show abstract

“…With these backgrounds, the main goals of new skin drug delivery systems are improving drug biopharmaceutics and pharmacokinetics and obtaining a targeted drug delivery, without harming the protective function of the skin . Their role is mainly based on an interaction with the skin appendages and skin lipids leading to a facilitated release, a sustained release caused by drug depot and/or stimuli‐induced release, as well as the use of microneedles to penetrate the skin barrier, which is another in‐vogue technique . In the last years, inorganic nanoparticles have achieved important success in diverse technical fields as manufacturing and materials, environment, energy, electronics and what is more interesant for us, in the medical field.…”

Section: Figurementioning

confidence: 99%

“….In terms of skin‐directed therapies numerous scientific works have been published that deals with MSNs‐based nanosystems. Ugazio and coworkers have designed a thermoresponsive MSNs‐quercetin system providing controlled release of this antioxidant depending on the temperature conditions of the application place as well as a protective effect of the antioxidant molecules. Besides, it was proved that MSNs act not only as efficient topical nanocarriers but also show interesting properties to increase the stability of delicate antioxidant molecules such as derivatives of flavonoids like quercetin and of the vitamin E, trolox.…”

Section: Figurementioning

confidence: 99%

Advanced Inorganic Nanosystems for Skin Drug Delivery

Carazo

Borrego-Sánchez

García‐Villén

et al. 2018

The Chemical Record

View full text Add to dashboard Cite

On/into/through the skin drug delivery represents an attractive alternative for the oral route, providing local and/or systemic drug delivery. Due to its complex and well-organised structure, most of the drugs show difficulties to penetrate the human skin. Therefore, enormous efforts have been invested to develop intelligent drug delivery systems overcoming the skin barrier with particular emphasis on increasing therapeutic activity and minimizing undesirable side-effects. Most of these strategies require the use of singular materials with new properties. In particular, and on the basis of their inherent properties, including biocompatibility, biodegradability and relative low-cost, inorganic nanoparticles are ideal candidates for the development of skin drug delivery systems. This review provides an updated and comprehensive overview of the state of the art in the trends towards skin drug delivery with a particular focus in the attractive alternative offered by inorganic-based nanosystems.

show abstract

“…Thermoresponsive copolymer-grafted SBA-15 porous silica particles for temperature-triggered topical delivery systems thermosensitive porous materials useful in temperature-triggered drug delivery [11,12]. The porous particles in such DDS act as reservoirs for various molecules and the thermoresponsive polymer, through its typical coil-to-globule transition at its LCST, applies a pore opening and closing mechanism to the porous particles [13,14].…”

mentioning

confidence: 99%

Thermoresponsive copolymer-grafted SBA-15 porous silica particles for temperature-triggered topical delivery systems

Jadhav¹,

Scalarone²,

Brunella³

et al. 2017

Express Polym. Lett.

View full text Add to dashboard Cite

Abstract.A series of poly(N-isopropylacrylamide-co-acrylamide) thermoresponsive random copolymers with different molecular weights and composition were synthesized and characterized by attenuated total reflectance Fourier-transform infrared (ATR-FTIR), differential scanning calorimetry (DSC), size exclusion chromatography (SEC) and proton nuclear magnetic resonance (NMR) spectroscopy. The lower critical solution temperatures (LCST) of the copolymers were tuned by changing the mole ratios of monomers. Copolymer with highest molecular weight and LCST (41.2°C) was grafted on SBA-15 type mesoporous silica particles by a two-step polymer grafting procedure. Bare SBA-15 and the thermoresponsive copolymergrafted (hybrid) SBA-15 particles were fully characterized by scanning electron microscope (SEM), ATR-FTIR, thermogravimetric analysis (TGA) and Brunauer-Emmett-Teller (BET) analyses. The hybrid particles were tested for their efficiency as temperature-sensitive systems for dermal delivery of the antioxidant rutin (quercetin-3-O-rutinoside). Improved control over rutin release by hybrid particles was obtained which makes them attractive hybrid materials for drug delivery.

show abstract

Thermoresponsive mesoporous silica nanoparticles as a carrier for skin delivery of quercetin

Cited by 87 publications

References 29 publications

Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

Advanced Inorganic Nanosystems for Skin Drug Delivery

Thermoresponsive copolymer-grafted SBA-15 porous silica particles for temperature-triggered topical delivery systems

Contact Info

Product

Resources

About