Thermoresponsive in-situ gel containing hyaluronic acid and indomethacin for the treatment of corneal chemical burn

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

“…[39] Augusto de Castro et al addressed the issue of bioavailability by creating a poloxamer-based thermoresponsive gel consisting of both hyaluronic acid (HA) and indomethacin. [30] Essentially, at room temperature indomethacin is trapped inside the nanomicelle. The aggregation of nanomicelles occurs when the surrounding temperature increases.…”

“…-11 of 30 To this end, Xin et al presented the first ophthalmic drop for treating AMD via autophagy of aggregated protein and amyloid beta deposition. [32] The study also exemplified the first formulation to include (3β, 25R)-spirost-5-en-3-ol (Dio), a natural, amphiphilic molecule capable of downregulating VEGF expression and inhibiting amyloid-beta deposition.…”

“…-17 of 30 in hydrogel contact lenses for timolol delivery remains limited. Both pSB and pVP are biocompatible polymers that possess several unique properties of their own.…”

“…Such transmission could be achieved in two ways: (1) continuous reinfection and replication of neighboring cells that occurs throughout the nasolacrimal duct and (2) replication-independent travel of the virus that is assisted by ciliary cells of the nasolacrimal duct. Copyright 2022,[53] with permission from Springer Nature.12 of30…”

Effect of indomethacin on the electrical conductance and electrochemical voltammetry of copper chloride in methanol, ethanol, and their binary mixture with water

“…The peak potentials can provide insights into the thermodynamics and kinetics of these processes. In the presence of ligand, the cyclic voltammogram of metal ions may exhibit changes compared to its behavior in the absence of ligand [ [16] , [17] , [18] , [19] ].…”