Thermoresponsive hydrogels physically crosslinked with magnetically modified LAPONITE® nanoparticles

Goncharuk, E.V.; Samchenko, Yu. M.; Kernosenko, L.; Korotych, Olena; Poltoratska, Tetiana; Пасмурцева, Н.; Oranska, O.I.; Sternik, Dariusz; Mamyshev, Igor E.

doi:10.1039/d0sm00929f

Cited by 21 publications

(17 citation statements)

References 67 publications

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“…The LAP XRD pattern exhibited crystalline peaks at 2θ=16.90°, 29.63°, 32.36°, 39.73°, and 45.10°, respectively, which were similarly reported in previous researches [26]. After mixing LAP within CA/SA hydrogel matrix and crosslinking process, the sharp peaks in the XRD pattern related to LAP slightly shifted to 2θ=27.40°, 28.82°, 30.97°, and 45.34°, respectively, due to the formation of hydrogen bonds between LAP within CA/SA hydrogel matrix [22,27].…”

Section: Resultssupporting

confidence: 85%

An injectable cellulose acetate/sodium alginate hydrogels-loaded laponite microsphere as a potential wound healing in nursing care in perioperative period

Wang¹,

Yang

Zhao

2022

Mater. Res. Express

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The aim of this study was developed by a simple method including solution mixing of cellulose acetate/sodium alginate containing laponite (CA/SA-LAP) hydrogel composites with flexible mechanical, physical, and biological properties for wound healing application. The surface properties of the as-prepared CA/SA hydrogel and CA/SA-LAP hydrogel composites were characterized by Fourier transform infrared spectroscopy (FT-IR) and X-Ray Diffraction (XRD). The influence of LAP content (0.1, 0.2, 0.5 wt%), the swelling ratio (171.0 ± 7.0, 143.0 ± 4.0, and 96.6 ± 2.5), degradation rate (65.7 ± 4.0%, 49.0 ± 5.5%, and 19.4 ± 1.4%), mechanical properties elongation at break from 68.3 ± 6.0% to 148.3 ± 5.6%, and the morphology of the CA/SA-LAP was investigated. By increasing the LAP concentration with an average pore size diameter decreased from 300  μm to 225  μm, 150  μm, and 75 μm. The as-prepared CA/SA-LAP dressing has designated good antimicrobial activity against Staphylococcus aureus and Escherichia coli bacteria at 95.9 ± 4.0% and 98.4 ± 1.5% for 24 h and 92.3 ± 4.5% and 96.4 ± 3.5% for 48 h. Furthermore, CA/SA-LAP revealed admirable biocompatibility against human osteosarcoma cell line MG-63. Noticeably, the MTT assay demonstrated that fibroblast proliferation significantly enhanced on 0.5 wt.% LAP in CA/SA-LAP compared to CS/SA hydrogel at 92.6 ± 4.2% and 96.4 ± 3.5% for 24 and 48 h. Systematic in vivo research of the CA/SA-LAP was conducted in the rat bone defect model. The in vivo results proved that the CA/SA-loaded LAP significantly promoted bone healing in rat defects, compared to the CA/SA hydrogels. These results demonstrated the great potential of CA/SA-loaded LAP in wound healing material in nursing care application.

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Section: Resultssupporting

confidence: 85%

An injectable cellulose acetate/sodium alginate hydrogels-loaded laponite microsphere as a potential wound healing in nursing care in perioperative period

Wang¹,

Yang

Zhao

2022

Mater. Res. Express

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“…Various modifications of the surface structure of cross-linking nanoplatelets can significantly affect the properties of hydrogels. Particularly, a similar shift of T d toward lower temperatures was observed in the physically cross-linked hydrogels based on polyNIPAAm and magnetically decorated Lap particles . Based on these findings, the Lap/aLap nanoparticles can represent useful candidates for the preparation of physically cross-linked hydrogels with tuned swelling and deswelling temperatures for the controlled drug delivery applications.…”

Section: Discussionsupporting

confidence: 66%

“…Particularly, a similar shift of T d toward lower temperatures was observed in the physically cross-linked hydrogels based on polyNIPAAm and magnetically decorated Lap particles. 13 Based on these findings, the Lap/aLap nanoparticles can represent useful candidates for the preparation of physically cross-linked hydrogels with tuned swelling and deswelling temperatures for the controlled drug delivery applications. Therefore, more detailed studies of the mechanisms of cross-linking and the structure of Lap-based hydrogel materials are crucial and necessary in the future.…”

Section: ■ Conclusionmentioning

confidence: 97%

“…Modification of Lap particles also resulted in changing of a three-dimensional spatial network in hydrogels. For example, the use of magnetically modified Lap as a physical cross-linking agent allowed us to synthesize magnetic thermosensitive hydrogel nanocomposites with improved mechanical properties and swelling ability, controllable temperature-induced drug release, and demonstrated promise as a nanoplatform for targeted contactless drug delivery under application of weak magnetic fields . Biocompatible and magneto-responsive Lap-based hydrogels with tunable properties were prepared.…”

Section: Introductionmentioning

confidence: 99%

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Cross-Linked Hydrogels Based on PolyNIPAAm and Acid-Activated Laponite RD: Swelling and Tunable Thermosensitivity

et al. 2022

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The effects of acid activation of Laponite RD (Lap) on the structure and properties of activated Lap nanoparticles (aLap) and the properties of polyNIPAA m hydrogels physically cross-linked by aLap have been studied. The acid activation of Lap by the sulfuric acid was done using the concentration of sulfuric acid within the interval C a = 0.525−14.58% for 10 h. For slightly activated samples (C a ≤ 1.25 wt %), the significant increase of the specific surface area (by ≈1.56 times) was accompanied with a significant decrease in both the values of the specific heat of immersion in water and n-decane. However, the hydrophilic properties of all samples S 0 −S 5 were still observed. Thermogravimetric analysis (TGA) and differential thermal analysis (DTA) data, Fourier transform infrared (FTIR) spectra, and X-ray diffraction (XRD) patterns demonstrated that the acid activation resulted in the destruction of the crystal lattice of Lap, leaching of magnesium and lithium, and formation of the amorphous phases. Moreover, the acid activation significantly affected aggregation and negative surface charges of the aLap faces in aqueous suspension. The effects of aLap on the swelling properties and cooperativity in the phase transitions of polyNIPAA m hydrogels cross-linked by aLap are also discussed. It was demonstrated that an increase in C a resulted in a significant increase in the equilibrium degree of swelling of the hydrogels and a decrease in the hydrogel phase-transition temperature from the swollen phase to the shrunken phase.

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“…This process leads to an increase in hydrogel volume but its geometric shape remains unchanged. The so-called "smart hydrogels" are spatially cross-linked hydrophilic polymers with a three-dimensional structure capable of responding to various external physical factors, including minor changes in pH, temperature, ionic strength, etc., by changing the swelling degree, volume, sorption and diffusion characteristics (Schmaljohann 2006; Kocak et al 2016;Samchenko et al 2018;Goncharuk et al 2020). They can be synthesized in different consistency and arbitrary shape, particularly in the form of granules of controlled sizes.…”

Section: Introductionmentioning

confidence: 99%

Polyacrylamide Hydrogels With Amber for Plants Micropropagation

Kernosenko

Samchenko

Goncharuk

et al. 2022

Preprint

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The in vitro cultivation and reproduction of plants is one of the most modern and promising methods of cultivating valuable plants using artificial nutrient media. In this work, a new solid nutrient media for plant micropropagation based on highly dispersed polyacrylamide hydrogel (PAAG) with amber powder was synthesized and investigated. PAAG was synthesized by homophase radical polymerization with grounded amber addition. FTIR (Fourier transform infrared spectroscopy) and rheological studies were used to characterize structural properties of the materials. The synthesized hydrogel showed physicochemical and rheological parameters similar to the standard agar media. The estimation of acute toxicity of PAAG-amber was performed based on the influence of washing waters on the viability of the selected plant seeds (pea and chickpea) and animal (Daphnia magna). It proved its biosafety after four washes. The impact on plant rooting was studied using multiplication of Cannabis sativa on synthesized PAAG-amber saturated with Murashige-Skoog (MS) medium and compared with agar gel with MS. Developed substrate stimulated the rooting of the plants up to more than 98% in comparison to standard agar medium (95%). Also, PAAG-amber nutrient medium markedly enhanced metric indicators of seedling: root length increased by 28%, stem length – by 26.7%, root weight – by 167%, stem weight – by 67%, root and stem length – by 27%, root and stem weight – by 50%. This means that the developed hydrogel significantly accelerates reproduction and allows obtaining a larger amount of plant material within a shorter period than the standard agar medium.

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Thermoresponsive hydrogels physically crosslinked with magnetically modified LAPONITE® nanoparticles

Abstract: Application of LAPONITE®/magnetite nanoparticles to physically crosslink poly(N-isopropylacrylamide) yields hierarchically structured hydrogel nanocomposites which can be used as magnetically controlled carriers with thermo-induced drug release.

Cited by 21 publications

References 67 publications

An injectable cellulose acetate/sodium alginate hydrogels-loaded laponite microsphere as a potential wound healing in nursing care in perioperative period

An injectable cellulose acetate/sodium alginate hydrogels-loaded laponite microsphere as a potential wound healing in nursing care in perioperative period

Cross-Linked Hydrogels Based on PolyNIPAAm and Acid-Activated Laponite RD: Swelling and Tunable Thermosensitivity

Polyacrylamide Hydrogels With Amber for Plants Micropropagation

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