Thermoresponsive Hydrogels and Their Biomedical Applications: Special Insight into Their Applications in Textile Based Transdermal Therapy

Chatterjee, Sudipta; Chiu, Patrick; Kan, Chi Wai

doi:10.3390/polym10050480

Cited by 133 publications

(115 citation statements)

References 206 publications

(274 reference statements)

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“…The combination of the algae-derived polysaccharide alginate and animal protein-derived gelatin has better mimicked the components of ECMs around human cells in soft organs [51][52][53][54]. Suitable A-G-IPNs with optimized polymer concentrations have been achieved through different alginate and gelatin compositions and crosslinking sequences.…”

Section: Discussionmentioning

confidence: 99%

An Interpenetrating Alginate/Gelatin Network for Three-Dimensional (3D) Cell Cultures and Organ Bioprinting

et al. 2020

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Crosslinking is an effective way to improve the physiochemical and biochemical properties of hydrogels. In this study, we describe an interpenetrating polymer network (IPN) of alginate/gelatin hydrogels (i.e., A-G-IPN) in which cells can be encapsulated for in vitro three-dimensional (3D) cultures and organ bioprinting. A double crosslinking model, i.e., using Ca 2+ to crosslink alginate molecules and transglutaminase (TG) to crosslink gelatin molecules, is exploited to improve the physiochemical, such as water holding capacity, hardness and structural integrity, and biochemical properties, such as cytocompatibility, of the alginate/gelatin hydrogels. For the sake of convenience, the individual ionic (i.e., only treatment with Ca 2+ ) or enzymatic (i.e., only treatment with TG) crosslinked alginate/gelatin hydrogels are referred as alginate-semi-IPN (i.e., A-semi-IPN) or gelatin-semi-IPN (i.e., G-semi-IPN), respectively. Tunable physiochemical and biochemical properties of the hydrogels have been obtained by changing the crosslinking sequences and polymer concentrations. Cytocompatibilities of the obtained hydrogels are evaluated through in vitro 3D cell cultures and bioprinting. The double crosslinked A-G-IPN hydrogel is a promising candidate for a wide range of biomedical applications, including bioartificial organ manufacturing, high-throughput drug screening, and pathological mechanism analyses.

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Section: Discussionmentioning

confidence: 99%

An Interpenetrating Alginate/Gelatin Network for Three-Dimensional (3D) Cell Cultures and Organ Bioprinting

et al. 2020

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“…Thermoresponsive hydrogels are made from a wide variety of natural and synthetic polymers, and some thermoresponsive hydrogels forming polymers find a lot of interests as these hydrogels have excellent biomedical applications especially for developing drug delivery systems used in cancer therapy, transdermal drug therapy, and oral drug delivery [25,35,51,52]. The thermoresponsive polymers widely used in developing drug delivery systems are poly(N-isopropylacrylamide) (pNIPAAm); pluronics® or poloxamers mainly pluronic F127 (PF127), polyoxazoline, and poly(organophosphazenes); and some natural polymers having thermoresponsive properties are gelatin/collagen, cellulose, chitosan, xyloglucan, starch, xanthan gum, carrageenans, hyaluronic acid, dextran, poly(γ-glutamate), and elastin and elastin like polypeptide/oligopeptide [53][54][55]. The most commonly used polymers to develop pH-responsive behavior in hydrogels include either acidic groups (carboxylic) or basic groups (amino), and the monomers used in pH-responsive polymers are acrylic acid, acrylamide, methacrylic acid, dimethylaminoethyl methacrylate, diethylaminoethyl methacrylate, and ethylene glycol [46,56].…”

Section: Introductionmentioning

confidence: 99%

“…Stimuli-responsive polymers are used as surface modifying systems of textile fabrics to enrich them with advanced functionalities and environmental responsiveness [61]. Thermoresponsive/pH-responsive or any other stimuli-responsive hydrogel present on textile fabric is capable of responding to changes in environmental conditions and giving comfort by actively balancing body temperature and moisture [53]. Stimuli-responsive (thermoresponsive) hydrogels are used as drug delivery systems for the controlled release of drugs from functionalized textiles applied for skin care [53,61].…”

Section: Introductionmentioning

confidence: 99%

“…Thermoresponsive/pH-responsive or any other stimuli-responsive hydrogel present on textile fabric is capable of responding to changes in environmental conditions and giving comfort by actively balancing body temperature and moisture [53]. Stimuli-responsive (thermoresponsive) hydrogels are used as drug delivery systems for the controlled release of drugs from functionalized textiles applied for skin care [53,61]. Thereby, drug delivery systems from hydrogels of stimuli-responsive polymers are being developed for textile-based transdermal therapy [61].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Stimuli-Responsive Hydrogels: An Interdisciplinary Overview

Chatterjee¹,

Chiu²

2019

Hydrogels - Smart Materials for Biomedical Applications

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Stimuli-responsive hydrogels formed by various natural and synthetic polymers are capable of showing distinctive changes in their properties with external stimuli like temperature, pH, light, ionic changes, and redox potential. Some hydrogels are developed to exhibit dual responsiveness with external stimuli such as pH and temperature. The stimuli-responsive hydrogels find a wide variety of biomedical applications including drug delivery, gene delivery, and tissue regeneration. The advanced functionalities can be imparted to textile materials by integrating stimuli-responsive hydrogels into them and stimuli-responsive hydrogels including thermoresponsive, pH-responsive, and dual-responsive improve moisture and water retention property, environmental responsiveness, esthetic appeal, display, and comfort of textiles. Stimuli-responsive hydrogels loaded with various kinds of drugs are applied for textile-based transdermal therapy as these hydrogels as drug carriers show controlled and sustained drug release. In this chapter, drug delivery and textile applications of thermoresponsive, pH-responsive, and dual-responsive (pH and temperature) hydrogels are discussed and analyzed.

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“…Hydrogels are three dimensional, hydrophilic networks of cross-linked polymers with a high capacity to absorb and retain water and other biological fluids (1)(2)(3)(4)(5)(6). They can be made from virtually any water-soluble polymer, and can be formulated in a number of different physical forms including: microparticles; nanoparticles; and films (1)(2)(3)(4)(5)(6). Crosslinking between polymeric chains can be achieved by chemical bonds (chemical hydrogels) (2,7) or by non-covalent interactions (physical hydrogels) (7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Poly(methyl vinyl ether-co-maleic acid) Hydrogels Containing Cyclodextrins and Tween 85 for Potential Application as Hydrophobic Drug Delivery Systems

et al. 2019

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Hydrogels have been extensively investigated as a platform for drug delivery. However, their use for the delivery of hydrophobic drugs has been limited by their incompatibility with hydrophobic drug molecules. The chemical modification of the structure of the hydrogels to include hydrophobic moieties has been proven to be a good alternative to increase the stability and solubility of hydrophobic drugs in the polymer matrix of the hydrogel. The inclusion of hydroxypropyl-β-cyclodextrins (HPBCD) and Tween ® 85 (T85) within hydrogel matrices has the potential to improve hydrophobic drug loading and release. HPBCD have the ability to host hydrophobic drug molecules in their cone-like structure, forming inclusion complexes through host-guest interactions. On the other hand, T85 is an amphiphilic molecule and, consequently, has the potential to increase hydrophilic drug loading within the hydrogels. In the present work, a new type of hydrogel made from poly(methyl vinyl ether-co-maleic acid) (GAN) and poly(ethylene glycol) (PEG) containing T85 and HPBCD was synthesized for hydrophobic drug release. Hydrogels were based on GAN crosslinked (PEG) and HPBCD and/or T85 via an esterification reaction in the solid state (solvent free). The synthesised hydrogels were characterised using Fourier transform infrared (FTIR) spectroscopy, swelling studies and contact angle measurements. The hydrogels showed swellings ranging from 140 to 180%. The inclusion of T85 in the hydrogels improved the wettability of the materials. On the other hand, the inclusion of HPBCD within the hydrogels decreased the wettability as the contact angle between the hydrogels and water increased with the HPBCD content. Finally, the materials were loaded with an ophthalmic drug, dexamethasone (DX). HPBC-containing hydrogels showed a higher DX uptake and, consequently, they showed a higher capacity of DX release. On the other hand, T85 containing hydrogels did not show any improvement over the hydrogels containing only GAN and PEG. The hydrogels were able to provide sustained DX release over periods of 6 hours.

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Thermoresponsive Hydrogels and Their Biomedical Applications: Special Insight into Their Applications in Textile Based Transdermal Therapy

Cited by 133 publications

References 206 publications

An Interpenetrating Alginate/Gelatin Network for Three-Dimensional (3D) Cell Cultures and Organ Bioprinting

An Interpenetrating Alginate/Gelatin Network for Three-Dimensional (3D) Cell Cultures and Organ Bioprinting

Stimuli-Responsive Hydrogels: An Interdisciplinary Overview

Poly(methyl vinyl ether-co-maleic acid) Hydrogels Containing Cyclodextrins and Tween 85 for Potential Application as Hydrophobic Drug Delivery Systems

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