Thermoresponsive dynamic BAB block copolymer networks synthesized by aqueous PISA in one-pot

Biais, Pauline; Engel, M.; Colombani, Olivier; Nicolai, Taco; Stoffelbach, François; Rieger, Jutta

doi:10.1039/d0py01424a

Cited by 14 publications

(19 citation statements)

References 48 publications

(75 reference statements)

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“…216 In addition to the work from Zhang's group, the Rieger group also studied various loop-stabilized BAB particles by PISA (Flower PISA), and they found loop solvophilic chains exhibit different stabilizing behaviors, the bridges between the B blocks lead to the formation of gel-like dynamic polymer network. 217–219…”

Section: Controlled and High-order Morphologies By Pisamentioning

confidence: 99%

RAFT-mediated polymerization-induced self-assembly (RAFT-PISA): current status and future directions

2022

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Section: Controlled and High-order Morphologies By Pisamentioning

confidence: 99%

RAFT-mediated polymerization-induced self-assembly (RAFT-PISA): current status and future directions

2022

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“…In the case of an ABA block copolymer, hydrogel formation was observed above 37 °C. The concept was expanded later with various other combinations of polymer blocks, e.g., PNIPAM‐ b ‐poly( N , N ‐dimethylacrylamide)‐ b ‐PNIPAM (PNIPAM‐ b ‐PDMA‐ b ‐PNIPAM), [ 54,55 ] poly(diacetone acrylamide‐ co ‐DMA)‐ b ‐PDMA‐ b ‐poly(diacetone acrylamide‐ co ‐DMA), [ 56 ] PNIPAM‐ b ‐PEG‐ b ‐PNIPAM [ 57 ] or poly(ethoxydi(ethylene glycol) acrylate‐ co ‐acrylic acid)‐ b ‐PEG‐ b ‐poly(ethoxydi(ethylene glycol) acrylate‐ co ‐acrylic acid). [ 58 ] The concept of thermogelation was further expanded toward ABA block copolymers formed from protein central blocks and PNIPAM outer blocks for shear‐thinning hydrogels by Olsen and co‐workers.…”

Section: Types Of Multicompartment Hydrogelsmentioning

confidence: 99%

Multicompartment Hydrogels

Schmidt

2022

Macromol. Rapid Commun.

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Hydrogels belong to the most promising materials in polymer and materials science at the moment. As they feature soft and tissue-like character as well as high water-content, a broad range of applications are addressed with hydrogels, e.g., tissue engineering and wound dressings but also soft robotics, drug delivery, actuators, and catalysis. Ways to tailor hydrogel properties are crosslinking mechanisms, hydrogel shape, and reinforcement, but new features can be introduced by variation of hydrogel composition as well, e.g., via monomer choice, functionalization or compartmentalization. In particular, multicompartment hydrogels drive progress toward complex and highly functional soft materials. In the present review the latest developments in multicompartment hydrogels are highlighted with a focus on three types of compartments; micellar/vesicular, droplets, and multilayers including various subcategories. Furthermore, several morphologies of compartmentalized hydrogels and applications of multicompartment hydrogels will be discussed as well. Finally, an outlook toward future developments of the field will be given. The further development of multicompartment hydrogels is highly relevant for a broad range of applications and will have a significant impact on biomedicine and organic devices.

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“…This is because the structure-directing block is only weakly hydrophobic in this case; hence, subtle changes in its (partial) degree of hydration on either heating or cooling can induce morphological transitions. 12 , 46 , 51 , 52 , 60 − 62 There are many examples of RAFT aqueous dispersion polymerization reported in the literature. 12 , 13 , 15 , 37 , 39 , 42 , 43 , 47 , 49 − 51 , 57 − 59 , 63 − 75 However, the prototypical—and certainly most widely explored—formulation is based on the RAFT aqueous dispersion polymerization of 2-hydroxypropyl methacrylate (HPMA).…”

Section: Introductionmentioning

confidence: 99%

Reversible Addition-Fragmentation Chain Transfer Aqueous Dispersion Polymerization of 4-Hydroxybutyl Acrylate Produces Highly Thermoresponsive Diblock Copolymer Nano-Objects

2022

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The reversible addition-fragmentation chain transfer (RAFT) aqueous dispersion polymerization of 2-hydroxypropyl methacrylate (HPMA) using a poly(glycerol monomethacrylate) (PGMA) precursor is an important prototypical example of polymerization-induced self-assembly. 4-Hydroxybutyl acrylate (HBA) is a structural isomer of HPMA, but the former monomer exhibits appreciably higher aqueous solubility. For the two corresponding homopolymers, PHBA is more weakly hydrophobic than PHPMA. Moreover, PHBA has a significantly lower glass transition temperature ( T g ) so it exhibits much higher chain mobility than PHPMA at around ambient temperature. In view of these striking differences, we have examined the RAFT aqueous dispersion polymerization of HBA using a PGMA precursor with the aim of producing a series of PGMA 57–300 -PHBA 100–1580 diblock copolymer nano-objects by systematic variation of the mean degree of polymerization of each block. A pseudo-phase diagram is constructed using transmission electron microscopy to assign the copolymer morphology after employing glutaraldehyde to cross-link the PHBA chains and hence prevent film formation during grid preparation. The thermoresponsive character of the as-synthesized linear nano-objects is explored using dynamic light scattering and temperature-dependent rheological measurements. Comparison with the analogous PGMA x -PHPMA y formulation is made where appropriate. In particular, we demonstrate that replacing the structure-directing PHPMA block with PHBA leads to significantly greater thermoresponsive behavior over a much wider range of diblock copolymer compositions. Given that PGMA-PHPMA worm gels can induce stasis in human stem cells (see Canton et al. , ACS Central Science , 2016, 2 , 65–74), our findings are likely to have implications for the design of next-generation PGMA-PHBA worm gels for cell biology applications.

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Thermoresponsive dynamic BAB block copolymer networks synthesized by aqueous PISA in one-pot

Abstract: The incorporation of neutral hydrophilic monomer units in the hydrophobic B blocks of BAB copolymers produces transient networks exhibiting a thermoresponsive behavior with a maximum of viscosity in water.

Cited by 14 publications

References 48 publications

RAFT-mediated polymerization-induced self-assembly (RAFT-PISA): current status and future directions

RAFT-mediated polymerization-induced self-assembly (RAFT-PISA): current status and future directions

Multicompartment Hydrogels

Reversible Addition-Fragmentation Chain Transfer Aqueous Dispersion Polymerization of 4-Hydroxybutyl Acrylate Produces Highly Thermoresponsive Diblock Copolymer Nano-Objects

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