Thermoresponsive Core-cross-linked Nanoparticles from HA-b-ELP Diblock Copolymers
Manon Levêque,
Sébastien Lecommandoux,
Elisabeth Garanger
Abstract:Stabilization against the dilution-dependent disassembly of self-assembled nanoparticles is a requirement for in vivo application. Herein, we propose a simple and biocompatible cross-linking reaction for the stabilization of a series of nanoparticles formed by the self-assembly of amphiphilic HA-b-ELP block copolymers, through the alkylation of methionine residues from the ELP block with diglycidyl ether compounds. The core-cross-linked nanoparticles retain their colloidal properties, with a spherical core−she… Show more
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