2022
DOI: 10.1021/acs.biomac.1c01368
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Thermoresponsive and Self-Healing Hydrogel Based on Chitosan Derivatives and Polyoxometalate as an Antibacterial Coating

Abstract: Hospital-acquired infections are a serious threat to the recovery of patients. To prevent such infections, an antibacterial coating is an effective method to eliminate bacterial colonization on healthcare-related surfaces. Herein, we report an antibacterial hydrogel composed of silver-containing polyoxometalate (AgP5W30 POM) and carboxymethyl chitosan (CMC). The silver ion is encapsulated inside the POM cage and demonstrates long-lasting bacteriostasis after repeated exposure to both Gram-positive and Gram-neg… Show more

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Cited by 30 publications
(25 citation statements)
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“…[125] As a classical matter, silver ion is enwrapped into a POM to form [AgP 5 W 30 O 110 ] 14− (AgP 5 W 30 ), which is further used to combine with chitosan derivatives, generating hydrogels. [126] The chemical substitution of chitosan has obvious influence to the gelation ability, and hydrogel comprising of CMC and AgP 5 W 30 possesses the best mechanical performance, which can be modulated by pH or the concentration of the solution. As shown in Figure 16a, the antibacterial behaviors of the AgP 5 W 30 -CMC hydrogel are evaluated on an agar disk.…”
Section: Antibacterial Coatingmentioning
confidence: 99%
See 1 more Smart Citation
“…[125] As a classical matter, silver ion is enwrapped into a POM to form [AgP 5 W 30 O 110 ] 14− (AgP 5 W 30 ), which is further used to combine with chitosan derivatives, generating hydrogels. [126] The chemical substitution of chitosan has obvious influence to the gelation ability, and hydrogel comprising of CMC and AgP 5 W 30 possesses the best mechanical performance, which can be modulated by pH or the concentration of the solution. As shown in Figure 16a, the antibacterial behaviors of the AgP 5 W 30 -CMC hydrogel are evaluated on an agar disk.…”
Section: Antibacterial Coatingmentioning
confidence: 99%
“…SEM images of S.aureus e) before and f) after its co-cultivation with AgP 5 W 30 -CMC hydrogel. Reproduced with permission [126]. Copyright 2022, The American Chemical Society.…”
mentioning
confidence: 99%
“…In the infection process of HAIs, bacteria first attach to the surfaces of the materials in a nonspecific binding manner, continuously secrete the extracellular matrix, form bacterial biofilms on the surfaces, and then multiply. , Antibacterial agents such as antibiotics have been usually used to reduce and eliminate infections, but dense biofilms hindered the penetration of antibiotics, resulting in poor antibacterial effects . In addition, the abuse of antibiotics has caused the emergence of dangerous drug-resistant bacteria, which further threaten human health.…”
Section: Introductionmentioning
confidence: 99%
“…Carboxymethyl chitosan (CCS) possesses good water solubility. It has a lot of amino, carboxyl, and hydroxyl groups that can provides a convenient condition for further modification. , In addition, the carboxymethyl chitosan film can achieve the controlled release of the loaded substance and has a certain antibacterial ability. , For all these advantages, carboxymethyl chitosan has been widely used as a carrier and medium in the preparation of antibacterial coatings on the surface of biomaterials. In this study, we established a positively charged surface by silane coupling on pTa scaffold, which had been alkali heated, and we further immersed the scaffold alternately in carboxymethyl chitosan solution and vancomycin (first-line medication for methicillin-resistant Staphylococcus aureus (MRSA) infection) solution with opposite charge.…”
Section: Introductionmentioning
confidence: 99%