Thermoresponsive and Conductive Chitosan-Polyurethane Biocompatible Thin Films with Potential Coating Application

Abstract

Conductive thin films have great potential for application in the biomedical field. Herein, we designed thermoresponsive and conductive thin films with hydrophilicity, strain sensing, and biocompatibility. The crosslinked dense thin films were synthesized and prepared through a Schiff base reaction and ionic interaction from dialdehyde polyurethane, N-carboxyethyl chitosan, and double-bonded chitosan grafted polypyrrole. The thin films were air-dried under room temperature. These thin films showed hydrophilicity and conductivity (above 2.50 mS/cm) as well as responsiveness to the deformation. The tensile break strength (9.72 MPa to 15.07 MPa) and tensile elongation (5.76% to 12.77%) of conductive thin films were enhanced by heating them from 25 °C to 50 °C. In addition, neural stem cells cultured on the conductive thin films showed cell clustering, proliferation, and differentiation. The application of the materials as a conductive surface coating was verified by different coating strategies. The conductive thin films are potential candidates for surface modification and biocompatible polymer coating.

Chitosan‐based nanocomposites for medical applications

“…Processing into a freestanding thin film is the easiest choice and affordable route to evaluate the physico-mechanical properties and biocompatibility of the designed nanocomposites. [42][43][44] Chitosan nanocomposite thin films can be fabricated using solution casting, melt mixing, and in-situ nanoparticle synthesis approaches. Solution casting is usually carried out using water, cell culture medium, and sometimes organic solvents.…”

“…Various existing methodologies have been adapted for processing of chitosan‐based nanocomposites into films, 34 fiber‐meshes, 35 hydrogels, 36–40 and 3D printed constructs 41 to mimic the 3D environment of tissues. Processing into a freestanding thin film is the easiest choice and affordable route to evaluate the physico‐mechanical properties and biocompatibility of the designed nanocomposites 42–44 . Chitosan nanocomposite thin films can be fabricated using solution casting, melt mixing, and in‐situ nanoparticle synthesis approaches.…”

Enhancement of Cell Behavior by the Polysaccharide Extract of Arthrospira and Potential Biomedical Applications

“…A conventional overlay coating method was initially attempted to decorate AdSP on the substrate dish, which was conducted by overlay coating and washing three times, followed by drying [ 33 ]. The outcome showed that a significant difference between the dish treated by the overlay coating method and the untreated non-adhesive dish did not exist, indicating that AdSP was not readily attached to the substrate by the regular casting.…”

“…AdSP was coated on the material surface based on a self-developed method inspired from the previous literature [ 33 ]. The surface of non-adherent polystyrene dish (diameter/height: 35/10 mm, Greiner Bio-One, Frickenhausen, Germany) was used as the pristine substrate.…”

Advances in Controlled Release Fertilizers: Cost‐Effective Coating Techniques and Smart Stimuli‐Responsive Hydrogels

“…Polyurethane is another polymer that can be engineered to manifest reversible changes in chemical and physical characteristics upon exposure to temperature variations. [87][88][89] One example of polyurethane used as a thermo-responsive coating material for CRF application is the study by Qiao et al, who employed polycaprolactone (PCL) with varying molecular weights (PCL500, PCL1000, PCL2000, and PCL3000) as raw materials to produce six types of polyurethane-based CRF coatings by reacting polyether polyol (PPG)/PCL blends with methylene diphenyl diisocyanate (MDI). Results demonstrated that PPG/PCL2000-based PUCF blends can copolymerize with MDI to generate a block copolymer with a two-phase structure (crystalline/amorphous).…”