Thermoresponsive and antibacterial two-dimensional polyglycerol-interlocked-polynipam for targeted drug delivery

Khosravani, Nasim; Ahmadi, Vahid; Kakanejadifard, Ali; Adeli, Mohsen

doi:10.1007/s40097-022-00514-0

Cited by 3 publications

(5 citation statements)

References 48 publications

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“…The physicochemical properties of these nanostructures and their large surface area with abundant accessible active sites make them attractive components for a wide range of applications encompassing electronic and optical devices, membranes, drug delivery systems, and multimodal contrast agents, among others [ 3 , 4 , 5 , 6 , 7 , 8 ]. NSHs can be made of organic (usually polymers and surfactants) or inorganic (e.g., Au, boron nitride (BN), graphene, and transition-metal dichalcogenides (TMDs) (MoS 2 , TaS 2 , WS 2 …)) materials [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. When NSHs are composed of a combination of both organic and inorganic materials, they are commonly known as “hybrid NSHs”.…”

Section: Introductionmentioning

confidence: 99%

“…These nanostructures present huge potential as chemical and biological sensing materials due to their physical and chemical properties, ease of functionalization, and flexibility. Moreover, when combined with appropriate polymers [ 15 , 16 , 17 , 18 , 19 ], NSHs acquire the capacity to respond to external stimulations such as temperature, light, or pH changes, thus undergoing a reversible shape transformation from 2D to 1D (one dimensional) materials, to form “nanoscrolls” (NSCs). NSCs present open tubular structures with tunable interlayer gaps between their walls.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, nanomaterials and nanostructures attract great interest for a wide range of applications linked to public health and safety. For example, smart and active nanomaterials can be easily applied to goods and objects used in our daily routines, providing alternatives to environment preservation and remediation, and bringing notable improvements in public health when used for antibacterial, self-cleaning, and self-healing ends [ 15 , 16 , 20 ]. In the specific case of nanomaterials applied to medicine (nanomedicine), this multidisciplinary field has captured the interest of researchers and engineers from different disciplines, with aims to provide solutions for early diagnosis and targeted therapy, toward personalized medicine ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, putting together multidisciplinary skills is likely to be the most effective shortcut to build the required knowledge and “know-how” toward “accessible personalized medicine”. In particular, advances in nanomaterial technology, merging nanomaterials with different properties, have created new paradigms for multifunctional nanostructures within a single platform [ 14 , 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Stimulus-Responsive Ultrathin Films for Bioapplications: A Concise Review

Benelmekki

Kim

2023

Molecules

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The term “nanosheets” has been coined recently to describe supported and free-standing “ultrathin film” materials, with thicknesses ranging from a single atomic layer to a few tens of nanometers. Owing to their physicochemical properties and their large surface area with abundant accessible active sites, nanosheets (NSHs) of inorganic materials such as Au, amorphous carbon, graphene, and boron nitride (BN) are considered ideal building blocks or scaffolds for a wide range of applications encompassing electronic and optical devices, membranes, drug delivery systems, and multimodal contrast agents, among others. A wide variety of synthetic methods are employed for the manufacturing of these NSHs, and they can be categorized into (1) top-down approaches involving exfoliation of layered materials, or (2) bottom-up approaches where crystal growth of nanocomposites takes place in a liquid or gas phase. Of note, polymer template liquid exfoliation (PTLE) methods are the most suitable as they lead to the fabrication of high-performance and stable hybrid NSHs and NSH composites with the appropriate quality, solubility, and properties. Moreover, PTLE methods allow for the production of stimulus-responsive NSHs, whose response is commonly driven by a favorable growth in the appropriate polymer chains onto one side of the NSHs, resulting in the ability of the NSHs to roll up to form nanoscrolls (NSCs), i.e., open tubular structures with tunable interlayer gaps between their walls. On the other hand, this review gives insight into the potential of the stimulus-responsive nanostructures for biosensing and controlled drug release systems, illustrating the last advances in the PTLE methods of synthesis of these nanostructures and their applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Stimulus-Responsive Ultrathin Films for Bioapplications: A Concise Review

Benelmekki

Kim

2023

Molecules

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“…Poly(N-isopropylacrylamide) (PNIPAAM) is a thermosensitive polymer with a lower critical solution temperature (LCST) of approximately 32 °C, which is below the physiological temperature of the human body. Its unique thermo-responsive properties allow its solution to transition from a sol state to a more viscous gel state by increasing the temperature to 37 °C [ 18 ], making it an ideal drug delivery vehicle. This temperature-triggered gelation ensures controlled drug release, targeted delivery to specific areas like tumor sites, and enhanced drug stability during transportation and storage.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Titanium Dioxide Nanoparticles—Poly(N-isopropylacrylamide) Hydrogel Prepared by Electron Beam Irradiation Inhibits the Proliferation and Migration of Oral Squamous Cell Carcinoma Cells

Chen,

Hu,

et al. 2023

Polymers

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An urgently needed approach for the treatment of oral squamous cell carcinoma (OSCC) is the development of novel drug delivery systems that offer targeted specificity and minimal toxic side effects. In this study, we developed an injectable and temperature-sensitive composite hydrogel by combining mesoporous titanium dioxide nanoparticles (MTNs) with Poly(N-isopropylacrylamide) (PNIPAAM) hydrogel to serve as carriers for the model drug Astragalus polysaccharide (APS) using electron beam irradiation. The characteristics of MTNs, including specific surface area and pore size distribution, were analyzed, and the characteristics of MTNs-APS@Hyaluronic acid (HA), such as microscopic morphology, molecular structure, crystal structure, and loading efficiency, were examined. Additionally, the swelling ratio, gel fraction, and microscopic morphology of the composite hydrogel were observed. The in vitro cumulative release curve was plotted to investigate the sustained release of APS in the composite hydrogels. The effects on the proliferation, migration, and mitochondrial membrane potential of CAL-27 cells were evaluated using MTT assay, scratch test, and JC-1 staining. The results indicated successful preparation of MTNs with a specific surface area of 147.059 m2/g and an average pore diameter of 3.256 nm. The composite hydrogel displayed temperature-sensitive and porous characteristics, allowing for slow release of APS. Furthermore, it effectively suppressed CAL-27 cells proliferation, migration, and induced changes in mitochondrial membrane potential. The addition of autophagy inhibitors chloroquine (CQ) and 3-methyladenine (3-MA) attenuated the migration inhibition (p < 0.05).

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