Thermoregulatory dysfunctions in idiopathic Parkinson's disease

Brim, Bianca; Struhal, Walter

doi:10.1016/bs.irmvd.2021.08.009

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…Further research utilizing electrophysiology in behaving animals is necessary to elucidate the specific neural pathways and mechanisms underlying these effects. PD patients exhibit a wide range of non-motor impairments, including alterations in olfactory, auditory, tactile, nociceptive, thermal, and proprioceptive perception (Oppo et al 2020;Jafari, Kolb, and Mohajerani 2020;Kesayan et al 2015;José Luvizutto et al 2020;Brim and Struhal 2021). In our investigation, we focus on tactile sensation mediated through whisker deflection in mice, using the conserved rodent "whisker to barrel" pathway as a reliable model for tactilesensory stimulation and processing.…”

Section: Discussionmentioning

confidence: 99%

“…Diagnosis is based on identifying common motor symptoms such as tremor, bradykinesia (slowed movement), and muscular rigidity. However, PD patients also experience non-motor impairments, including alterations in olfactory, auditory, tactile, nociceptive, thermal, and proprioceptive perception ( Oppo et al 2020 ; Jafari, Kolb, and Mohajerani 2020 ; Kesayan et al 2015 ; José Luvizutto et al 2020 ; Brim and Struhal 2021 ). Notably, these non-motor symptoms, often referred to collectively as sensory symptoms, precede the manifestation of motor symptoms by two or more years ( Pont-Sunyer et al 2015 ), offering a potential window for early diagnostic methods.…”

Section: Introductionmentioning

confidence: 99%

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Sensory-Behavioral Deficits in Parkinson’s Disease: Insights from a 6-OHDA Mouse Model

Linen,

Chang,

Hess

et al. 2024

Preprint

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Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic neurons in the striatum, predominantly associated with motor symptoms. However, non-motor deficits, particularly sensory symptoms, often precede motor manifestations, offering a potential early diagnostic window. The impact of non-motor deficits on sensation behavior and the underlying mechanisms remains poorly understood. In this study, we examined changes in tactile sensation within a Parkinsonian state by employing a mouse model of PD induced by 6-hydroxydopamine (6-OHDA) to deplete striatal dopamine (DA). Leveraging the conserved mouse whisker system as a model for tactile-sensory stimulation, we conducted psychophysical experiments to assess sensory-driven behavioral performance during a tactile detection task in both the healthy and Parkinson-like states. Our findings reveal that DA depletion induces pronounced alterations in tactile sensation behavior, extending beyond expected motor impairments. We observed diverse behavioral deficits, spanning detection performance, task engagement, and reward accumulation, among lesioned individuals. While subjects with extreme DA depletion consistently showed severe sensory behavioral deficits, others with substantial DA depletion displayed minimal changes in sensory behavior performance. Moreover, some exhibited moderate degradation of behavioral performance, likely stemming from sensory signaling loss rather than motor impairment. The implementation of a sensory detection task is a promising approach to quantify the extent of impairments associated with DA depletion in the animal model. This facilitates the exploration of early non-motor deficits in PD, emphasizing the importance of incorporating sensory assessments in understanding the diverse spectrum of PD symptoms.SIGNIFICANCE STATEMENTThis study explores sensory-motor aspects of Parkinson’s disease using a 6-OHDA mouse model. Leveraging the mouse whisker system, we reveal diverse deficits in tactile sensation behavior due to dopamine depletion. Our findings emphasize the importance of sensory assessments in understanding the diverse spectrum of PD symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sensory-Behavioral Deficits in Parkinson’s Disease: Insights from a 6-OHDA Mouse Model

Linen,

Chang,

Hess

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…Blood volume pulse (BVP) ambulatory monitoring is feasible and may be an important marker for WO, as hypotensive episodes are significantly reduced after the continuous infusion of L-dopa [ 26 ]. Alterations in skin temperature (TEMP) (i.e., skin TEMP) may be an important marker for thermoregulatory dysfunction common in PD [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

An Individualized Multi-Modal Approach for Detection of Medication “Off” Episodes in Parkinson’s Disease via Wearable Sensors

Arasteh

Mirian

Verchere

et al. 2023

JPM

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The primary treatment for Parkinson’s disease (PD) is supplementation of levodopa (L-dopa). With disease progression, people may experience motor and non-motor fluctuations, whereby the PD symptoms return before the next dose of medication. Paradoxically, in order to prevent wearing-off, one must take the next dose while still feeling well, as the upcoming off episodes can be unpredictable. Waiting until feeling wearing-off and then taking the next dose of medication is a sub-optimal strategy, as the medication can take up to an hour to be absorbed. Ultimately, early detection of wearing-off before people are consciously aware would be ideal. Towards this goal, we examined whether or not a wearable sensor recording autonomic nervous system (ANS) activity could be used to predict wearing-off in people on L-dopa. We had PD subjects on L-dopa record a diary of their on/off status over 24 hours while wearing a wearable sensor (E4 wristband®) that recorded ANS dynamics, including electrodermal activity (EDA), heart rate (HR), blood volume pulse (BVP), and skin temperature (TEMP). A joint empirical mode decomposition (EMD) / regression analysis was used to predict wearing-off (WO) time. When we used individually specific models assessed with cross-validation, we obtained > 90% correlation between the original OFF state logged by the patients and the reconstructed signal. However, a pooled model using the same combination of ASR measures across subjects was not statistically significant. This proof-of-principle study suggests that ANS dynamics can be used to assess the on/off phenomenon in people with PD taking L-dopa, but must be individually calibrated. More work is required to determine if individual wearing-off detection can take place before people become consciously aware of it.

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Thermoregulatory dysfunctions in idiopathic Parkinson's disease

Cited by 2 publications

References 28 publications

Sensory-Behavioral Deficits in Parkinson’s Disease: Insights from a 6-OHDA Mouse Model

Sensory-Behavioral Deficits in Parkinson’s Disease: Insights from a 6-OHDA Mouse Model

An Individualized Multi-Modal Approach for Detection of Medication “Off” Episodes in Parkinson’s Disease via Wearable Sensors

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