Thermoregulatory and maternal nestbuilding in Syrian hamsters: Interaction of ovarian steroids and energy demand

Bhatia, Anita J.; Schneider, Jill E.; Wade, George N.

doi:10.1016/0031-9384(95)00039-l

Cited by 5 publications

(6 citation statements)

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“…Nest building behavior is normally performed by both male and female mice, and has been suggested to be correlated with thermoregulation and with the function of the hippocampus (50)(51)(52). Nest building behavior is normally performed by both male and female mice, and has been suggested to be correlated with thermoregulation and with the function of the hippocampus (50)(51)(52).…”

Section: Indications From Various Tr4 Knockout Mouse Modelsmentioning

confidence: 99%

The roles of testicular orphan nuclear receptor 4 (TR4) in cerebellar development

et al. 2008

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Since Testicular Receptor 4 (TR4) was cloned, efforts have been made to elucidate its physiological function. To examine the putative functions of TR4, the conventional TR4 knockout (TR4(-/-)) mouse model was generated. Throughout postnatal and adult stages, TR4(-/-) mice exhibited behavioral deficits in motor coordination, suggesting impaired cerebellar function. Histological examination of the postnatal and adult TR4(-/-) cerebellum revealed gross abnormalities in foliation. Further analyses demonstrated changes in the lamination of the TR4(-/-) cerebellar cortex, including reduction in the thickness of both the molecular layer (ML) and the internal granule layer (IGL). Analyses of the developing TR4(-/-) cerebellum indicate that the lamination irregularities observed may result from disrupted granule cell proliferation within the external granule cell layer (EGL), delayed inward migration of post-mitotic granule cells, and increased apoptosis during cerebellar development. In addition, abnormal development of Purkinje cells was observed in the postnatal TR4(-/-) cerebellum, as indicated by aberrant dendritic arborization. In postnatal, neuronal-specific TR4 knockout mice, architectural changes in the cerebellum were similar to those seen in TR4(-/-) animals, suggesting that TR4 function in neuronal lineages might be important for cerebellar morphogenesis, and that the effect on Purkinje cell development is likely mediated by changes elsewhere, such as in granule cells, or is highly dependent on developmental stage. Together, our findings from various TR4 knockout mouse models suggest that TR4 is required for normal cerebellar development and that failure to establish proper cytoarchitecture results in dysfunction of the cerebellum and leads to abnormal behavior.

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Section: Indications From Various Tr4 Knockout Mouse Modelsmentioning

confidence: 99%

The roles of testicular orphan nuclear receptor 4 (TR4) in cerebellar development

et al. 2008

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“…Bhatia and colleagues (Bhatia et al, 1995) found that nest building was increased in Syrian hamsters (Mesocricetus auratus) during the last 4days of gestation, suggesting these animals used additional behavioural strategies to conserve heat loss. In pregnant rats and mice, however, there were no major changes in the mitochondrial content of brown adipose tissue (BAT) which would be expected to be associated with changed thermogenesis (Andrews et al, 1986;Villarroya et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Limits to sustained energy intake. XVI. Body temperature and physical activity of female mice during pregnancy

Gamo

Bernard

Mitchell

et al. 2013

Journal of Experimental Biology

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SUMMARYLactation is the most energy-demanding phase of mammalian reproduction, and lactation performance may be affected by events during pregnancy. For example, food intake may be limited in late pregnancy by competition for space in the abdomen between the alimentary tract and fetuses. Hence, females may need to compensate their energy budgets during pregnancy by reducing activity and lowering body temperature. We explored the relationships between energy intake, body mass, body temperature and physical activity throughout pregnancy in the MF1 mouse. Food intake and body mass of 26 females were recorded daily throughout pregnancy. Body temperature and physical activity were monitored every minute for 23h a day by implanted transmitters. Body temperature and physical activity declined as pregnancy advanced, while energy intake and body mass increased. Compared with a pre-mating baseline period, mice increased energy intake by 56% in late pregnancy. Although body temperature declined as pregnancy progressed, this served mostly to reverse an increase between baseline and early pregnancy. Reduced physical activity may compensate the energy budget of pregnant mice but body temperature changes do not. Over the last 3days of pregnancy, food intake declined. Individual variation in energy intake in the last phase of pregnancy was positively related to litter size at birth. As there was no association between the increase in body mass and the decline in intake, we suggest the decline was not caused by competition for abdominal space. These data suggest overall reproductive performance is probably not constrained by events during pregnancy. Supplementary material available online at

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“…Metabolic changes, including reproductive hormones, are strongly linked to changes in food hoarding, though exact details vary by species (Keen-Rhinehart et al 2010). In contrast with many animals golden hamsters in the laboratory do not increase food intake during pregnancy (Zucker et al 1972;Fleming 1978;Wade et al 1986;Quek and Trayhurn 1990;Bhatia and Wade 1991; but see Bhatia et al 1995), relying instead on internal stores of energy (Quek and Trayhurn 1990;Garton et al 1994). Using these internal stores of energy results in mothers who, at the end of their pregnancy, have a 72% decrease in the amount of white adipose tissue (Wade et al 1986).…”

Section: Talpa Europaeamentioning

confidence: 83%

“…Hamsters in the laboratory do increase food intake during lactation, even doubling their intake in some cases (Fleming 1978;Fleming and Miceli 1983;Bhatia et al 1995). These hamsters have exhausted most of their stored energy during pregnancy (Wade et al 1986), and thus must rely on increased external energy sources.…”

Section: Talpa Europaeamentioning

confidence: 97%

“…In addition, lactation is a much more energy-intensive process than gestation (Hsu et al 1999). The extent of the increase in food intake depends on litter size (Fleming 1978), temperature (Bhatia et al 1995), and type of food (Fleming and Miceli 1983). The mother's increase in food intake, coupled with her pups' consumption of stored food as they wean, may require an increased foraging effort near the end of lactation as the food hoard dwindles.…”

Section: Talpa Europaeamentioning

confidence: 98%

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Foraging behavior of golden hamsters (Mesocricetus auratus) in the wild

Larimer

Fritzsche

Song

et al. 2010

J Ethol

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Foraging theory posits that animals should maximize energy gains while minimizing risks, the largest of which is usually predation. For small burrowing mammals the best measure of risk avoidance may be the time spent in the burrow, although this measure is rarely examined. During the spring of 2005 and 2006 we recorded the foraging behavior of female golden hamsters in their natural habitat in southern Turkey. Data were collected with a data logger and by direct observations. Female golden hamsters averaged 64 min per day above ground in a series of foraging trips with a mean duration of 5.5 min. Two nursing females increased their time out of the burrow by a factor of 6-8 times over the course of 16 days by increasing both the number of trips and the length of each trip. These results show that hamsters spend little time out of the burrow, thus minimizing risk, but they also show that time spent out of the burrow is related to the energy needs of the hamsters; lactating females with high energy needs exposed themselves to much greater risk than did nonlactating females.

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Thermoregulatory and maternal nestbuilding in Syrian hamsters: Interaction of ovarian steroids and energy demand

Cited by 5 publications

References 26 publications

The roles of testicular orphan nuclear receptor 4 (TR4) in cerebellar development

The roles of testicular orphan nuclear receptor 4 (TR4) in cerebellar development

Limits to sustained energy intake. XVI. Body temperature and physical activity of female mice during pregnancy

Foraging behavior of golden hamsters (Mesocricetus auratus) in the wild

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