Thermoregulation in mice treated with parathion, carbaryl, or DDT

Ahdaya, S.M.; Shah, P.V.; Guthrie, F. E.

doi:10.1016/0041-008x(76)90079-x

Cited by 41 publications

(8 citation statements)

References 9 publications

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“…Ahdaya et al . () reported that the LD50 dose of either OP or carbamate pesticides was reduced by as much as a factor of 5 at both higher and lower temperatures in mice, indicating that exposed animals were unable to adequately thermoregulate, and Jaques () documented similar interactions between temperature and AR compounds. Given that fisher exposure to these contaminants peaks in the spring (Gabriel et al .…”

Section: Discussionmentioning

confidence: 98%

Impacts of Rodenticide and Insecticide Toxicants from Marijuana Cultivation Sites on Fisher Survival Rates in the Sierra National Forest, California

Thompson

Sweitzer²,

Gabriel³

et al. 2013

Conservation Letters

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Secondary exposure of wildlife to pesticides has been well documented, yet exposure is typically associated with agricultural or wildland-urban interface areas. Wildlife in undeveloped areas is generally presumed free from risk. In 2009, a male fisher was found dead in the Sierra National Forest and subsequent necropsy revealed that the animal died of acute rodenticide poisoning. Follow-up testing revealed that 85% of fisher carcasses recovered by two research projects in the previous three years tested positive for rodenticides. Concern arose that exposure could predispose an animal to mortality from other causes, and that the underlying role of toxicants would escape notice. Further investigation indicated that the most likely source was the numerous illegal marijuana cultivation sites currently found on public lands throughout the western United States. To determine whether the presence of cultivation sites predisposed fishers to mortality from other sources, we related survival rates to the presence and number of cultivation sites found within that animal's home range over the past 10 years. Likelihood of exposure was related to the presence of cultivation sites, and female fisher survival was influenced by the number of cultivation sites within its home range. We discuss the conservation implications of this unexpected relationship.

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Section: Discussionmentioning

confidence: 98%

Impacts of Rodenticide and Insecticide Toxicants from Marijuana Cultivation Sites on Fisher Survival Rates in the Sierra National Forest, California

Thompson

Sweitzer²,

Gabriel³

et al. 2013

Conservation Letters

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“…Organophosphate ingestion impairs thermoregulatory abilities in birds and mammals within hours of poisoning [33]. For example, high doses of OP pesticides in mice [34] and rats [35] caused hypothermia within 1 to 3 h of ingestion; American kestrels ( Falco sparvarius ) incurred transient but pronounced hypothermia 2 h after ingesting methyl parathion [25]. The bases for this thermoregulatory impairment could be reduced peripheral thermogenesis (at muscular level) or disrupted central hypothalamic control or both.…”

Section: Discussionmentioning

confidence: 99%

Effects of sublethal fenitrothion ingestion on cholinesterase inhibition, standard metabolism, thermal preference, and prey‐capture ability in the Australian central bearded dragon (Pogona vitticeps, agamidae)

Bain

Buttemer

Astheimer

et al. 2004

Enviro Toxic and Chemistry

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The central bearded dragon (Pogona vitticeps) is a medium-sized lizard that is common in semiarid habitats in Australia and that potentially is at risk of fenitrothion exposure from use of the chemical in plague locust control. We examined the effects of single sublethal doses of this organophosphate (OP; low dose = 2.0 mg/kg; high dose = 20 mg/kg; control = vehicle alone) on lizard thermal preference, standard metabolic rate, and prey-capture ability. We also measured activities of plasma total cholinesterase (ChE) and acetylcholinesterase before and at 0, 2, 8, 24, 120, and 504 h after OP dosing. Predose plasma total ChE activity differed significantly between sexes and averaged 0.66 +/- 0.06 and 0.45 +/- 0.06 micromol/min/ml for males and females, respectively. Approximately 75% of total ChE activity was attributable to butyrylcholinesterase. Peak ChE inhibition reached 19% 2 h after OP ingestion in the low-dose group, and 68% 8 h after ingestion in high-dose animals. Neither OP doses significantly affected diurnal body temperature, standard metabolic rate, or feeding rate. Plasma total ChE levels remained substantially depressed up to 21 d after dosing in the high-dose group, making this species a useful long-term biomonitor of OP exposure in its habitat.

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“…25 Carbaryl produces behavioral changes in rodents such as tremor 26 and hypothermia. 27 Furthermore, a recent study reports age-specific sensitivity to carbaryl in Brown-Norway rats indicative of age-related changes in metabolism. Even low-dose (3 mg/kg) carbaryl treatment exhibits these age-specific differences in both biochemical and behavioral experiments.…”

Section: Introductionmentioning

confidence: 99%

Carbamate Insecticides Target Human Melatonin Receptors

Popovska-Gorevski

Dubocovich

Rajnarayanan

2017

Chem. Res. Toxicol.

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Carbaryl (1-naphthyl methylcarbamate) and carbofuran (2,3-dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate) are among the most toxic insecticides, implicated in a variety of diseases including diabetes and cancer among others. Using an integrated pharmacoinformatics based screening approach, we have identified these insecticides to be structural mimics of the neurohormone melatonin and were able to bind to the putative melatonin binding sites in MT1 and MT2 melatonin receptors in silico. Carbaryl and carbofuran then were tested for competition with 2-[125I]-iodomelatonin (300 pM) binding to hMT1 or hMT2 receptors stably expressed in CHO cells. Carbaryl and carbofuran showed higher affinity for competition with 2-[125I]-iodomelatonin binding to the hMT2 compared to the hMT1 melatonin receptor (33 and 35-fold difference, respectively) as predicted by the molecular modeling. In the presence of GTP (100 μM), which decouples the G-protein linked receptors to modulate signaling, the apparent efficacy of carbaryl and carbofuran for 2-[125I]-iodomelatonin binding for the hMT1 melatonin receptor was not affected but significantly decreased for the hMT2 melatonin receptor compatible with receptor antagonist/inverse agonist and agonist efficacy, respectively. Altogether, our data points to a potentially new mechanism through which carbamate insecticides carbaryl and carbofuran could impact human health by altering the homeostatic balance of key regulatory processes by directly binding to melatonin receptors.

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Thermoregulation in mice treated with parathion, carbaryl, or DDT

Cited by 41 publications

References 9 publications

Impacts of Rodenticide and Insecticide Toxicants from Marijuana Cultivation Sites on Fisher Survival Rates in the Sierra National Forest, California

Impacts of Rodenticide and Insecticide Toxicants from Marijuana Cultivation Sites on Fisher Survival Rates in the Sierra National Forest, California

Effects of sublethal fenitrothion ingestion on cholinesterase inhibition, standard metabolism, thermal preference, and prey‐capture ability in the Australian central bearded dragon (Pogona vitticeps, agamidae)

Carbamate Insecticides Target Human Melatonin Receptors

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