Thermoregulation and Sleep: Functional Interaction and Central Nervous Control

Cerri, Matteo; Amici, Roberto

doi:10.1002/cphy.c140012

Cited by 8 publications

(6 citation statements)

References 239 publications

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“…Sleep and wakefulness are characterized by specific autonomic states, activity and physiological effects. For example, during non-rapid eye movement sleep (NREM), autonomic activity changes as does its interaction with endocrine, respiratory, cardiovascular and thermoregulatory systems (reviewed in Cerri) [ 41 ]. Considerable autonomic variation is observed in each stage of sleep (wakefulness, NREM sleep, and REM sleep) [ 42 ].…”

Section: Anatomy Of the Autonomic Nervous Systemmentioning

confidence: 99%

Autonomic dysfunction in SARS-COV-2 infection acute and long-term implications COVID-19 editor’s page series

Becker

2021

J Thromb Thrombolysis

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The autonomic nervous system (ANS) is a complex network of nerves originating in the brain, brain stem, spinal cord, heart and extracardiac organs that regulates neural and physiological responses to internal and external environments and conditions. A common observation among patients with the 2019 Coronavirus (CoV) (SARS-severe acute respiratory syndrome CoV-2) (SARS-CoV-2) or COVID-19 [ CO for corona, VI for virus, D for disease and 19 for when the outbreak was first identified (31 December 2019)] in the acute and chronic phases of the disease is tachycardia, labile blood pressure, muscular fatigue and shortness of breath. Because abnormalities in the ANS can contribute to each of these symptoms, herein a review of autonomic dysfunction in SARS-COV-2 infection is provided to guide diagnostic testing, patient care and research initiatives. Graphic abstract The autonomic nervous system is a complex network of nerves originating in the brain, brain stem, spinal cord, heart and extracardiac organs that regulates neural and physiological responses to internal and external environments and conditions. A common collection of signs and symptoms among patients with the 2019 Coronavirus (CoV) (SARS-severe acute respiratory syndrome CoV-2) (SARS-CoV-2) or COVID-19 [ CO for corona, VI for virus, D for disease and 19 for when the outbreak was first identified (31 December 2019)] is tachycardia, labile blood pressure, muscular fatigue and shortness of breath. Abnormalities in the autonomic nervous system (ANS) can contribute to each of these identifiers, potentially offering a unifying pathobiology for acute, subacute and the long-term sequelae of SARS-CoV-2 infection (PASC) and a target for intervention.

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Section: Anatomy Of the Autonomic Nervous Systemmentioning

confidence: 99%

Autonomic dysfunction in SARS-COV-2 infection acute and long-term implications COVID-19 editor’s page series

Becker

2021

J Thromb Thrombolysis

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“…Besides a potential role in memory consolidation ( Boyce et al, 2016 ), REM sleep, although rather passive, appears to be involved in thermoregulation ( Kavanau, 1997 ; Komagata et al, 2019 ; Cerri and Amici, 2021 ). Total sleep deprivation and selective REM sleep deprivation induce hypothermia, which even lead to death in rats ( Rechtschaffen and Bergmann, 2002 ).…”

Section: Special Topicsmentioning

confidence: 99%

Women’s mood at high altitude. sexual dimorphism in hypoxic stress modulation by the tryptophan–melatonin axis

et al. 2023

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Sexual (and gender)-dimorphism in tolerance to hypobaric hypoxia increasingly matters for a differential surveillance of human activities at high altitude (HA). At low altitudes, the prevalence of anxiety and depression in women has already been found to double when compared with men; it could be expected to even increase on exposure to HA. In purposefully caring for the health of women at HA, the present work explores the potential involvement of the tryptophan (Trp)–melatonin axis in mood changes on exposure to hypobaric hypoxia. The present work highlights some already known anxiogenic effects of HA exposure. Hypoxia and insomnia reduce serotonin (5-HT) availability; the latter defect being expressed as failure of brown adipose tissue (BAT) activation and mood disorders. Rapid eye movement (REM) sleep organization and synapsis restoration that are additionally affected by hypoxia impair memory consolidation. Affective complaints may thus surge, evolving into anxiety and depression. Sex-related differences in neural network organization and hormonal changes during the menstrual cycle, and certainly also during the life cycle, underscore the possibility of 5-HT–related mood alterations, particularly in women on HA exposure. The mean brain rate of 5-HT synthesis at sea level is already 1.5-fold higher in males than in females. sexual dimorphism also evidences the overexpression effects of SERT, a 5-HT transporter protein. Gonadal and thyroid hormones, as influenced by HA exposure, further modulate 5-HT availability and its effects in women. Besides caring for adequate oxygenation and maintenance of one’s body core temperature, special precautions concerning women sojourning at HA should include close observations of hormonal cycles and, perhaps, also trials with targeted antidepressants.

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“…the reduced energetic demands bestowed by sleep (Cerri & Amici, 2021;Schmidt, 2014). The relatively active morning and evening schedules during Winter likely serve a mixture of nutritional and territorial demands for the red squirrel.…”

Section: Ultradian Sleep Rhythmsmentioning

confidence: 99%

“…While increased sleep variability across individuals in Winter likely dilutes the effect in the aggregate, our rhythmicity analysis suggests Winter ultradian rhythms are the strongest of all seasons. Because North American red squirrels do not hibernate or engage in torpor (Brigham & Geiser, 2012), they have high thermoregulatory demands throughout the year, which may be met by increasing time spent in the nest (by staying warm) while benefiting from the reduced energetic demands bestowed by sleep (Cerri & Amici, 2021;Schmidt, 2014). The relatively active morning and evening schedules during Winter likely serve a mixture of nutritional and territorial demands for the red squirrel.…”

Section: Ultradian Sleep Rhythmsmentioning

confidence: 99%

Using a Homeogram to Detect Sleep in Free-living Animals

Gaidica

Studd

Wishart

et al. 2021

Preprint

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Sleep is appreciated as a behavior critical to homeostasis, performance, and fitness. Yet, most of what we know about sleep comes from humans or controlled laboratory experiments. Assessing sleep in wild animals is challenging, as it is often hidden from view, and electrophysiological recordings that define sleep states are difficult to obtain. Accelerometers have offered great insight regarding gross movement, although ambiguous quiescent states like sleep have been largely ignored, limiting our understanding of this ubiquitous behavior. We developed a broadly applicable sleep detection method called a homeogram that can be applied to accelerometer data collected from wild animals. We applied our methodology to detect sleep in free-ranging North American red squirrels (Tamiasciurus hudsonicus) in a region that experiences drastic seasonal shifts in light, temperature, and behavioral demands. Our method characterized sleep in a manner consistent with limited existing studies and expanded those observations to provide evidence that red squirrels apply unique sleep strategies to cope with changing environments. Applying our analytical strategy to accelerometer data from other species may open new possibilities to investigate sleep patterns for researchers studying wild animals.

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Thermoregulation and Sleep: Functional Interaction and Central Nervous Control

Cited by 8 publications

References 239 publications

Autonomic dysfunction in SARS-COV-2 infection acute and long-term implications COVID-19 editor’s page series

Autonomic dysfunction in SARS-COV-2 infection acute and long-term implications COVID-19 editor’s page series

Women’s mood at high altitude. sexual dimorphism in hypoxic stress modulation by the tryptophan–melatonin axis

Using a Homeogram to Detect Sleep in Free-living Animals

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