Thermoradiotherapy for Intraocular Tumors

Finger, Paul T.; Packer, Samuel; Svitra, Paul P.; Paglione, R.W.; Anderson, Lowell L.; Kim, Jaehwan; Jakobiec, Frederick A.

doi:10.1001/archopht.1985.01050100150039

Cited by 47 publications

(5 citation statements)

References 23 publications

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“…Microwave Plaque [3,12,[16][17][18]]. An anten na integrated in a plaque emits microwaves, which arc converted into heat in the tissue.…”

Section: Inductive Methods Focused Ultrasoundsupporting

confidence: 39%

“…This decline is much less pronounced than with current microwave or ferromagnet ic plaques (-1°C) [3,12,23]; it is even some what less pronounced than with LCF plaques (0.3°C) [20]. The decrease in intraocular tem perature in tumor-containing eyes has been demonstrated to be even less rapid than in tumor-free eyes [24], According to Finger et al [3,12], plaque temperatures up to 47 °C may be tolerated .With the warm-water perfu- sion plaque and an inflow temperature of 45°C, therapeutic temperature levels may thus be reached at a depth exceeding 10 mm. The sclera has earlier been shown to readily tolerate the amounts of heat required to use hyperthermia as a therapeutic modality for choroidal melanoma [28].…”

Section: Discussionmentioning

confidence: 45%

“…For a given dose, the proportion of cancer cells killed is in creased, thereby reducing the probability of spread and recurrence [3], This synergistic ef fect is greatest when hyperthermia is applied simultaneously with irradiation [4][5][6]. This al so applies for experimental choroidal mela noma [7], Hyperthermia is already being used as a routine technique in other fields of oncology [8,9], Intraocular tumors offer unique condi tions for this treatment modality: they arc small and well dclincable.…”

Section: Introductionmentioning

confidence: 51%

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A Warm-Water Perfusion Plaque for Hyperthermic Treatment of Intraocular Tumors

Menapace¹,

Handl-Zeller²,

Huber

et al. 1993

Ophthalmologica

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This paper describes the design and performance of a plaque aimed at delivering hot-water hyperthermia to intraocular tumors. The plaque transfers heat into the tissues via conduction. Maximum temperature cannot exceed inflow water temperature. The high water flow rate provided by the hyperthermia unit guarantees an excessive power output at a constant temperature level, resulting in a homogeneous temperature distribution in the tissue. Heat distribution over the plaque surface was shown to be uniform. System performance has been studied on enucleated human as well as on living rabbit eyes. Thermal mapping was done in two and one planes, respectively, and the spatial distribution was calculated. Results promise therapeutic temperature levels to a depth exceeding 10 mm.

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“…Microwave Plaque [3,12,[16][17][18]]. An anten na integrated in a plaque emits microwaves, which arc converted into heat in the tissue.…”

Section: Inductive Methods Focused Ultrasoundsupporting

confidence: 39%

Section: Discussionmentioning

confidence: 45%

Section: Introductionmentioning

confidence: 51%

See 1 more Smart Citation

A Warm-Water Perfusion Plaque for Hyperthermic Treatment of Intraocular Tumors

Menapace¹,

Handl-Zeller²,

Huber

et al. 1993

Ophthalmologica

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“…There have been two enucleations, one in patient 10 for glaucomatous complications of a bilateral uveitis 39 months after treatment, the second in patient 19 for rubeotic glaucoma 19 months after treatment. Ten patients have developed some form of secondary retinopathy (Table 3B).…”

Section: Resultsmentioning

confidence: 99%

Microwave plaque thermoradiotherapy for choroidal melanoma.

Finger

1992

British Journal of Ophthalmology

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Microwave thermoradiotherapy was used as a primary treatment for 44 patients with choroidal melanoma. An episcleral dishshaped microwave antenna was placed beneath the tumour at the time of plaque brachytherapy. While temperatures were measured at the sclera, the tumour's apex was targeted to receive a minimum of 42°C for 45 minutes. In addition, the patients received full or reduced doses of plaque radiotherapy. No patients have been lost to foliow-up. Two eyes have been enucleated: one for rubeotic glaucoma, and one for uveitic glaucoma. Though six patients have died, only one death was due to metastatic choroidal melanoma (39 months after treatment). Clinical observations suggest that the addition of microwave heating to plaque radiation therapy of choroidal melanoma has been weli tolerated. There has been a 97-7% local control rate (with a mean follow-up of 22.2 months). We have reduced the minimum tumour radiation dose (apex dose) to levels used for thermoradiotherapy of cutaneous melanomas (50 Gy/5000 rad). Within the range of this foliow-up period no adverse effects which might preclude the use of this microwave heat delivery system for treatment of choroidal melanoma have been noted.

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“…Com base nestas afirmações, tratamentos alternativos, pelo menos tão efetivos quanto à enucleação, mas que protejam a vida huma-na com manutenção de olhos e de visão, se impõem. Contudo, há estudos para outros tratamentos os quais incluem: fotocoagulação (16)(17) , crioterapia (18) , excisão local (19) , ressecção tumoral em bloco (20) , radioterapia (21) , radioterapia térmica (22) , quimioterapia (23) , imunoterapia (24) e fotocoagulação com "excimer" laser (25) . Destes, a radiação braquiterápica (26) e a radiação externa (27) são as mais freqüentemente utilizadas.…”

Section: Discussionunclassified

Avaliação da área de melanomas amelanóticos de coróide em coelhos: modelo matemático

Ramos

Costa

Rossi

et al. 2002

Arq. Bras. Oftalmol.

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Objetivo: Os métodos terapêuticos para o tratamento dos melanomas de coróide incluem a observação, a radioterapia, a cirurgia e a laserterapia. Para acompanhamento do crescimento tumoral, há necessidade de documentação e medida do tamanho desses tumores. O objetivo deste estudo é apresentar um modelo matemático simples e de baixo custo, para medida de áreas desses tumores do fundo de olho. Métodos: Utilizaram-se 25 olhos de coelhos pigmentados. Fragmentos de melanomas amelanóticos de hamster foram implantados cirurgicamente no espaço supracoroideo dos olhos dos animais. Quando os tumores atingiram 3 a 4 diâmetros papilares de tamanho realizaram-se as retinografias e angiografias fluorescentes com retinógrafo sem Imaginet, com foco fixo. Por meio de cálculos matemáticos verificaram-se as áreas reais dos tumores. Resultados: Foi possível verificar as áreas reais dos tumores e na análise da comparação dos valores das médias obtidas para os tumores, verificou-se que não existiu diferença estatisticamente significativa entre eles (p= 0,717). Conclusões: Concluiu-se neste estudo, que com o uso de retinógrafo sem Imaginet, foi possível medir com acurácia e segurança, por meio de cálculo matemático, a área de melanomas amelanóticos de hamster implantados no espaço supracoroídeo de coelhos. An assessment of rabbit's choroidal amelanotic melanomas area. Mathematical model

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Thermoradiotherapy for Intraocular Tumors

Cited by 47 publications

References 23 publications

A Warm-Water Perfusion Plaque for Hyperthermic Treatment of Intraocular Tumors

A Warm-Water Perfusion Plaque for Hyperthermic Treatment of Intraocular Tumors

Microwave plaque thermoradiotherapy for choroidal melanoma.

Avaliação da área de melanomas amelanóticos de coróide em coelhos: modelo matemático

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