Thermoplastic modification of medical grade polyvinyl chloride with various antibiotics: effect of antibiotic chemical structure on mechanical, antibacterial properties, and release activity

Merchan, Martha; Sedlaříková, Jana; Friedrich, Miha; Sedlařík, Vladimír; Sáha, Petr

doi:10.1007/s00289-011-0474-3

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…The antibacterial properties of the electrospun nanofibers were evaluated from the samples of PVB (10 wt%) and PVB/MAG 10 (3 wt%) nanofibrous membranes by three different methods, described below: (a) agar disk diffusion method [ 42 ], (b) dynamic cultivation method, modified according to the literature [ 11 , 37 ] and (c) contact method in accordance with ISO 22196:2011 [ 43 ]. The agar disk diffusion method encompassed the following: circular samples (9 mm in diameter) of nanofibers from neat PVB or PVB enriched with MAG 10 (3 wt%) on nonwoven textile were placed on agar plates previously inoculated with 1 mL of 0.5 McF turbid bacterial suspension ( Escherichia coli , Staphylococcus aureus ) in sterile saline solution.…”

Section: Methodsmentioning

confidence: 99%

Section: Antibacterial Activitymentioning

confidence: 99%

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Novel Polyvinyl Butyral/Monoacylglycerol Nanofibrous Membrane with Antifouling Activity

et al. 2020

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Monoacylglycerols (MAGs) have proven of great interest to the foodstuffs industry due to the promising antibacterial activity they show for controlling microbial contamination. Prior to this paper, this antibacterial agent had not been incorporated in a nanofibrous membrane. This study details convenient fabrication of nanofibrous membranes based on polyvinyl butyral (PVB) containing various concentrations of monocaprin (MAG 10) by an electrospinning process. Increasing the concentration of MAG 10 caused differences to appear in the shape of the nanofibers, in addition to which the level of wettability was heightened. Besides exhibiting antibacterial properties, the functional membranes demonstrated especially good antifouling activity. The novel and efficient nanofibrous membranes described have the potential to find eventual application in medical or environmental fields.

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Section: Methodsmentioning

confidence: 99%

Section: Antibacterial Activitymentioning

confidence: 99%

Novel Polyvinyl Butyral/Monoacylglycerol Nanofibrous Membrane with Antifouling Activity

et al. 2020

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“…di-(2-ethylhexyl) phthalate, used as plasticizer in PVC production [39], and also their surfaces can be prone to microbial biofilm formation, causing nosocomial infections. Several approaches are proposed in order to eliminate these type of infections: incorporating antibiotics on polymer surfaces [40] or coating with poly(vinyl alcohol) films containing nanosilver particles. Since heparin is the most effective anticoagulant substance, there have been trials to produce PVC-heparin complexes, with addition of dextran and iron (III) by electrostatic interaction.…”

Section: Other Polymeric Materialsmentioning

confidence: 99%

Thermoplastic Elastomers: Materials for Heart Assist Devices

Piegat¹,

Fray²

2016

Polim. Med.

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Heart assisting devices have become a standard element in clinical practice and provide support for the traditional methods of treating heart disease. Regardless of the construction of VAD (ventricular assist devices), there are crucial requirements that have to be met by the construction materials: high purity, desired physical, chemical and mechanical properties, easy fabrication and high stability and susceptibility to sterilization. They must not cause thrombosis, destroy cellular elements, alter plasma protein, destroy enzymes, deplete electrolytes, cause immune response and cancer, and must not produce toxic and allergic reactions, when they are applied in direct contact with biological tissues and fluids. This paper provides an overview of the polymeric materials as construction materials for cardiovascular support systems, focusing on the group of thermoplastic elastomers, mainly polyurethane and polyester based ones. It also highlights the advantages and disadvantages of currently used materials and the progress in the design of new materials with potential application in the biomedical field.

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“…In spite of the remarkable potential that the BAPS have revealed, they lack inherent attributes such as bactericidal or bacteriostatic properties, whereby the BAPS in the medical field might be focused on the appeasement of healthcare-associated infections which boosts health systems costs. As an approach for facing bacteria colonization, controlled released drug systems from polymeric matrixes might be catalogued as an auspicious solution [16,17].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of a Bioartificial Polymeric System with Potential Antibacterial Activity: Chitosan-Polyvinyl Alcohol-Ampicillin

et al. 2018

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Bio-artificial polymeric systems are a new class of polymeric constituents based on blends of synthetic and natural polymers, designed with the purpose of producing new materials that exhibit enhanced properties with respect to the individual components. In this frame, a combination of polyvinyl alcohol (PVA) and chitosan, blended with a widely used antibiotic, sodium ampicillin, has been developed showing a moderate behavior in terms of antibacterial properties. Thus, aqueous solutions of PVA at 1 wt.% were mixed with acid solutions of chitosan at 1 wt.%, followed by adding ampicillin ranging from 0.3 to 1.0 wt.% related to the total amount of the polymers. The prepared bio-artificial polymeric system was characterized by FTIR, SEM, DSC, contact angle measurements, antibacterial activity against Staphylococcus aureus and Escherichia coli and antibiotic release studies. The statistical significance of the antibacterial activity was determined using a multifactorial analysis of variance with ρ < 0.05 (ANOVA). The characterization techniques did not show alterations in the ampicillin structure and the interactions with polymers were limited to intermolecular forces. Therefore, the antibiotic was efficiently released from the matrix and its antibacterial activity was preserved. The system disclosed moderate antibacterial activity against bacterial strains without adding a high antibiotic concentration. The findings of this study suggest that the system may be effective against healthcare-associated infections, a promising view in the design of novel antimicrobial biomaterials potentially suitable for tissue engineering applications.

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Thermoplastic modification of medical grade polyvinyl chloride with various antibiotics: effect of antibiotic chemical structure on mechanical, antibacterial properties, and release activity

Cited by 6 publications

References 37 publications

Novel Polyvinyl Butyral/Monoacylglycerol Nanofibrous Membrane with Antifouling Activity

Novel Polyvinyl Butyral/Monoacylglycerol Nanofibrous Membrane with Antifouling Activity

Thermoplastic Elastomers: Materials for Heart Assist Devices

Synthesis and Characterization of a Bioartificial Polymeric System with Potential Antibacterial Activity: Chitosan-Polyvinyl Alcohol-Ampicillin

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