Thermomicroscopy in the Analysis of Pharmaceuticals. Von M. Kuhnert‐Brandstätter. 405 Seiten. Pergamon‐Press, Oxford 1971. Preis 10,–

Kovar, K.‐A.

doi:10.1002/ardp.19723050622

Cited by 5 publications

(2 citation statements)

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“…It is estimated that approximately two-thirds of all organic compounds are able to convert from the solid to the gaseous state on heating. 1 A recent molecular-dynamics study of the sublimation of urea was able to reproduce experimental data and may lead to a better understanding of the sublimation process. 2 However, sublimation is not normally a first choice crystallization method, despite the wide range of experimental setups that have been developed for crystal growth by sublimation and its use in industry.…”

Section: ■ Introductionmentioning

confidence: 99%

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Applications of Low Temperature Gradient Sublimation in Vacuo: Rapid Production of High Quality Crystals. The First Solvent-Free Crystals of Ethinyl Estradiol

Karpinska

Erxleben

McArdle

2013

Crystal Growth & Design

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A sublimation method based on the use of a conventional vacuum oven has been developed to extend the method's range of applications. The use of a small, externally controlled heater has increased the temperature range from 80− 200 to 80−500 °C and provides high-quality crystals of compounds ranging from oxalic acid to metal-free phthalocyanine. Some unique benefits of the method are relatively rapid crystal production, provision of crystals of compounds that are known only as solvates, simple optical detection of crystals that are likely to bend, and crystal habit control. The inability of ethynyl estradiol (EE) to form solvent-free crystals is explained on the basis of the structure of vapor-grown crystals, and three new solvate structures are reported. The visual detection of bending crystals of naftazone and 1,3-dinitrobenzene is described. The crystal morphologies of 1,4-naphthaquinone, metal-free phthalocyanine, and benzoic acid are controlled by the temperature gradient in the oven.

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Section: ■ Introductionmentioning

confidence: 99%

“…It is estimated that approximately two-thirds of all organic compounds are able to convert from the solid to the gaseous state on heating . A recent molecular-dynamics study of the sublimation of urea was able to reproduce experimental data and may lead to a better understanding of the sublimation process .…”

Section: Introductionmentioning

confidence: 99%