Thermoinduced Radical Cyclization for the Synthesis of Sultines
Zhiming Zhu,
Zhengxi Deng,
Chenglong Xuan
et al.
Abstract:A thermoinduced radical homolytic substitution cyclization of alkenyl tethered sulfinate esters was displayed under mild metal-free conditions, enabling the functionalization of alkenes and leading to structurally diverse value-added sultine products. The process utilizes readily available substrates using inexpensive 5% benzoyl peroxide (BPO) as an initiator to generate functionalized sultines with broad functional group tolerance in medium to excellent yields in a highly atom-economical manner. In addition, … Show more
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