Thermohypersensitive polydiacetylene vesicles embedded in calcium-alginate hydrogel beads

Song, Seoyoon; Jang, Huisoo; Jeong, Woojin; Shim, Jiwook; Kim, Sun Min; Jeon, Tae‐Joon

doi:10.1007/s11814-022-1306-x

Korean J. Chem. Eng.

2023

DOI: 10.1007/s11814-022-1306-x

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Thermohypersensitive polydiacetylene vesicles embedded in calcium-alginate hydrogel beads

Seoyoon Song

Huisoo Jang

Woojin Jeong

et al.

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“…Polydiacetylene (PDA) is one of the most frequently used sensing molecules for POC testing because of its unique chromogenic behaviors upon exposure to various stimuli, ,, including bacteria. − Upon detection, the blue-phase PDA turns red, allowing for detection by the naked eye. Moreover, further applications become possible when incorporating PDA vesicles into hydrogel matrixes, , which immobilizes the sensing molecules within the hydrogel matrix.…”

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Portable Colorimetric Hydrogel Beads for Point-of-Care Antimicrobial Susceptibility Testing

Song,

Jang,

Lee

et al. 2023

ACS Sens.

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Sepsis is a life-threatening condition with systemic inflammatory responses caused by bacterial infections. Considering the emergence of antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA), sepsis is a great threat to public health. The gold standard methods for antimicrobial susceptibility testing (AST), however, take at least approximately 3 days to implement the entire blood culture, pure culture, and AST processes. To overcome the time-consuming nature of conventional AST, a method employing a chromatic biosensor composed of poly(diacetylene), alginate, and LB broth (PAL) is introduced in this study. Compared to the gold standards, AST with PAL biosensors can be completed within a time frame as short as 16 h. Such a significant reduction in time is possible because the consecutive cultures and AST are carried out simultaneously by encapsulating the bacterial nutrients and detection molecules into a single component. The bead-like hydrogel sensors were used in their freeze-dried form, which endows them with portability and stability, thus making them adequate for point-of-care testing. The PAL biosensor yields minimum inhibitory concentrations comparable to those from the Clinical and Laboratory Standards Institute, and the applicability of the biosensor is further shown in MRSA-infected mice.

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confidence: 99%

Portable Colorimetric Hydrogel Beads for Point-of-Care Antimicrobial Susceptibility Testing

Song,

Jang,

Lee

et al. 2023

ACS Sens.

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Thermohypersensitive polydiacetylene vesicles embedded in calcium-alginate hydrogel beads

Cited by 1 publication

References 35 publications

Portable Colorimetric Hydrogel Beads for Point-of-Care Antimicrobial Susceptibility Testing

Portable Colorimetric Hydrogel Beads for Point-of-Care Antimicrobial Susceptibility Testing

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