Thermography in the stroke rehabilitation

Hegedüs, Botond; Hegedűs, Szilvia; Gálfi, Márta

doi:10.21611/qirt.2016.163

Cited by 1 publication

(3 citation statements)

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“…205 Examples of these metal-mediated reactions include the related Ullmann coupling, 206 Goldberg reaction, 120,[207][208][209] and Chan-Lam-Evans coupling, 110,150,[210][211][212] as well as the prototypical cross-coupling reaction for the generation of sp 2 C-N bonds, the Buchwald-Hartwig amination. [213][214][215][216][217][218] Another metal-mediated reaction, the aza-Wacker reaction, reported by Hegedus beginning in 1976, [219][220][221][222] generates sp 3 C-N bonds. Asymmetric variants [223][224] have been developed and detailed mechanistic studies of the aza-Wacker reaction have been conducted.…”

Section: Introductionmentioning

confidence: 99%

“…292 Shorter reaction times, lower reaction temperature, and limited side product formation could be achieved via a simple oxidation of the amine using a combination of benzoyl peroxide and an inorganic base in DMF. This method allowed expedient syntheses of a host of mono-and disubstituted O-benzoylhydroxylamines (219). Good to excellent yields were obtained when coupling with organozinc reagents for over twenty different coupled products including the sterically demanding coupling to form 245, albeit in modest yield (Figure 55).…”

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confidence: 99%

“…In 2013, Miura published a copper-catalyzed amination of arylsilanes using O-benzoylhydroxylamines (219) to generate anilines. 296 The optimized arylsilane was [(2hydroxymethyl)-phenyl]dimethylphenylsilane 269, originally developed by Nakao and Hiyama, which forms the pentacoordinated arylsilicate in situ.…”

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confidence: 99%

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Cross-Coupling of Heteroatomic Electrophiles

2019

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At the advent of cross-coupling chemistry, carbon electrophiles based on halides or psuedohalides were the only suitable electrophilic coupling partners. Almost two decades passed before the first cross-coupling reaction of heteroatom-based electrophiles was reported. Early work by Murai and Tanaka initiated investigations into silicon electrophiles. Narasaka and Johnson pioneered the way in the use of nitrogen electrophiles; while Suginome began the exploration of boron electrophiles. The chemistry reviewed within provides prospective on the use of heteroatomic electrophiles specifically silicon-, nitrogen-, boron-, oxygen-and phosphorus-based electrophiles in transitionmetal catalyzed cross-coupling. For the purposes of this review, a loose definition of crosscoupling is utilized; all reactions minimally proceed via an oxidative addition event. Although not cross-coupling in a traditional sense, we have also included catalyzed reactions that join a heteroatomic electrophile with an in situ generated nu-cleophile. However, for brevity, those involving hydroamination or C-H activation as a key step are largely excluded. This work includes primary references published up to and including October 2018.

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