Thermogenic effect of two β-adrenoceptor blocking drugs, propranolol and carvedilol, on skeletal muscle in rats. A microcalorimetric study

Fagher, Birger; Monti, Mario

doi:10.1016/0040-6031(94)02010-l

Cited by 9 publications

(3 citation statements)

References 33 publications

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“…To assess whether stimulation of the nerve was optogenetic in nature and not driven by optically-induced heating of the nerve, an optical model of the Pennes bioheat equation provided in the Matlab package by Stujenske et al was adapted for the peripheral nerve anatomy and tissue properties [20,21]. In addition to the MC output and tissue-specific µ a , other inputs to the thermal model included tissue density, heat capacity, thermal conductivity, perfusion rate, and metabolic generation for rat tissue gathered from the literature (supplemental figure 1(C) stacks.iop.org/JNE/14/034002/mmedia) [22][23][24][25][26].…”

Section: Methodsmentioning

confidence: 99%

Transdermal optogenetic peripheral nerve stimulation

et al. 2017

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Section: Methodsmentioning

confidence: 99%

Transdermal optogenetic peripheral nerve stimulation

et al. 2017

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“…It was shown that muscle biopsied from a patient who had received propanolol for one week had a lower thermogenesis as well as a lower isokinetic endurance [63]. Similarly later studies obtained analogous results in human and animal models and emphasized the differences between propanolol and other drugs such as terbutaline [64] and carvedilol [65]. …”

Section: Biomedical Applications Of Imcmentioning

confidence: 99%

Biomedical Use of Isothermal Microcalorimeters

Braissant

Wirz

Göpfert

et al. 2010

Sensors

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Isothermal microcalorimetry is becoming widely used for monitoring biological activities in vitro. Microcalorimeters are now able to measure heat production rates of less than a microwatt. As a result, metabolism and growth of relatively small numbers of cultured bacteria, protozoans, human cells and even small animals can be monitored continuously and extremely accurately at any chosen temperature. Dynamic effects on these organisms of changes in the culture environment—or of additions to it—are easily assessed over periods from hours to days. In addition microcalorimetry is a non-destructive method that does not require much sample preparation. It is also completely passive and thus allows subsequent evaluations of any kind on the undisturbed sample. In this review, we present a basic description of current microcalorimetry instruments and an overview of their use for various biomedical applications. These include detecting infections, evaluating effects of pharmaceutical or antimicrobial agents on cells, monitoring growth of cells harvested for tissue eingineering, and assessing medical and surgical device material physico-chemical stability and cellular biocompatibility.

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“…This drug protects against the damages in the skeletal muscle myofibrils due to oxidation in patients with heart failure [14]. The thermogenic effect of carvedilol on the skeletal muscle in rats has been shown previously by microcalorimetry [26]. Carvedilol reduces skeletal muscle necrosis in ischemic states [27].…”

Section: Carvedilol Effectsmentioning

confidence: 85%

Carvedilol: A Promising Drug Combined With Lipid-lowering Medications for Patients With Hypertension and Heart Failure

Zabihi

Askarian

Moghaddam

et al. 2020

IJT

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Background: Statins frequently cause myopathy especially in combination with fibrates, and physical activity is considered a trigger for the muscle disorder. Elevated plasma levels of creatine kinase (CK), lactate dehydrogenase (LDH) and aldolase, are the main indicators of the severity of myopathy. Carvedilol is commonly used with lipid-lowering drugs in the management of heart failure, hypertension and dyslipidemia. It is not yet clear whether carvedilol, an alpha and β blocker, and anti-oxidant, may influence the development of myopathy when combined with statins and fibrates in cardiac patients. Methods: In this animal experiment, a 10 days regimen containing oral atorvastatin and gemfibrozil at doses of 80 and 1000 mg/kg/day, respectively, was used to induce myopathy in rats. The animals were forced to swim in a pool on days 8, 9 and 10 into the study. Carvedilol (2.5 mg/kg/day) was added to atorvastatin and gemfibrozil during the 10-day study period, in addition to the exercise protocol given to the treatment groups only. The mean of swimming tolerance times and the serum levels of CK, LDH and aldolase were measured at the completion of the study. Results: Carvedilol did not significantly alter the swimming tolerance time or the plasma levels of CK, LDH and aldolase in the rats receiving ATV, GMF and carvedilol plus the exercise protocol, compared with those that did not receive carvedilol (P>0.05). Conclusion: Carvedilol may be used in combination with lipid-lowering drug in the management of patients with heart failure and hypertension, pending its safety approval by clinical studies in humans.

show abstract

Thermogenic effect of two β-adrenoceptor blocking drugs, propranolol and carvedilol, on skeletal muscle in rats. A microcalorimetric study

Cited by 9 publications

References 33 publications

Transdermal optogenetic peripheral nerve stimulation

Transdermal optogenetic peripheral nerve stimulation

Biomedical Use of Isothermal Microcalorimeters

Carvedilol: A Promising Drug Combined With Lipid-lowering Medications for Patients With Hypertension and Heart Failure

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