Thermogelling Polymer–Platinum(IV) Conjugates for Long-Term Delivery of Cisplatin

Shen, Wen; Luan, Jiabin; Cao, Liqin; Sun, Jian; Yu, Lin; Ding, Jiandong

doi:10.1021/bm501220a

Cited by 97 publications

(57 citation statements)

References 60 publications

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“…483 These conjugates formed micelles in aqueous solution that were observed to undergo a thermoreversible sol-gel transition, forming hydrogels at 37 °C. These semi-solids were capable of releasing platinum in a controlled fashion, without an initial burst, over the course of two months.…”

Section: Nanodelivery Of Platinum(iv) Complexesmentioning

confidence: 99%

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

2016

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The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,, but new platinum agents have been very slow to enter the clinic. Recently, however, there has been a surge of activity, based on a great deal of mechanistic information, aimed at developing non-classical platinum complexes that operate via mechanisms of action distinct from those of the approved drugs. The use of nanodelivery devices has also grown and many different strategies have been explored to incorporate platinum warheads into nanomedicine constructs. In this review, we discuss these efforts to create the next generation of platinum anticancer drugs. The introduction provides the reader with a brief overview of the use, development, and mechanism of action of the approved platinum drugs to provide the context in which more recent research has flourished. We then describe approaches that explore non-classical platinum(II) complexes with trans geometry and with a monofunctional coordination mode, polynuclear platinum(II) compounds, platinum(IV) prodrugs, dual-treat agents, and photoactivatable platinum(IV) complexes. Nanodelivery particles designed to deliver platinum(IV) complexes will also be discussed, including carbon nanotubes, carbon nanoparticles, gold nanoparticles, quantum dots, upconversion nanoparticles, and polymeric micelles. Additional nanoformulations including supramolecular self-assembled structures, proteins, peptides, metal-organic frameworks, and coordination polymers will then be described. Finally, the significant clinical progress made by nanoparticle formulations of platinum(II) agents will be reviewed. We anticipate that such a synthesis of disparate research efforts will not only help to generate new drug development ideas and strategies, but also reflect our optimism that the next generation of platinum cancer drugs is about to arrive.

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Section: Nanodelivery Of Platinum(iv) Complexesmentioning

confidence: 99%

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

2016

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“…These thermogels are classified as a group of soft materials which assemble due to supramolecular interactions of the polymeric blocks present . At low temperatures, the aqueous polymeric solution or sol state exists as fluids with low viscosity . When the temperature is elevated, close to body temperature, there exist a sol to gel transition where by the polymeric fluids solidifies into a hydrogel.…”

Section: Introductionmentioning

confidence: 99%

New Poly[(R )-3-hydroxybutyrate-co -4-hydroxybutyrate] (P3HB4HB)-Based Thermogels

Wee

Liow

Liu

et al. 2017

Macromol. Chem. Phys.

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Poly[(R)‐3‐hydroxybutyrate] (P3HB) is a potential candidate for biomaterials due to its biocompatibility and biodegradability. However, P3HB needs to have tunable hydrophobicity, modification through chemical functionalization and the right hydrolytic stability to increase their potential for water‐based biomedical applications such as using them as in situ forming gels for drug delivery. This work focuses on using a copolymer, poly[(R)‐3‐hydroxybutyrate‐co‐4‐hydroxybutyrate] (P3HB4HB) in a thermogelling multiblock system with polypropylene glycol and polyethylene glycol to study the effect of the hydrophobic P3HB4HB on gelation properties, degradation, and drug release rates with reference to P3HB. Thermogels containing P3HB4HB segments show lower critical micellization concentration values in a range from 3 × 10−4 to 1.08 × 10−3 g mL−1 and lower critical gelation concentration values ranging from 2 to 6 wt% than that of gels containing P3HB. Furthermore, gels containing P3HB4HB degrade at a slower rate than the gels containing P3HB. Drug release studies of 5 µg mL−1 of doxorubicin show that gels containing P3HB4HB exhibit sustained release although the release rates are faster than gels containing P3HB. However, this can be modified by varying the concentration of the gels used. Process optimization of purifying the starting material is one important factor before the synthesis of these biomaterials.

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“…Recently, biodegradable thermogelling hydrogels which undergo a reversible sol-gel transition upon heating to body temperature have gained increased attention as a minimally invasive depot system for drug delivery, tissue engineering, etc. [16][17][18][19][20][21][22]. Chemical drugs, bioactive macromolecules, and even cells can be incorporated into the polymer aqueous solution at low or room temperature.…”

Section: Introductionmentioning

confidence: 99%

Sustained intravitreal delivery of dexamethasone using an injectable and biodegradable thermogel

et al. 2015

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Thermogelling Polymer–Platinum(IV) Conjugates for Long-Term Delivery of Cisplatin

Cited by 97 publications

References 60 publications

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

New Poly[(R )-3-hydroxybutyrate-co -4-hydroxybutyrate] (P3HB4HB)-Based Thermogels

Sustained intravitreal delivery of dexamethasone using an injectable and biodegradable thermogel

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