Thermodynamics of the solubility of 4-acetylbenzoic acid in different solvents from 303.15 to 473.15K

Sunsandee, Niti; Hronec, Milan; Štolcová, Magdaléna; Leepipatpiboon, Natchanun; Pancharoen, Ura

doi:10.1016/j.molliq.2013.01.023

Cited by 95 publications

(79 citation statements)

References 48 publications

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“…The mole fraction solubility of GLZ against mass fraction of Transcutol (w = 0.0 to 1.0) in Transcutol-water co-solvent mixtures was determined by shake flask method at various temperatures (298.15 to 333.15) K. 15,17,18 The excess amount of GLZ was added in 5 g of each co-solvents mixture including pure water (w = 0.0) and pure Transcutol (w = 1.0) in 10 ml capacity vials in triplicate to obtain drug suspensions. Each vial was tightly closed.…”

Section: Measurement Of Glz Solubilitymentioning

confidence: 99%

“…These experiments were carried out at different temperatures (298.15 to 333.15) K. After the period of 72 h, all drug suspensions were taken out from the shaker bath and allowed to settle drug particles for the period of 2 h at the bottom of the vials. 18,26 All the drug suspensions were filtered using 0.45 µm filter paper, supernatant from each sample was taken and diluted 1000 times with respective solvent/cosolvent mixture and subjected for analysis of GLZ content at the wavelength of 227 nm using UV-Visible spectrophotometer (SP1900, Axiom, Germany). 1,7 The proposed analytical method was found to be linear in the range of (2 to 50) µg /g with correlation coefficient (R 2 ) of 0.999.…”

Section: Measurement Of Glz Solubilitymentioning

confidence: 99%

“…15,18,26 According to this model, the mole fraction solubility of solute is temperature-dependent which can be represented by equation 2 to describe solid-liquid equilibrium:…”

Section: Thermodynamic Modeling Of Glz Solubilitymentioning

confidence: 99%

“…According to the thermodynamic principles, the dissolution of GLZ (solute) into a liquid can be expressed as: 17,18,31 Solid + liquid = solid-liquid at the equilibrium The standard molar enthalpy ( H  o ) and entropy ( S  o ) of GLZ dissolution can be calculated using equations 4 and 5, respectively: Where, R and T represent the universal gas constant and absolute temperature (expressed in K), respectively. .…”

Section: Thermodynamic Parameters For Glz Dissolutionmentioning

confidence: 99%

“…Molecular structure of GLZ physicochemical properties of the drugs because of its wide range of applications such as drug crystallization/purification, drug dissolution/permeation, prefo rmulation studies and formulation development. [15][16][17][18] Therefore, solubility data of poorly soluble drugs must be determined in wide range of temperatures to get complete information about physicochemical characterization of drugs. 19 The IUPAC name of Transcutol is diethylene glycol monoethyl ether which has been investigated as a cosurfactant in the preparation and characterization of several lipid based formulations such as nanoemulsions/microemulsions and self-nanoemulsifying (SNEDDS)/self-microemulsifying (SMEDDS) drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

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Solubility of Gliclazide in Transcutol + Water Co-solvent Mixtures at (298.15 to 333.15) K

2014

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Abstract. The aim of present investigation was to determine the mole fraction solubility of a poorly water soluble antidiabetic drug gliclazide (GLZ) in mono-solvents and various Transcutol + water co-solvent mixtures at (298.15 to 333.15) K. The experimental solubility of GLZ was measured by shake flask method and resulting data was correlated with the modified Apelblat model at each temperature studied. Good correlation was observed between the experimental data of GLZ and calculated one with absolute relative deviation in the range of (0.050 to 5.680) %. The correlation coefficients were observed in the range of 0.9966 to 0.9995 which indicated good fitting of experimental solubility data. The lowest mole fraction solubility of GLZ was observed in pure water (1.9 × 10 -6 at 298.15 K) whereas the highest one was observed in pure Transcutol (11.9 × 10 -3 at 298.15 K). The enthalpies and entropies for GLZ dissolution were observed as positive values in the range of (15.742 to 40.551) kJ mol -1 and (52.801 to 121.721) J mol -1 K -1 , respectively in all sample matrices. These results of thermodynamic parameters indicated that the dissolution of GLZ is endothermic and an entropy-driven process. Based on current solubility data, GLZ was considered as practically insoluble (poorly soluble) in pure water and soluble in Transcutol. These preliminary studies indicated that Transcutol could be used as a co-solvent for solubility enhancement of GLZ which could help in preformulation studies and formulation development of GLZ.

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Section: Measurement Of Glz Solubilitymentioning

confidence: 99%

Section: Measurement Of Glz Solubilitymentioning

confidence: 99%

“…15,18,26 According to this model, the mole fraction solubility of solute is temperature-dependent which can be represented by equation 2 to describe solid-liquid equilibrium:…”

Section: Thermodynamic Modeling Of Glz Solubilitymentioning

confidence: 99%

Section: Thermodynamic Parameters For Glz Dissolutionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Solubility of Gliclazide in Transcutol + Water Co-solvent Mixtures at (298.15 to 333.15) K

2014

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Solubility and Solution Thermodynamic Properties of 4-(4-Hydroxyphenyl)-2-butanone (Raspberry Ketone) in Different Pure Solvents

et al. 2017

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Solution thermodynamics and solubility prediction of glibenclamide in Transcutol + water co-solvent mixtures at 298.15–333.15 K

2013

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Solution thermodynamics and solubility of glibenclamide (GBN) in binary co-solvent mixtures of Transcutol + water at temperature range of 298.15-333.15 K were investigated in present study. The modified Apelblat model was used to predict the solubility of GBN in co-solvent mixtures at various temperatures. The highest and lowest solubility of GBN were observed in pure Transcutol and pure water, respectively. Moreover, all co-solvent mixtures had highest solubility at 333.15 K. The experimental solubility data of GBN was correlated well with the modified Apelblat model at each temperature studied with relative absolute deviation in the range of 0.008-5.903 %. The correlation coefficients in co-solvent mixtures were observed in the range of 0.995-0.999 which indicated good fitting of experimental data with calculated one. The enthalpies and entropies for GBN dissolution were observed in the range of 2.012-38.215 kJ mol(-1) and 6.748-114.709 J mol(-1) K(-1), respectively indicating its dissolution is endothermic and an entropy-driven process. These results indicated that Transcutol can be used as a co-solvent in preformulation studies and formulation development of GBN.

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Thermodynamics of the solubility of 4-acetylbenzoic acid in different solvents from 303.15 to 473.15K

Cited by 95 publications

References 48 publications

Solubility of Gliclazide in Transcutol + Water Co-solvent Mixtures at (298.15 to 333.15) K

Solubility of Gliclazide in Transcutol + Water Co-solvent Mixtures at (298.15 to 333.15) K

Solubility and Solution Thermodynamic Properties of 4-(4-Hydroxyphenyl)-2-butanone (Raspberry Ketone) in Different Pure Solvents

Solution thermodynamics and solubility prediction of glibenclamide in Transcutol + water co-solvent mixtures at 298.15–333.15 K

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