Thermodynamics of the solubility of reserpine in {{2-(2-ethoxyethoxy)ethanol + water}} mixed solvent systems at different temperatures

Solubility and thermodynamics of vanillin in Carbitol-water mixtures at different temperatures

“…The influence of mass fraction of Carbitol on solubility of vanillin at T = 298.15-318.15 K and p = 0.1 MPa was also investigated as shown in Figure 4. From Figure 4, it was observed that the solubility of vanillin was found to be increasing with increase in mass fraction of Carbitol in Carbitolwater mixtures at T = 298.15-318.15 K. The results of this work were in good agreement with previously published solubility data of other bioactive compounds such as isatin and reserpine in Carbitol-water mixtures at T = 298.15-338.15 K and p = 0.1 MPa and silymarin in PEG 400-water mixtures at T = 298.15-333.15 K and p = 0.1 MPa (Shakeel and Anwer, 2015;Shakeel et al, 2015bShakeel et al, , 2015c. Based on these results, vanillin has been considered as soluble in water and freely soluble in Carbitol according to USP and BP classification of solubility (Shakeel et al, 2015a).…”

“…In the present work, the solubility of vanillin in water and Carbitol at T = 298.15 K was found to be 1.23 × 10 -3 and 2.37 × 10 -1 , respectively. These results indicated good agreement of Carbitol as compared to pure water (Shakeel et al, 2015b(Shakeel et al, , 2015c. The influence of mass fraction of Carbitol on solubility of vanillin at T = 298.15-318.15 K and p = 0.1 MPa was also investigated as shown in Figure 4.…”

“…The solubility and thermodynamic data of bioactive compounds such as vanillin in water-cosolvent mixtures are extremely useful in extraction of these bioactive compounds from their respective plant source, purification/isolation, crystallization and preformulation studies/formulation development of these compounds (Chen et al, 2014;Shakeel and Anwer, 2015;Shakeel et al, 2015bShakeel et al, , 2015c. Recently, Carbitol has been investigated as a potential cosolvent in solubility enhancement of bioactive compounds such as isatin and reserpine in literature (Shakeel et al, 2015b(Shakeel et al, , 2015c(Shakeel et al, , 2015d. Various semiempirical solubility models are used to validate experimental solubilities of bioactive compounds and to correlate these data with calculated solubilities.…”

Solution thermodynamics of creatine monohydrate in binary (water + ethanol) solvent systems at T = (278.15 to 328.15) K

“…It has been demonstrated that the modified van't Hoff equation (Eq. (5)) can be successfully applied in the correlation of the solubility in the pure solvent [26,27]. For the system in this work, the solubility of creatine monohydrate in water and ethanol is presented as Eqs.…”

Solution thermodynamics of simvastatin in pure solvents and binary solvent mixtures

“…The poor aqueous solubility of pharmaceuticals is a main barrier for their formulation development [6,7]. Solubility of pharmaceuticals is an extremely useful physicochemical property, and indispensable for designing and optimization of crystallization process.…”