Thermodynamics of micellization of tapered statistical copolymers of ethylene oxide and propylene oxide in water

Kelarakis, Antonios; Mai, Sebastian; Havredaki, Vasiliki; Brett, Alison; Booth, Colin

doi:10.1016/j.jcis.2004.03.004

Cited by 14 publications

(12 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results are consistent with earlier studies showing that there is an equilibrium between unimers and aggregates in a solution containing 4‐arm star block copolymer, sP(EO‐block‐PO) . In addition, our results are supported by studies showing that both linear block copolymers and linear gradient copolymers of EO and PO undergo self‐assembly …”

Section: Resultssupporting

confidence: 92%

Reactive Self‐Assembly and Specific Cellular Delivery of NCO‐sP(EO‐stat‐PO)‐Derived Nanogels

Hildebrandt

Paloheimo

Mäntylä

et al. 2018

Macromolecular Bioscience

View full text Add to dashboard Cite

This study presents the reactive self-assembly of isocyanate functional and amphiphilic six-arm, star-shaped polyether prepolymers in water into nanogels. Intrinsic molecular amphiphilicity, mainly driven by the isophorone moiety at the distal endings of the star-shaped molecules, allows for the preparation of spherical particles with an adjustable size of 100-200 nm by self-assembly and subsequent covalent cross-linking without the need for organic solvents or surfactants. Covalent attachment of a fluorescence dye and either the cell-penetrating TAT peptide or a random control peptide sequence shows that only TAT-labeled nanogels are internalized by HeLa cells. The nanogels thus specifically enter the cells and accumulate in the perinuclear area in a time- and concentration-dependent manner.

show abstract

Section: Resultssupporting

confidence: 92%

Reactive Self‐Assembly and Specific Cellular Delivery of NCO‐sP(EO‐stat‐PO)‐Derived Nanogels

Hildebrandt

Paloheimo

Mäntylä

et al. 2018

Macromolecular Bioscience

View full text Add to dashboard Cite

show abstract

“…The A series of peaks also suggest that this is the case. In addition, peaks from this series indicate that the EO is the first monomer feed added to the initiator, as losses of part of the initiator (E 3 P 4 ) and the initiator and EO units (E 2 P 4 , EP 4 and P 4 ) are part of this series. This series also suggests that there is a run of PO units in this oligomer (i.e., peaks annotated as P 2 , P 3 and P 4 in Fig.…”

Section: Tandem Mass Spectrometry Of Copolymersmentioning

confidence: 98%

“…The initiator was a mixture of tridecanol and pentadecanol, which leads to formation of oligomers with tridecyl and pentadecyl initiating (␣) end groups (R). RO Spectroscopic approaches such as infra-red (IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy have been used to characterise these polymer systems [2][3][4][5][6][7][8]. These approaches measure overall average values rather than individual molecular structure.…”

Section: Introductionmentioning

confidence: 99%

Microstructural and conformational studies of polyether copolymers

Jackson

Scrivens

Williams

et al. 2004

International Journal of Mass Spectrometry

View full text Add to dashboard Cite

“…The dye solubilization technique has been widely used to study the micellar behavior of surfactants (Mitra and Dungan, 2000;Mata et al, 2004Mata et al, , 2005, amphiphilic block copolymers (Bhattarai et al, 2003;Kelarakis et al, 2004), and amphiphilic drugs (Kim and Shah, 2002). The solubilization of a water-insoluble dye depends on the state of aggregation of surfactants.…”

Section: Introductionmentioning

confidence: 99%

Cloud Point and Dye Solubilization Studies of Amphiphilic Drug Solutions: The Effect of Electrolytes and Nonelectrolytes

Kim

Yoo

et al. 2006

Chemical Engineering Communications

View full text Add to dashboard Cite

The effect of electrolytes and nonelectrolytes on the micellar behavior of amitriptyline (AMT), an amphiphilic drug, has been investigated using cloud point (CP) and dye solubilization techniques. The critical micelle concentration (cmc) of AMT determined by the Wilhelmy plate method was about 40 mM in the presence of 10 mM sodium phosphate, and it reduced to about 20 mM in the presence of 500 mM sodium phosphate. Interestingly, the CP phenomenon was observed even below the cmc in cationic AMT solutions. Increasing AMT concentration reduced the CP below the cmc, while it had the opposite effect above the cmc. An increase in the pH of the AMT solutions from 6.2 to 6.8 at a given AMT concentration decreased the CP and increased the AMT micellar size. Addition of an electrolyte such as sodium chloride to 100 mM AMT in water increased both the CP and the AMT micellar size. On the other hand, added nonelectrolytes such as dextrose, sucrose, and urea decreased both the CP and the micellar size. Experimental results have been interpreted in terms of electrostatic effect and interactions between additives and AMT head groups.

show abstract

Thermodynamics of micellization of tapered statistical copolymers of ethylene oxide and propylene oxide in water

Cited by 14 publications

References 18 publications

Reactive Self‐Assembly and Specific Cellular Delivery of NCO‐sP(EO‐stat‐PO)‐Derived Nanogels

Reactive Self‐Assembly and Specific Cellular Delivery of NCO‐sP(EO‐stat‐PO)‐Derived Nanogels

Microstructural and conformational studies of polyether copolymers

Cloud Point and Dye Solubilization Studies of Amphiphilic Drug Solutions: The Effect of Electrolytes and Nonelectrolytes

Contact Info

Product

Resources

About