Thermodynamics of complexation of magnesium and calcium ions with dichloromethylenediphosphonate

Kaila, L.; Lajunen, Lauri H. J.; Rizkalla, Ε. N.; Eloranta, Jussi

doi:10.1016/0039-9140(93)80157-m

Cited by 2 publications

(2 citation statements)

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“…[59] Within this group, the greatest number of studies have been devoted to etidronate [42,[66][67][68][69][70][71][72][73][74] and clodronate. [67,69,[75][76][77][78][79] Others, such as pamidronate, [59,72,80] alendronate, [59,72,81] tiludronate, [82] or zolendronate [83,84] have been discussed in only af ew research papers. To the best of the author's knowledge,o riginal data for risedronate and ibandronate directly binding to Ca 2 + are not available to date.…”

Section: Introductionmentioning

confidence: 99%

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Interactions between Clinically Used Bisphosphonates and Bone Mineral: from Coordination Chemistry to Biomedical Applications and Beyond

Gałęzowska

2018

ChemMedChem

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Bisphosphonates (BPs) are well-established, widely used first-choice drugs for bone-related diseases and are one of the few classes of molecules for selective bone targeting. Their binding to calcium cations within hydroxyapatite (HA) is a key physicochemical event that takes place on the bone surface. It is the starting point for a cascade of biochemical reactions and cellular effects that lead to the pharmacological activity of BPs. The phenomenon has been known for years, yet its physicochemical nature is still not fully understood. In particular, the adsorption/release processes and structure-function relationships of BPs remain to be clarified. These are elementary, yet crucial factors, which should influence the design and development of new delivery tools or drugs with improved characteristics. This review summarizes the current understanding of the chemical interactions between clinically used BPs and bone mineral, starting from basic Ca coordination chemistry through to interactions with hydroxyapatite, nanocrystalline apatites, and natural bone mineral.

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Section: Introductionmentioning

confidence: 99%

“…However, only few of them focus on clinically relevant BPs . Within this group, the greatest number of studies have been devoted to etidronate and clodronate . Others, such as pamidronate, alendronate, tiludronate, or zolendronate have been discussed in only a few research papers.…”

Section: Introductionmentioning

confidence: 99%

Interactions between Clinically Used Bisphosphonates and Bone Mineral: from Coordination Chemistry to Biomedical Applications and Beyond

Gałęzowska

2018

ChemMedChem

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Nanotechnologies and controlled release formulations for the administration of bisphosphonates and their potential in radiation protection

Landon,

Phan,

Fay

et al. 2023

Journal of Drug Delivery Science and Technology

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Thermodynamics of complexation of magnesium and calcium ions with dichloromethylenediphosphonate

Cited by 2 publications

References 13 publications

Interactions between Clinically Used Bisphosphonates and Bone Mineral: from Coordination Chemistry to Biomedical Applications and Beyond

Interactions between Clinically Used Bisphosphonates and Bone Mineral: from Coordination Chemistry to Biomedical Applications and Beyond

Nanotechnologies and controlled release formulations for the administration of bisphosphonates and their potential in radiation protection

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