Thermodynamics of complexation of aqueous 18-crown-6 with potassium ion: apparent molar volumes and apparent molar heat capacities of aqueous 18-crown-6 and of the (18-crown-6+potassium chloride) complex at temperatures (278.15 to 393.15) K, at molalities (0.02 to 0.3) mol·kg−1, and at the pressure 0.35 MPa

Niederhauser, T.L.; Brown, B.R.; Ziemer, Sabine; Sargent, J.D.; Woolley, Earl M.

doi:10.1016/j.jct.2004.07.027

Cited by 11 publications

(3 citation statements)

References 35 publications

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“…Larger deviations from data by Kolhapurkar et al are observed in the entire temperature range. Smoothed values calculated from the equation presented by Niederhauser et al agree, with the exception of the lowest temperatures, with our values within the estimated experimental uncertainties, the deviations are positive in the low temperature range and negative at higher temperatures. The effect of the difference in experimental pressure is, in regard to uncertainties of Niederhauser measurements, negligible.…”

Section: Discussionsupporting

confidence: 90%

“…Smoothed values calculated from the equation presented by Niederhauser et al agree, with the exception of the lowest temperatures, with our values within the estimated experimental uncertainties, the deviations are positive in the low temperature range and negative at higher temperatures. The effect of the difference in experimental pressure is, in regard to uncertainties of Niederhauser measurements, negligible. Literature values of standard molar volume at T = 298.15 K cover rather large interval 2 cm 3 ·mol –1 wide.…”

Section: Discussionsupporting

confidence: 90%

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Partial Molar Volumes and Partial Molar Isentropic Compressions of 15-Crown-5 and 18-Crown-6 Ethers at Infinite Dilution in Water at Temperatures T = (278 to 343) K and Atmospheric Pressure

Cibulka

2014

J. Chem. Eng. Data

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Density and speed of sound data for dilute aqueous solutions of two crown ethers, 15-crown-5 and 18crown-6, were measured using the Anton Paar DSA 5000 vibrating-tube densimeter and sound analyzer in the temperature range from (278.15 to 343.15) K and at atmospheric pressure. Standard molar volumes and standard molar isentropic compressions were evaluated from the measured data. Present data were combined with those obtained previously for lower cyclic ethers, and the predictions of standard molar volumes and standard molar isentropic compressions based on a group contribution approach were tested and analyzed.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Partial Molar Volumes and Partial Molar Isentropic Compressions of 15-Crown-5 and 18-Crown-6 Ethers at Infinite Dilution in Water at Temperatures T = (278 to 343) K and Atmospheric Pressure

Cibulka

2014

J. Chem. Eng. Data

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“…For comparison, the enthalpy of binding of potassium to crown ethers has been measured at around 3–4 kcal mol −1 ( 211 , 212 ). The value of Δ G (310) for potassium binding to 18-6 crown ethers in aqueous solution was measured at around 2.5 kcal mol −1 ion ( 211 , 213 ), and as expected a somewhat more favorable 3.1 kcal mol −1 in organic solvents ( 212 , 214 ). This includes the energy of desolvation and conformational rearrangement of the crown ether on complexation, but is a rough model for the binding of a single K + to a preformed quadruplex.…”

Section: Ion Binding and Solvationsupporting

confidence: 61%

Stability and kinetics of G-quadruplex structures

Lane

Chaires

Gray

et al. 2008

Nucleic Acids Research

660

763

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In this review, we give an overview of recent literature on the structure and stability of unimolecular G-rich quadruplex structures that are relevant to drug design and for in vivo function. The unifying theme in this review is energetics. The thermodynamic stability of quadruplexes has not been studied in the same detail as DNA and RNA duplexes, and there are important differences in the balance of forces between these classes of folded oligonucleotides. We provide an overview of the principles of stability and where available the experimental data that report on these principles. Significant gaps in the literature have been identified, that should be filled by a systematic study of well-defined quadruplexes not only to provide the basic understanding of stability both for design purposes, but also as it relates to in vivo occurrence of quadruplexes. Techniques that are commonly applied to the determination of the structure, stability and folding are discussed in terms of information content and limitations. Quadruplex structures fold and unfold comparatively slowly, and DNA unwinding events associated with transcription and replication may be operating far from equilibrium. The kinetics of formation and resolution of quadruplexes, and methodologies are discussed in the context of stability and their possible biological occurrence.

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Role of Alkali Metal Ions in G-Quadruplex Nucleic Acid Structure and Stability

Largy

Mergny

Gabelica

2016

Metal Ions in Life Sciences

148

150

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G-quadruplexes are guanine-rich nucleic acids that fold by forming successive quartets of guanines (the G-tetrads), stabilized by intra-quartet hydrogen bonds, inter-quartet stacking, and cation coordination. This specific although highly polymorphic type of secondary structure deviates significantly from the classical B-DNA duplex. G-quadruplexes are detectable in human cells and are strongly suspected to be involved in a number of biological processes at the DNA and RNA levels. The vast structural polymorphism exhibited by G-quadruplexes, together with their putative biological relevance, makes them attractive therapeutic targets compared to canonical duplex DNA. This chapter focuses on the essential and specific coordination of alkali metal cations by G-quadruplex nucleic acids, and most notably on studies highlighting cation-dependent dissimilarities in their stability, structure, formation, and interconversion. Section 1 surveys G-quadruplex structures and their interactions with alkali metal ions while Section 2 presents analytical methods used to study G-quadruplexes. The influence of alkali cations on the stability, structure, and kinetics of formation of G-quadruplex structures of quadruplexes will be discussed in Sections 3 and 4. Section 5 focuses on the cation-induced interconversion of G-quadruplex structures. In Sections 3 to 5, we will particularly emphasize the comparisons between cations, most often K(+) and Na(+) because of their prevalence in the literature and in cells.

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Cited by 11 publications

References 35 publications

Partial Molar Volumes and Partial Molar Isentropic Compressions of 15-Crown-5 and 18-Crown-6 Ethers at Infinite Dilution in Water at Temperatures T = (278 to 343) K and Atmospheric Pressure

Partial Molar Volumes and Partial Molar Isentropic Compressions of 15-Crown-5 and 18-Crown-6 Ethers at Infinite Dilution in Water at Temperatures T = (278 to 343) K and Atmospheric Pressure

Stability and kinetics of G-quadruplex structures

Role of Alkali Metal Ions in G-Quadruplex Nucleic Acid Structure and Stability

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