Thermodynamics of complex formation reactions in non-aqueous solvents

Aliphatic Acetylenic Homocoupling Catalyzed by a Novel Combination of AgOTs−CuCl2−TMEDA and Its Application for the Solid-Phase Synthesis of Bis-benzo[b]furan-Linked 1,3-Diynes

“…As a result, only the starting substrate E 2 was recovered in each case. This demonstrates that CuCl 2 is required and its Cl - exchange with OTs - from AgOTs may not occur since a soluble enthalpy-driven Ag I −TMEDA complex may be formed in CH 2 Cl 2 ,8c which prevents AgCl precipitation.…”

“…Ag I could activate the terminal carbon−hydrogen bond by forming a π-complex with the triple bond 8a. However, there is no report regarding the role of Ag I in facilitating acetylene homocoupling.…”