Thermodynamics of aggregation of Tweens in the presence of diclofenac sodium

Mehta, S.K.; Bala, Neeru; Sharma, Shweta

doi:10.1016/j.colsurfa.2005.06.013

Cited by 12 publications

(6 citation statements)

References 28 publications

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“…DNa, being more ionic in nature, resides on the surface of the NLCs and is expected to be affected by the polarity of the local environment. A similar shi in the absorption maximum of DNa to higher wavelength has been reported by Mehta et al 66 Association of DNa with the polyoxyethylene moiety of Tween might have played a role in this regard. The drug molecules may become weakly intercalated on the surface of NLC.…”

Section: Spectroscopic Studiessupporting

confidence: 84%

“…UV-visible absorption spectra of DNa and IMC in different solvents and in NLC are shown in Fig. Similar shift in the absorption maximum of DNa to higher wavelength has been reported by Mehta et al 66 Association of DNa with the polyoxyethylene moiety of Tweens might have played a role in this regard. Dependence of absorption maxima (λ max ) on the dielectric constant of the medium are also shown in Fig.…”

Section: Spectroscopic Studiessupporting

confidence: 81%

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Effect of polymer charge on the formation and stability of anti-inflammatory drug loaded nanostructured lipid carriers: physicochemical approach

et al. 2015

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Proposed model of NSAID loaded and polymer coated NLC alongwith its dependence of size ( ), PDI ( ), release rate ( ) and absorption maxima ( ) as well as its morphology and antibacterial activity ARTICLE This journal is Nanostructured lipid carriers (NLCs), with potential drug delivery capabilities, were formulated using soylecthin (SLC), tristearin (TS) and palmitic acid (PA) in the absence and the presence of two antiinflammatory drugs, diclofenac sodium (DNa) and indomethacin (IMC). Tween 60 was used as stabilizer separetely in combination with sodium carboxymethyl cellulose (NaCMC, anionic), polyethylene glycol (PEG, nonionic) and N, N, dimethyl-N-dodecyl derivative of hydroxyethyl cellulose (LM200, cationic). Both DNa and IMC substantially decreased size and increased polydispersity index (PDI) of the NLCs. Hydrodynamic parameter, viz., size, zeta potential and polydispersity index as well as the thermal behaviour of the NLCs depended on the type and charge of the added polymers. Weak interactions between drug and lipid matrices in the bulk mixtures were established through FT-IR studies. NLC formulations exhibited lower entrapment efficiency and loading content in case of DNa compared to IMC due to the higher ionic nature of the former drug. Polymers influenced the entrapment efficiency and loading ability of the NLCs in case of both DNa and IMC. 85% of the entrapped DNa was released from the NLC, compared to 54% release in case of IMC; the drug release rate were higher for PEG and NaCMC coated systems. LM200 delayed the drug release process with respect to NaCMC and PEG. Both DNa and IMC loaded NLCs inhibited the growth of gram positive bacteria, Bacillus amyloliquefaciens. It was concluded that the physicochemical properties of NLCs could effectively be modified by using polymers; thus the biomimetic characteristics of lipids and architectural advantage of polymers can be combined to yield a superior drug delivery system.

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Section: Spectroscopic Studiessupporting

confidence: 84%

Section: Spectroscopic Studiessupporting

confidence: 81%

Effect of polymer charge on the formation and stability of anti-inflammatory drug loaded nanostructured lipid carriers: physicochemical approach

et al. 2015

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“…A number of investigations have been carried out in improving our understanding of the phenomenon of solubilization by surfactant solutions [36][37][38][39]. The main interest concerns the extent to which a particular compound can be solubilized in a given surfactant solution at a specified concentration.…”

Section: The Quenching Mechanismmentioning

confidence: 99%

Excited State Interaction of Laser Dyes and Silver Nanoparticles in Different Media

El-Sayed¹,

Gaber²

2012

ANP

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Quenching the fluorescence of the dyes 3-(4 '-dimethylaminophenyl)-1-(1H-pyrrol-2-yl)prop-2-en-1-one (DMAPrP), 3-(4 '-dimethylaminophenyl)-1-(2-furanyl)prop-2-en-1-one (DMAFP) and 3-(4 '-dimethylaminophenyl)-1-(2-thienyl)prop-2-en-1-one (DMATP) has been investigated in the presence of silver cation and silver nanoparticles in different media. The results of the quenching experiments were analyzed using Stern-Volmer equation. Quenching the fluorescence of the dyes decreased with increasing medium viscosity. The Stern-Volmer constant (K SV) values in the absence and presence of ethylene glycol show that the quenching efficiencies decrease as the medium viscosity increases indicating that the quenching process is a diffusion-controlled process, and this is consistent with a dynamic-type quenching.

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“…Keeping this in mind, it was planned to investigate the behavior of diclofenac sodium in the presence of different cyclodextrins via spectroscopic and conductivity techniques. The information obtained from conductivity studies have been correlated with the observations of spectroscopic studies [15][16][17][19][20][21]. The analysis of the results will provide an insight into the thermodynamics of DS:CD association.…”

Section: Introductionmentioning

confidence: 95%

Energetically favorable interactions between diclofenac sodium and cyclodextrin molecules in aqueous media

Mehta

Bhasin

Dham

2008

Journal of Colloid and Interface Science

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Thermodynamics of aggregation of Tweens in the presence of diclofenac sodium

Cited by 12 publications

References 28 publications

Effect of polymer charge on the formation and stability of anti-inflammatory drug loaded nanostructured lipid carriers: physicochemical approach

Effect of polymer charge on the formation and stability of anti-inflammatory drug loaded nanostructured lipid carriers: physicochemical approach

Excited State Interaction of Laser Dyes and Silver Nanoparticles in Different Media

Energetically favorable interactions between diclofenac sodium and cyclodextrin molecules in aqueous media

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