“…Similar design with the X biosensors enabled differentiation of single-base mutations with just a background-level signal triggered by a mismatched target, 29 a performance that cannot be achieved even by the most recent developments in the thermodynamics-based approaches. 44 Several recent studies have demonstrated impressive LOD, ranging from 2.8 to 10 fM, and even reaching up to 10 CFU mL −1 . These achievements were realized by utilizing DNA linear probes with biotin-labeled reporters, 45 microfluidic chip devices, 46 or nanocomposites based on molybdenum disulfide, 47 with detection times spanning between 80 minutes to 4 hours.…”
Section: Resultsmentioning
confidence: 99%
“…Similar design with the X biosensors enabled differentiation of single-base mutations with just a background-level signal triggered by a mismatched target, 29 a performance that cannot be achieved even by the most recent developments in the thermodynamics-based approaches. 44…”
DNA nanotechnology deals with the design of non-naturally occurring DNA nanostructures that can be used in biotechnology, medicine, and diagnostics. In this study, we introduced a nucleic acid five-way junction...
“…Similar design with the X biosensors enabled differentiation of single-base mutations with just a background-level signal triggered by a mismatched target, 29 a performance that cannot be achieved even by the most recent developments in the thermodynamics-based approaches. 44 Several recent studies have demonstrated impressive LOD, ranging from 2.8 to 10 fM, and even reaching up to 10 CFU mL −1 . These achievements were realized by utilizing DNA linear probes with biotin-labeled reporters, 45 microfluidic chip devices, 46 or nanocomposites based on molybdenum disulfide, 47 with detection times spanning between 80 minutes to 4 hours.…”
Section: Resultsmentioning
confidence: 99%
“…Similar design with the X biosensors enabled differentiation of single-base mutations with just a background-level signal triggered by a mismatched target, 29 a performance that cannot be achieved even by the most recent developments in the thermodynamics-based approaches. 44…”
DNA nanotechnology deals with the design of non-naturally occurring DNA nanostructures that can be used in biotechnology, medicine, and diagnostics. In this study, we introduced a nucleic acid five-way junction...
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