Thermodynamically-consistent constitutive modeling of aligned Silk fibroin sponges: Theory and application to uniaxial compression

Panda, Debojyoti; Konar, Subhajit; Bajpai, Saumendra; Arockiarajan, A.

doi:10.1016/j.ijsolstr.2018.01.006

Cited by 4 publications

(5 citation statements)

References 38 publications

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“…The interpretation, however, does not translate into mechanical effects. Recently two approaches to explain proteinbased materials mechanics from its structural organization and thermodynamics have been put forward (Puglisi et al, 2017) and (Panda et al, 2018). Still the roles of the silk secondary structures, their organization and the strong fluid coupling to the mechanics remain unclear.…”

Section: Molecular Origin Of Scaffold Morphology and Mechanical Responsementioning

confidence: 99%

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3D Structure and Mechanics of Silk Sponge Scaffolds Is Governed by Larger Pore Sizes

et al. 2020

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Three-dimensional scaffolds play an essential role in tissue engineering. Although essential, the tunability of the 3D scaffolds mechanical and transport properties remains a challenge. In this work, we present new approaches to advance the field. First, we applied our progressive pH acidification to mimic the natural silk gelation process before ice-templating (−20 and −80 • C); second, we fitted the mechanical properties using a connectivity model; third, we fitted the scaffolds mechanical relaxation to understand the transport properties; and fourth we used micro-CT to correlate the process parameters to the scaffolds' performances. Our results suggested that the free shrinkage of the scaffolds determined their final properties. We found, however, that the porosity (above 90%) was anisotropic, similarly the tortuosity (between 1 and 1.3). We identified two major pore dimensions, the first one between 10 and 20 µm, and the second between 50 and 130 µm. Mechanically, our model suggested that the bulk modulus captured the elastic contribution and was controlled predominantly by the silk concentration. We tentatively associated the fractional modulus 1 to the collapse of the larger pores structures and was controlled mostly by the process temperature. We assigned the slow relaxation to the transport of fluid in the silk sponge scaffolds; and the fast relaxation with a viscoelastic relaxation. The silk concentration and process temperatures did not influence the latter. Overall, our use of the tomography, mechanical test, and detailed statistical analysis provides inroads into the interplay between process parameters (silk concentration and process temperature) and the multiple responses of the silk sponge scaffolds. The development of a new mechanical fitting for the compression test helped capture simply the different failure modes in the sponge scaffolds as well as correlating those events to relaxation and eventually transport properties.

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Section: Molecular Origin Of Scaffold Morphology and Mechanical Responsementioning

confidence: 99%

“…In 2017, Panda et al obtained RSF sponges with oriented porous channels using a freeze-casting method (Panda et al, 2017). The mechanical properties (experimental and predicted) did not, however, correlate with the microstructure of the sponges (Panda et al, 2018). Kolahreez and Morshed concluded similarly (Kolahreez and Morshed, 2018).…”

Section: Introductionmentioning

confidence: 99%

3D Structure and Mechanics of Silk Sponge Scaffolds Is Governed by Larger Pore Sizes

et al. 2020

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“…2 (left). This is because the sponges behave somewhat like a hyperelastic material, with appropriate stored strain energy function derived in (Panda et al 2018).…”

Section: Resultsmentioning

confidence: 99%

“…Visco-hyperelastic modelling of soft materials has also been addressed to corroborate their nonlinear elasticity (Pazos et al 2009) and rate-dependency (Karimi et al 2014). In another work, a thermodynamicallyconsistent continuum based model has been developed to predict the mechanics of silk fibroin sponges (Panda et al 2018). A finite strain thermodynamically-consistent coupled viscoelastic-viscoplastic constitutive model has been proposed to predict the mechanics of glassy polymers (Gudimetla and Doghri 2017).…”

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confidence: 99%

Mechanics of soft polymeric materials using a fractal viscoelastic model

Pramanik

Soni

Shanmuganathan

et al. 2021

Mech Time-Depend Mater

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Soft materials are known for their plethora of biomedical applications, intricate structure-property correlation and nonlinear mechanical response. Multiple length-time scale phenomena and hierarchical structure results in their nonlinearity. Phenomenological and continuum mechanical models have been developed to predict their mechanics, which have mostly been very material-specific with inability to predict the mechanics of different types of soft materials simultaneously. This shortcoming has been addressed in the present work, wherein a generic nonlinear viscoelastic model has been proposed to predict the mechanical response of hydrogels, sponges, and xerogels. A fractal derivative viscoelastic model is proposed considering a fractal Maxwell model in parallel with a nonlinear spring. In particular, this model is chosen to qualitatively mimic the material nonlinearity inherent in soft materials. The fractal dashpot in combination with the nonlinear spring accounts for the power law time-dependent rheology of generic soft materials. These two different aspects in the form of nonlinear stiffness and non-Newtonian rheology account for mechanics of most soft materials. The present model is shown to fit well the existing literature results for mechanical response of a multitude of soft material classes with different test conditions and loading rates, which is one of the salient features of the model, apart from its simplistic mathematical framework. Further, a parametric study is reported on the mechanics of nanocellulose loaded poly(vinyl alcohol) xerogel. The model predictions are observed to be in conjunction with the experimental observations.

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“…Currently, there are various processing forms for SF: scaffolds, sponges, or films, etc. [ 35 , 36 , 37 , 38 , 39 , 40 ]. It has been shown that the biocompatibility feature is influenced by the purification method and the purification process.…”

Section: Sf Key Propertiesmentioning

confidence: 99%

The Contribution of Silk Fibroin in Biomedical Engineering

Lujerdean

Baci

Cucu

et al. 2022

Insects

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Silk fibroin (SF) is a natural protein (biopolymer) extracted from the cocoons of Bombyx mori L. (silkworm). It has many properties of interest in the field of biotechnology, the most important being biodegradability, biocompatibility and robust mechanical strength with high tensile strength. SF is usually dissolved in water-based solvents and can be easily reconstructed into a variety of material formats, including films, mats, hydrogels, and sponges, by various fabrication techniques (spin coating, electrospinning, freeze-drying, and physical or chemical crosslinking). Furthermore, SF is a feasible material used in many biomedical applications, including tissue engineering (3D scaffolds, wounds dressing), cancer therapy (mimicking the tumor microenvironment), controlled drug delivery (SF-based complexes), and bone, eye and skin regeneration. In this review, we describe the structure, composition, general properties, and structure–properties relationship of SF. In addition, the main methods used for ecological extraction and processing of SF that make it a green material are discussed. Lastly, technological advances in the use of SF-based materials are addressed, especially in healthcare applications such as tissue engineering and cancer therapeutics.

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Thermodynamically-consistent constitutive modeling of aligned Silk fibroin sponges: Theory and application to uniaxial compression

Cited by 4 publications

References 38 publications

3D Structure and Mechanics of Silk Sponge Scaffolds Is Governed by Larger Pore Sizes

3D Structure and Mechanics of Silk Sponge Scaffolds Is Governed by Larger Pore Sizes

Mechanics of soft polymeric materials using a fractal viscoelastic model

The Contribution of Silk Fibroin in Biomedical Engineering

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