Thermodynamic study of triacetin or ethyl levulinate and alcohol binary mixtures

Majstorović, Divna M.; Petrović, Petar I.; Kijevčanin, Mirjana Lj.; Živković, Emila M.

doi:10.1016/j.jct.2023.107004

Cited by 8 publications

(6 citation statements)

References 54 publications

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“…The densities of Dox-loaded formulations (N1 or D1) were higher than those of pure solvent (NMP or DMSO) or borneol-based ISGs because of the low density of borneol (1.01 g/cm 3 ) [18]. Based on the NMP series, the density of ISG gradually decreased with the proportion of triacetin, as shown for the N3 to N8 formulations, because of the hydrophobic and oily liquid properties of triacetin [32]. Notably, the density of N4 and N8 was significantly higher (p < 0.05) than that of N2.…”

Section: Appearance Density Viscosity and Surface Tensionmentioning

confidence: 88%

“…Hydrophobic solvents such as triacetin are recognized to produce a slow-forming phase inversion because of the limited water solubility (around 7%) [29]. Triacetin has a low water affinity [33], and the ISG solution containing triacetin was more viscous [32], which diminished the solvent exchange rate and reduced the borneol phase inversion [59]. Consequently, more water was required to induce borneol gel formation, signifying a low susceptibility to water induction.…”

Section: Water-induced Gel Formation Sensitivitymentioning

confidence: 99%

“…Triacetin (C 9 H 14 O 6 , molecular weight = 218.2) is a nontoxic edible fatty acid that can be used as an additive solvent to retard drug release [31,32]. Triacetin is moderately soluble in water (around 7%) but it is soluble in relatively hydrophobic organic solvents (log K o/w = 0.25) [31,33].…”

Section: Introductionmentioning

confidence: 99%

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Phase Inversion-Based Doxycycline Hyclate-Incorporated Borneol In Situ Gel for Periodontitis Treatment

Lertsuphotvanit

Tuntarawongsa

Chantadee

et al. 2023

Gels

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Borneol has been successfully employed as a gelling agent for in situ forming gel (ISG). While 40% borneol can regulate drug release, there is interest in novel approaches to achieve extended drug release, particularly through the incorporation of hydrophobic substances. Herein, triacetin was selected as a hydrophobic additive solvent for doxycycline hyclate (Dox)-loaded 40% borneol-based ISGs in N-methyl-2-pyrrolidone (NMP) or dimethyl sulfoxide (DMSO), which were subsequently evaluated in terms of their physicochemical properties, gel formation morphology, water sensitivity, drug release, and antimicrobial activities. ISG density and viscosity gradually decreased with the triacetin proportion to a viscosity of <12 cPs and slightly influenced the surface tension (33.14–44.33 mN/m). The low expelled force values (1.59–2.39 N) indicated the convenience of injection. All of the prepared ISGs exhibited favorable wettability and plastic deformation. Higher gel firmness from ISG prepared using NMP as a solvent contributed to the ability of more efficient controlled drug release. High triacetin (25%)-loaded ISG retarded solvent diffusion and gel formation, but diminished gel firmness and water sensitivity. ISG containing 5% triacetin efficiently prolonged Dox release up to 10 days with Fickian diffusion and presented effective antimicrobial activities against periodontitis pathogens such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. Therefore, the Dox-loaded 40% borneol-based ISG with 5% triacetin is a potential effective local ISG for periodontitis treatment.

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Section: Appearance Density Viscosity and Surface Tensionmentioning

confidence: 88%

Section: Water-induced Gel Formation Sensitivitymentioning

confidence: 99%

See 1 more Smart Citation

Phase Inversion-Based Doxycycline Hyclate-Incorporated Borneol In Situ Gel for Periodontitis Treatment

Lertsuphotvanit

Tuntarawongsa

Chantadee

et al. 2023

Gels

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“…[141] An oscillating U-tube is filled with the biodiesel sample, and its frequency of oscillation is measured. [142] Because biodiesel density varies greatly with temperature, it's crucial to take the reading under conditions that accurately reflect its final use. Overall, measuring the density of a biodiesel sample is an important part of the quality control process, since it ensures that the fuel will perform as expected.…”

Section: Densitymentioning

confidence: 99%

“…Next, we use the sample mass and volume to determine the biodiesel density [141] . An oscillating U‐tube is filled with the biodiesel sample, and its frequency of oscillation is measured [142] . Because biodiesel density varies greatly with temperature, it's crucial to take the reading under conditions that accurately reflect its final use.…”

Section: Physical Characterization Of Biodieselmentioning

confidence: 99%

A Review on Biodiesel Production, Analysis, and Emission Characteristics from Non‐Edible Feedstocks

Jamil

2023

ChemistrySelect

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Biodiesel produced from different edible and non‐edible feedstocks is a viable alternative option for fueling a combustion engine. However, the widespread use of edible sources for biodiesel production may lead to food versus fuel controversy. Oil from non‐edible feedstock is best possible solution for problems that inhibits biodiesel production on commercial scale. This study presents the potential of different non‐edible feedstock for biodiesel production. Several aspects such as extraction technologies used for extracting oil from non‐edible sources and biodiesel production pathways from non‐edible feedstocks are discussed. The quality of biodiesel should be assured before its commercialization by different physical and chemical characterization techniques are used. In particular, the emission comparison of biodiesel derived from the different non‐edible feedstocks is discussed. Based on this study, the non‐edible feedstocks have the potential to produce biodiesel but still it has a long way to go. This is due to non‐edible feedstock is in the R&D phase and needs more research to eliminate additional treatment steps compared to edible feedstock for economic aspects. Furthermore, there has been a trade off in emission properties of biodiesels produced from non‐edible feedstocks which must be removed or evaluated for pilot scale investigations before commercialization.

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Thermophysical properties of ethyl levulinate and n-alkanol systems

Abidi,

García-Gracia,

Hernández

et al. 2024

J Therm Anal Calorim

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Some thermophysical properties such as densities, speeds of sound, refractive indices, and heat flows of the binary systems ethyl levulinate and n-alkanols (methanol, ethanol, 1-propanol, and 1-butanol) are reported in the temperature range T = (283.15–313.15) K and at p = 100 kPa. From these experimental data, the excess properties were calculated and correlated with the composition using a modified Redlich–Kister equation. The excess molar volumes were negative for short-chain alcohols and positive for 1-propanol and 1-butanol. The excess refractive indices exhibited the opposite behaviour. The excess isentropic compressibilities were negative and the excess molar enthalpies, were positive. The perturbed chain statistical associating fluid theory equation of state (PC-SAFT EoS) was successfully applied to correlate the densities of the mixtures, and good qualitative results in the computation of the excess molar enthalpy were obtained. Furthermore, Schaaff’s collision factor theory (SCFT) and the Laplace mixing rule were coupled with PC-SAFT to predict the speed of sound and the refractive index, respectively.

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Thermodynamic study of triacetin or ethyl levulinate and alcohol binary mixtures

Cited by 8 publications

References 54 publications

Phase Inversion-Based Doxycycline Hyclate-Incorporated Borneol In Situ Gel for Periodontitis Treatment

Phase Inversion-Based Doxycycline Hyclate-Incorporated Borneol In Situ Gel for Periodontitis Treatment

A Review on Biodiesel Production, Analysis, and Emission Characteristics from Non‐Edible Feedstocks

Thermophysical properties of ethyl levulinate and n-alkanol systems

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