Thermodynamic Studies on Amino Acid Solvation in some Aqueous Alcohols

Das, Pravakar; Chatterjee, Supriya; Basumallick, Indra N.

doi:10.1002/jccs.200400001

Cited by 30 publications

(11 citation statements)

References 14 publications

(14 reference statements)

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“…The molal solubilities in the aqueous-electrolyte as well as in pure water were used to determine apparent standard Gibbs energy of solutions (ΔGs0true(itrue)) on molal scale using Eq. (2) [33, 34, 35, 36]. …”

Section: Resultsmentioning

confidence: 99%

Solubility analysis of homologous series of amino acids and solvation energetics in aqueous potassium sulfate solution

Hossain

Mahali

Dolui

et al. 2019

Heliyon

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In this study we estimated the solubilities of glycine, D,L-alanine, D,L-nor-valine and D,L-serine in aqueous mixtures of potassium sulfate (K 2 SO 4 ) at 298.15 K using analytical ‘gravimetric method’. The experimental solubilities of homologous series of amino acids in aqueous K 2 SO 4 mixture were discussed in terms of relative solubility, salting-in and salting-out effect by evaluating the influential constants. The effect of physicochemical and chemical factors on solubility were discussed briefly and correlated with the thermodynamics. Initially, the study of solvation energetics such as transfer Gibbs energies were evaluated based on the calculations from solubility data and relative stability of the experimental molecules was discussed under the experimental condition.

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Section: Resultsmentioning

confidence: 99%

Solubility analysis of homologous series of amino acids and solvation energetics in aqueous potassium sulfate solution

Hossain

Mahali

Dolui

et al. 2019

Heliyon

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show abstract

“…Like previous studies, 21,[27][28][29][30][31][32]36,43,44,46 the standard Gibbs energies of solutions (ΔG s 0 ) on molal scale at a particular temperature can be calculated in the present study by using eq 1,…”

Section: Theoretical Sectionmentioning

confidence: 99%

“…In considering these points of views and to explore the solvation mechanisms of various amino acids, the solubility and thermodynamic studies were also carried out by different group of researchers in different aquo-organic − and nonaqueous solvent systems. − The results in terms of solvation thermodynamics reflected that difference in proticity, dipolar aproticity, acid–base property, hydrophilicity, hydrophobicity, and chemical nature of reference and cosolvents of such binary solvent systems − influence the relative stability as well as solvation mechanism of amino acids.…”

Section: Introductionmentioning

confidence: 99%

Solubility and Chemical Thermodynamics of d,l-Alanine and d,l-Serine in Aqueous NaCl and KCl Solutions

2015

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The solubilities of D,L-alanine and D,L-serine in aqueous sodium chloride (NaCl) and potassium chloride (KCl) solutions are determined at five equidistant temperatures by using "formol titrimetry". The thermodynamic parameters such as standard transfer Gibbs energies, entropies, and enthalpies have been evaluated at 298.15 K. Other important related parameters like molar mass, density, molar volume, dipole moment, and solvent diameter, etc., of the experimental solutions are also determined in the present study. ΔG t,ch 0 (i), i.e., chemical effects of the transfer Gibbs energies, and TΔS t,ch 0 (i), i.e., chemical effects of the transfer entropy of these amino acids, are also evaluated and discussed, the factors which are dependent on mainly nature of the solute, solvent, interactions between solute and solvent, etc. The nature and the extent of the involved factors, which are influencing the solvation of the amino acids in aqueous NaCl and KCl solutions, are also explained by the different physical and analytical approaches.

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“…The conformation of a protein in solution is generally a function of electrostatic forces, hydrogen bonding, van der Walls forces, acid-base interactions, and hydrophobic and hydrophilic interactions among the amino acid residues that overall lead to a folded state overcoming an entropic penalty [1][2][3]. Denaturation or defolding of a protein is also an essential process for dissolution and purification of proteins during their extraction from natural sources.…”

Section: Introductionmentioning

confidence: 99%

Chemical Transfer Energetics of a Series of Homologous α-Amino Acids in Quasi-Aprotic 2-Methoxyethanol–Water Mixtures

2016

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The zwitterionic solvation behavior of a series of the homologous a-amino acids glycine (Gly), DL-alanine (Ala), DL-a-amino butyric acids (Aba) and DL-nor-valine (Val), in water and in aqueous mixtures of 2-methoxyethanol, have been studied at equidistant temperature intervals in the range of 288.15-308.15 K, using the solubility method. The solubility data were analyzed according to the 'formol titrimetric' process. Standard Gibbs energies DG 0 t ðiÞ and entropies DS 0 t ðiÞ of transfer were calculated and are discussed. The observed DG 0 t ðiÞ and TDS 0 t ðiÞ versus composition profiles are complicated because of the various interaction effects. The chemical effects of the transfer Gibbs energies DG 0 t;ch ðiÞ and entropies of transfer TDS 0 t;ch ðiÞ have been obtained after elimination of the cavity effect, estimated by the scaled particle theory and dipole-dipole interaction effects, calculated by use of the Keesom orientation expression. The chemical contributions to transfer energetics of homologous a-amino acids are guided by the combined effects of increased dispersion interaction, basicity and decreased acidity, hydrogen bonding effects and hydrophilic hydration of aqueous 2-methoxy ethanol as compared to that of reference solvent, water. In this context the solvating characters of protic ethylene glycol are also referred to for comparison.

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Thermodynamic Studies on Amino Acid Solvation in some Aqueous Alcohols

Cited by 30 publications

References 14 publications

Solubility analysis of homologous series of amino acids and solvation energetics in aqueous potassium sulfate solution

Solubility analysis of homologous series of amino acids and solvation energetics in aqueous potassium sulfate solution

Solubility and Chemical Thermodynamics of d,l-Alanine and d,l-Serine in Aqueous NaCl and KCl Solutions

Chemical Transfer Energetics of a Series of Homologous α-Amino Acids in Quasi-Aprotic 2-Methoxyethanol–Water Mixtures

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