Thermodynamic Studies of Aqueous m–s–m Gemini Surfactant Systems

In vivo cutaneous interferon‐γ gene delivery using novel dicationic (gemini) surfactant–plasmid complexes

“…A larger Gibbs area (a) per molecule (lower surface excess concentration, , at the air/water interface) [30] correlated with a lower transfection efficiency (Table 1). These parameters reflect the importance of the spacer length in binding of the gemini surfactant to DNA.…”

“…Eight gemini surfactants were tested in this study ( Figure 1A) [30]. Aqueous solutions (1.5 mM) of the gemini cationic surfactants were prepared and filtered through 0.2 µm Acrodisc  filters (Pall Gelman, Ann Arbor, MI, USA).…”

Structural and transfection properties of amine‐substituted gemini surfactant‐based nanoparticles

“…The synthesis of the surfactants used in this study has been previously described [24,25]. Aqueous solutions (1.5 mM) of the gemini surfactants were prepared and filtered through 0.2 µm Acrodisc  filters (Pall Gelman, Ann Arbor, MI, USA).…”

Studies of the Interaction of Cationic Gemini Surfactants with Polymers and Triblock Copolymers in Aqueous Solution

“…Properties and characteristics of N,Nbis(dimethyldodecyl)-α,ω-alkanediammonium dibromide gemini surfactants, of the m-s-m type, where m is the length of the n-alkyl tail and s is the length of the polymethylene spacer, have been extensively reported in the literature, from both experimental (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) and theoretical (20,21) perspectives. The choice of gemini surfactants was made to explore the effect of varying the size of the head group of these compounds on the interactions with neutral polymers in solution.…”