“…Phase transitions including polymorph interconversion, hydrate formation, and solvate desolvation − may happen under different processes, such as crystallization, granulation, compaction, drying, storage, and transport. It will further affect the performance (stability, − particle size and shape, − flowability, hygroscopicity, − and solubility − ) of the active pharmaceutical ingredients . Consequently, a thorough characterization of all possible pharmaceutical polymorphs and investigation of the phase transformation process are crucial for selecting the optimal solid form for development. − Furthermore, mapping the solid form landscapes will increase the understanding of the physicochemical properties and crystallization behavior of crystal forms, which can contribute to product design and process development.…”