Thermodynamic solubility of pioglitazone HCl in polyethylene glycols 200, 400 or 600+water mixtures at 303.2 and 308.2K—Data report and modeling

Soltanpour, Shahla; Zohrabi, Fatemeh; Bastami, Zahra

doi:10.1016/j.fluid.2014.07.024

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…The Jouyban–Acree model is widely used to represent both temperature and composition of mixed solvents effects on solubility of solute . The general form of the equation could be written as In formula , J i terms are the Jouyban–Acree model parameter and T is the absolute temperature; ω 2 and ω 3 represent the mass fractions of isopropanol and ethyl acetate of the solution, respectively, ω 3 = 1 – ω 2 ; ( x 1 ) 2 , and ( x 1 ) 3 are the mole fraction solubility of 2,4-dimethoxybenzoic acid in the isopropanol and ethyl acetate respectively.…”

Section: Resultsmentioning

confidence: 99%

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Determination and Modeling of the Solubility of 2,4-Dimethoxybenzoic Acid in Six Pure and Isopropanol + Ethyl Acetate Mixed Organic Solvents at Temperatures From (288.15 to 323.15) K

Tian

Wu³

et al. 2015

J. Chem. Eng. Data

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In our experiment, a dynamic method was taken to measure the solubilities of the 2,4-dimethoxybenzoic acid under atmospheric pressure (p = 0.1 MPa) in ethanol, npropanol, isopropanol, n-butanol, isobutanol, and ethyl acetate as well as in the isopropanol + ethyl acetate mixtures from (288.15 to 323.15) K. The experiment results have proved that the rising temperature leads to increased solubility of the 2,4-dimethoxybenzoic acid in all selected solvents. The changing model parameters in each selected solvent was recorded and calculated, respectively, during the experiments and the solid− liquid equilibrium data in pure and mixed solvents was correlated with a series equations, including the modified Apelblat equation, Wilson equation, UNIQUAC equation, and the Jouyban−Acree. During the study, the computational values were in good agreement with the experimental results according to the calculations based on all selected equations, however the modified Apelblat equation stood out to be the most suitable with the most accuracy. In addition, some thermodynamic parameters of the solution of 2,4-dimethoxybenzoic acid including dissolution enthalpy (ΔH sol ), entropy (ΔS sol ) and the Gibbs energy (ΔG sol ) were obtained via the van't Hoff analysis. The positive values ofΔH sol andΔG sol indicated that the dissolution process of dissolving 2,4-dimethoxybenzoic acid is endothermic.

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Section: Resultsmentioning

confidence: 99%

“…The Jouyban−Acree model is widely used to represent both temperature and composition of mixed solvents effects on solubility of solute. 19 The general form of the equation could be written as 20…”

Section: ■ Introductionmentioning

confidence: 99%

Determination and Modeling of the Solubility of 2,4-Dimethoxybenzoic Acid in Six Pure and Isopropanol + Ethyl Acetate Mixed Organic Solvents at Temperatures From (288.15 to 323.15) K

Tian

Wu³

et al. 2015

J. Chem. Eng. Data

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“…Several studies proved the potential use of PEG 400 in enhancing the solubility of various poorly water-soluble drugs such as meloxicam, acetaminophen, indomethacin, tadalafil, isatin, and silymarin . Similar studies also showed the solubility behavior of hydrophobic drugs such as acetaminophen, ibuprofen, pioglitazone hydrochloride, lamotrigine, clonazepam, and diazepam in aqueous and nonaqueous PEG 600 systems. − PG is a colorless, odorless, viscous organic liquid and it has been used almost exclusively in the production of water insoluble drugs . Moreover, it can be used as solvent and diluent in pharmaceutical preparations.…”

Section: Introductionmentioning

confidence: 97%

Solubility of Etoricoxib in Aqueous Solutions of Glycerin, Methanol, Polyethylene Glycols 200, 400, 600, and Propylene Glycol at 298.2 K

Rathi¹,

Kale

Soleymani

et al. 2018

J. Chem. Eng. Data

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Experimental molar solubility of etoricoxib (ETR) in monosolvents such as glycerin, methanol (MeOH), polyethylene glycol 200 (PEG 200), polyethylene glycol 400 (PEG 400), polyethylene glycol 600 (PEG 600), propylene glycol (PG), and their aqueous binary solvent systems in various mass fraction compositions along with the solute-free and saturated solution densities were measured at 298.2 K. The resulting mole fraction solubility and density data were further correlated and predicted with the Jouyban−Acree model. Overall mean percentage deviations (OMPDs) between experimental and calculated mole fraction solubilities were 3.5%. The solute-free density of the monosolvents and their aqueous binary solvent systems were employed to train the model and then the densities of the saturated solutions were predicted. Moreover, OMPDs for back calculated solute-free densities and predicted saturated solution densities were 0.07% and 0.40%, respectively. Thus, the Jouyban−Acree model have potential use in preformulation and formulation studies during which solubility and density calculations are important physicochemical properties for design and development of new drug products in pharmaceutical industries. The simulated data could also be employed in crystallization and other related process design in the pharmaceutical/chemical industry.

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Theoretical and Experimental Study of the Thermodynamic Solubility of Pioglitazone HCl in Ethanol, N-Methyl Pyrrolidone or Propylene Glycol + Water Mixtures at Various Temperatures

Soltanpour

Zohrabi

2016

J Solution Chem

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Thermodynamic solubility of pioglitazone HCl in polyethylene glycols 200, 400 or 600+water mixtures at 303.2 and 308.2K—Data report and modeling

Cited by 4 publications

References 7 publications

Determination and Modeling of the Solubility of 2,4-Dimethoxybenzoic Acid in Six Pure and Isopropanol + Ethyl Acetate Mixed Organic Solvents at Temperatures From (288.15 to 323.15) K

Determination and Modeling of the Solubility of 2,4-Dimethoxybenzoic Acid in Six Pure and Isopropanol + Ethyl Acetate Mixed Organic Solvents at Temperatures From (288.15 to 323.15) K

Solubility of Etoricoxib in Aqueous Solutions of Glycerin, Methanol, Polyethylene Glycols 200, 400, 600, and Propylene Glycol at 298.2 K

Theoretical and Experimental Study of the Thermodynamic Solubility of Pioglitazone HCl in Ethanol, N-Methyl Pyrrolidone or Propylene Glycol + Water Mixtures at Various Temperatures

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